Results 101 to 110 of about 52,598 (267)

Impact of Accelerated Antimicrobial Testing on Clinical Outcomes in Critically Ill Septicaemia Patients: A Prospective Observational Study form a Tertiary Care Centre in Andhra Pradesh, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Bloodstream infection is a major cause of mortality and morbidity worldwide. Timely reporting of blood culture results is of utmost importance for better patient outcomes.
Renuka Devi Avula, Haritha Jakkula, Chakrapani Kammineni   +2 more
doaj   +1 more source

How to: EUCAST recommendations on the screening procedure E.Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates

, 2019
BACKGROUND: The emergence of azole-resistant Aspergillus fumigatus isolates is a matter of significant concern in Europe, with countries reporting resistance rates (which can be as high as 30%) in hospitalized patients.
Guinea, J, Verweij, PE, Subcommittee, on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), Arendrup, MC, Meletiadis, J, Mouton, JW, Barchiesi, F   +6 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Developmental roadmap for antimicrobial susceptibility testing systems [PDF]

, 2018
Antimicrobial susceptibility testing (AST) technologies help to accelerate the initiation of targeted antimicrobial therapy for patients with infections and could potentially extend the lifespan of current narrow-spectrum antimicrobials.
Becker, K, Mitsakakis, K, Peter, H, Lisby, Gorm, Belkum, A, Moran-Gilad, J, Hays, John; id_orcid, Bachmann, Till T., Vila, J. (Jordi), Vila Estapé, Jordi, Dunne Jr, Wm. Michael, Mohess, Allan, Kahlmeter, G., Dunne, W.M. (William Michael), Woodford, Neil, Woodford, N, Hays, J.P. (John), Peter, H. (Harald), Harald Peter, Wm. Michael Dunne, Mohess, A, Bachmann, T.T. (Till T.), Mitsakakis, K. (Konstantinos), Becker, K. (Karsten), Kahlmeter, Gunnar, John P. Hays, Hays, John, Konstantinos Mitsakakis, Jordi Vila, Jacob Moran-Gilad, Dunne, WM, Ludke, Gerd, Till T. Bachmann, Luz, Saturnino; id_orcid, Lüdke, Gerd H., Rex, J.H. (John H.), Gerd Lüdke, Bachmann, TT, Becker, Karsten, Mitsakakis, Konstantinos, Moran-Gilad, Jacob, Dunne Jr., Wm. Michael, van Belkum, Alex, Lüdke, G. (Gerd), John H. Rex, Peter, Harald, Neil Woodford, Gunnar Kahlmeter, Woodford, N. (Neil), Lisby, Jan Gorm, Hays, John P., Allan Mohess, Vila, J, Belkum, A.F. (Alex) van, Vila, Jordi, Peter, Harold, Lisby, JG, Rex, JH, Bachmann, Till, Mohess, A. (Allan), Karsten Becker, Ludke, G, Kahlmeter, G, Rex, John H., Jan Gorm Lisby, Moran-Gilad, J. (Jacob), Lisby, J.G. (Jan Gorm), Alex van Belkum   +67 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Smartphone-based polydiacetylene colorimetric sensor for point-of-care diagnosis of bacterial infections

Smart Materials in Medicine
The rapid progress in point-of-care testing (POCT) has become a promising decentralized patient-centered approach for the control of infectious diseases, especially in resource-limited settings. POCT devices should be inexpensive, rapid, simple operation
Yue Zhou, Yumeng Xue, Xubo Lin, Menglong Duan, Weili Hong, Lina Geng, Jin Zhou, Yubo Fan   +7 more
doaj   +1 more source

Bacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus [PDF]

, 2016
Successful treatment of bacterial infections requires the timely administration of appropriate antimicrobial therapy. The failure to initiate the correct therapy in a timely fashion results in poor clinical outcomes, longer hospital stays, and higher ...
G. Sakoulas, Pogliano, K., K. Pogliano, Pogliano, J., Nizet, V., Nizet, V, J. Pogliano, Quach, DT, Sakoulas, G., D.T. Quach, Pogliano, J, Quach, D.T., Pogliano, K, V. Nizet, Sakoulas, G   +14 more
core   +1 more source