Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling [PDF]
, 2014 The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD).
Akishita +123 more
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OncoImmunology, 2018 To identify novel hubs for cancer immunotherapy, we generated C57BL/6J mice with concomitant deletion of the drugable transcription factor PPARγ and transgenic overexpression of the mutant KRASG12V oncogene in enterocytes.
Tobias Gutting +12 more
doaj +1 more source
Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]
, 2018 We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T +10 more
core +3 more sources
Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2 [PDF]
Molecular and Cellular Biology, 2001 Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2. GRF2 is a widely expressed protein with several recognizable sequence motifs, including a Ras exchanger motif (REM), a PEST region containing a destruction box (DB), and a Cdc25 domain.
C L, de Hoog +5 more
openaire +2 more sources
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab [PDF]
, 2015 Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone.
Abouelkhair, KM +10 more
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Effect of addition of mineral salts to recirculating aquaculture system: evaluation of water quality, growth performance and some biochemical and immune indices of African cichlid (Labidochromis lividus) fish [PDF]
بومشناسی آبزیان, 2022 In the present study, the effects of startup and addition of ammonium chloride (NH4Cl) and sodium nitrite (NaNO2) salts for 4 weeks before fish stocking on efficiency of biofilter for removal of total ammonia nitrogen (TAN) from water, survival rate ...
Mehrdad Sarkheil +2 more
doaj
RAS and beyond: the many faces of the neurofibromatosis type 1 protein
Disease Models & Mechanisms, 2022 Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for benign and malignant tumor formation caused by germline mutations in the NF1 gene.
Corina Anastasaki +2 more
doaj +1 more source
Importance and applications of robotic and autonomous systems (RAS) in railway maintenance sector: a review [PDF]
, 2019 Maintenance, which is critical for safe, reliable, quality, and cost-effective service, plays a dominant role in the railway industry. Therefore, this paper examines the importance and applications of Robotic and Autonomous Systems (RAS) in railway ...
Ackerman +6 more
core +3 more sources
Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture [PDF]
, 1999 Due to their mode of action, ribozymes show antisense effects in addition to their specific cleavage activity. In the present study we investigated whether a hammerhead ribozyme is capable of cleaving mutated Ki-ras mRNA in a pancreatic carcinoma cell ...
Giannini, Claudio Detlef +3 more
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Dynamic regulation of RAS and RAS signaling
Biochemical Journal, 2023 RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact with a wide range of effectors that control fundamental biochemical and biological processes. Emerging
Walter Kolch, Dénes Berta, Edina Rosta
openaire +3 more sources