Results 261 to 270 of about 380,814 (333)

RAS Mutation-Specific Responses to Paralog- and State-Selective RAS Inhibitors. [PDF]

Mol Cancer Res
Baars B, Orive-Ramos A, Emmett MJ, Gaire B, Desaunay M, Kou Z, Li G, Adamopoulos C, Aaronson SA, Wang S, Sellers WR, Martin T, Gavathiotis E, Poulikakos PI.   +13 more
europepmc   +1 more source

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma. [PDF]

Nat Commun
Zhou Y, Wang Y, Shi X, Wang J, Zang Z, Zhang L, Gui Z, Cai X, Hu P, Wang J, Liu H, Wang Z, Guan H, Wu X, Shen C, He Y, Li M, Zhang H, Wang J, Wu Y, Chen C, Zhu Y, Sun Y, Liu Z, Wang Y, Guo T.   +25 more
europepmc   +1 more source

Probing the Hotspot Binding Sites of Proteins: P22TSP, Ras and BAF

, 2013
Mychal Daijon Smith
openalex   +1 more source

Ras-dependent Activation of c-Jun N-terminal Kinase/Stress-activated Protein Kinase in Response to Interleukin-3 Stimulation in Hematopoietic BaF3 Cells

, 1997
Koji Terada, Yoshito Kaziro, Takaya Satoh   +2 more
openalex   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

K-RAS Protein Vaccine [PDF]

, 2020
openaire   +1 more source

Development of a Genetically Encoded and Potent PDE6D Inhibitor. [PDF]

Chembiochem
Gómez-Mulas A, Schaffner-Reckinger E, Peeters H, Chippalkatti R, Dautbasic A, Smith MJ, Ismail S, Abankwa DK.   +7 more
europepmc   +1 more source

Bisphenol A Binds to Ras Proteins and Competes with Guanine Nucleotide Exchange: Implications for GTPase-Selective Antagonists

, 2013
Miriam Schöpel, Katharina F. G. Jockers, Peter M. Düppe, Jasmin Autzen, Veena Nambiar Potheraveedu, Semra İnce, King Tuo Yip, Rolf Heumann, Christian Herrmann, Jürgen Scherkenbeck, Raphael Stoll   +10 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source