Results 111 to 120 of about 3,325,271 (304)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Note on Iterations of Nonlinear Rational Functions

Axioms
This paper investigates a class of nonlinear rational difference equations with delayed terms, which often arise in various mathematical models.
Michal Fečkan, Amira Khelifa, Yacine Halim, Ibraheem M. Alsulami   +3 more
doaj   +1 more source

Computation of Zolotarev Rational Functions

SIAM Journal on Scientific Computing
An algorithm is presented to compute Zolotarev rational functions, that is, rational functions $r_n^*$ of a given degree that are as small as possible on one set $E\subseteq\complex\cup\{\infty\}$ relative to their size on another set $F\subseteq\complex\cup\{\infty\}$ (the third Zolotarev problem).
Lloyd N. Trefethen, Heather D. Wilber
openaire   +4 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Rational Krylov sequences and orthogonal rational functions [PDF]

, 2007
In this paper we study the relationship between spectral decomposition, orthogonal rational functions and the rational Lanczos algorithm, based on a simple identity for rational Krylov sequences.status ...
Bultheel, Adhemar, Deckers, Karl
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Error estimation in the numerical solution of rational functions

Journal of Applied Sciences and Environmental Management, 2005
In this paper, two methods are described for obtaining estimates of the error of rational functions the Pade\'s and Meahly\'s methods of approximation were used and it was discovered that Maehly\'s proved more accurate than the Pade\'s method.
FO Akinpelu, AA Adetunde, EO Omidiora
doaj   +1 more source

On invariant rational functions under rational transformations

Selecta Mathematica
Let $X$ be an algebraic variety equipped with a dominant rational self-map $ϕ:X\to X$. A new quantity measuring the interaction of $(X,ϕ)$ with trivial dynamical systems is introduced; the stabilised algebraic dimension of $(X,ϕ)$ captures the maximum number of new algebraically independent invariant rational functions on the cartesian product of $(X ...
Bell, Jason, Moosa, Rahim, Satriano, Matthew   +2 more
openaire   +3 more sources