Results 51 to 60 of about 97,044 (222)

Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]

PLoS ONE, 2013
Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Genetical genomic determinants of alcohol consumption in rats and humans

BMC Biology, 2009
Background We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH recombinant inbred rat strains.
Mangion Jonathan, Pravenec Michal, Hübner Norbert, Heinig Matthias, Bell Richard L, Kechris Katerina, Richardson Heather N, Koob George, Goldman David, Hodgkinson Colin, Flodman Pam, Printz Morton, Saba Laura, Tabakoff Boris, Legault Lucie, Dongier Maurice, Conigrave Katherine M, Whitfield John B, Saunders John, Grant Bridget, Hoffman Paula L   +20 more
doaj   +1 more source

Genetic relationships between inbred strains of rats. An analysis based on genetic markers at 28 biochemical loci.

Genetical research, 1984
Genetic similarities among 46 strains of rats based on published data involving 93 samples and 28 biochemical loci were assessed using principal coordinate and cluster analysis techniques. Seventeen strains were represented by more than one colony.
M. Festing, K. Bender
semanticscholar   +1 more source

Muffled olfactory and sensory cues from the reproductive stage soybean selectively reduce oviposition of a major polyphagous herbivore, fall armyworm (Spodoptera frugiperda)

Pest Management Science, EarlyView.
Fall armyworm (FAW) preferred ovipositing on vegetative‐stage soybeans. While ‘mother knows best’ may not apply in soybean‐FAW system, muffled cues in the reproductive stage could positively influence host success. Abstract BACKGROUND While the mother knows best/preference performance hypothesis has been well tested in natural ecosystems, how these ...
Krishnarao Gandham, Manish Gautam, Justin George, Gadi V.P. Reddy, Rupesh Kariyat   +4 more
wiley   +1 more source

Transgenerational plasticity research: Challenges and opportunities

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Transgenerational plasticity (TGP) is a type of non‐genetic inheritance whereby one generation's environment affects a subsequent generation's phenotype. It can influence the persistence of organisms in stressful climatic conditions through allowing rapid phenotypic ...
Caitlin McAndry, Alastair J. Wilson, Peter A. Cotton, Manuela Truebano   +3 more
wiley   +1 more source

Fischer 344 and Lewis rat strains as a model of genetic vulnerability to drug addiction

Frontiers in Neuroscience, 2016
Today it is well acknowledged that both nature and nurture play important roles in the genesis of psychopathologies, including drug addiction. Increasing evidence suggests that genetic factors contribute for at least 40-60 % of the variation in liability
Cristina eCadoni
doaj   +1 more source

Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice

Aging Cell, EarlyView.
Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context of voluntary exercise are mitigated by intermittent dosing.
Christian J. Elliehausen, Szczepan S. Olszewski, Dennis M. Minton, Carolyn G. Shult, Aditya R. Ailiani, Michaela E. Trautman, Reji Babygirija, Dudley W. Lamming, Troy A. Hornberger, Adam R. Konopka   +9 more
wiley   +1 more source

Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats

Scientific Reports, 2017
Both social environment and genetic factors are critical for smoking initiation and nicotine addiction. We reported that rats developed conditioned flavor (i.e., taste and odor) aversion to intravenously self-administered (IVSA) nicotine, and that social
Wenyan Han, Tengfei Wang, Hao Chen
doaj   +1 more source

Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.

PLoS ONE, 2016
Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle ...
Lishi Wang, Yan Jiao, Yongjun Wang, Mengchen Zhang, Weikuan Gu   +4 more
doaj   +1 more source