Results 111 to 120 of about 798,166 (289)

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Global gene-expression profiles of intracellular survival of the BruAb2_1031 gene mutated Brucella abortus in professional phagocytes, RAW 264.7 cells

BMC Microbiology, 2018
Background Since recognizing the interaction between Brucella and host cells is crucial to the elucidation of the infectious process, Brucella researches have prioritized the investigation of genes related to pathogenicity.
Myunghwan Jung, Soojin Shim, Young Bin Im, Woo Bin Park, Han Sang Yoo   +4 more
doaj   +1 more source

siRNA-mediated Knockdown – RAW 264.7 v1

This protocol details steps taken to perform siRNA-mediated knockdowns in RAW 264.7 cells.
Amanda Bentley-DeSousa, Shawn Ferguson
openaire   +1 more source

Effects of terpenoid compounds on inflammation and its related epigenetics in lipopolysaccharide-stimulated RAW 264.7 macrophages

, 2014
萜類化合物(terpenoid compounds)是由異戊二烯單元體所組成的衍生物，普遍存在動物體及植物體中，可分類為單萜類、倍半萜類、雙萜類、三萜類及四萜類。研究指出，萜類化合物具有多種生理功能如抗發炎及抗癌，但對發炎相關的表觀遺傳仍無完整研究，因此本研究篩選具抗發炎潛力的萜類化合物，探討在發炎、預防及治療三種模式下，其對脂多醣(lipopolysaccharide, LPS)刺激RAW 264.7巨噬細胞組蛋白修飾、組蛋白修飾酵素基因表現及DNA甲基轉移酶(DNA ...
Huang, Chun-Yi, 黃淳逸
core  

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Anti-inflammatory activity and metabolite profiling of myo-inositol in LPS-stimulated macrophages.

PLoS ONE
There has been increasing interest in using dietary bioactive substances to alleviate and reduce inflammation. This study aims to assess myo-inositol's possible anti-inflammatory effects, especially in handling conditions associated with macrophage ...
Marwa Seif, Lina Dahabiyeh, Afnan Al-Hunaiti, Mohammad Semreen, Malek Zihlif, Hamzeh Al-Ameer, Amer Imraish   +6 more
doaj   +1 more source

Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line

Mediators of Inflammation, 2018
Proinflammatory responses are important aspects of the immune response to biomaterials, which may cause peri-implantitis and implant shedding. The purpose of this study was to test the cytotoxicity and proinflammatory effects of dicalcium silicate ...
Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang   +7 more
doaj   +1 more source

RAW 264.7 Cell Culture Protocol

This document provides a brief Standard Operating Procedure (SOP) for the culture of RAW 264.7 cells. It summarizes their origin and growth requirements to support students in planning experiments and maintaining good cell culture practice. The aim is to promote reproducibility, avoid common pitfalls in mammalian cell culture, and ensure responsible ...
openaire   +1 more source

Effect of morin on MSU crystal-induced mRNA expression levels in RAW 264.7 macrophage cells.

, 2016
The mRNA expression of (A) TNF-α, (B) IL-1β, (C) IL-6, (D) MCP-1, (E) iNOS, (F) COX-2, (G) NF-κBp65, (H) HPRT were measured with RT-PCR analysis. RQ values are calculated relative to the GAPDH gene.
Sowmiya Kalaiselvan (841575), Chitra Dhanasekar (841574), Mahaboobkhan Rasool (841576)   +2 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source