Results 101 to 110 of about 1,041,724 (230)
, 2013 Control (A) or LPS-activated (B) Rab6–GFP transfected RAW 264.7 macrophages were prepared for cryo-immunogold EM (see Materials and Methods) and then stained for GFP and p230. Unstimulated macrophages did not reveal Rab6 and p230 frequently associated on
Juliana Venturato (380754) +9 more
core +1 more source
Advanced Science, EarlyView.Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou +15 more
wiley +1 more source
Angewandte Chemie, EarlyView.A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho +3 more
wiley +2 more sources
Herb Mixture Inhibits Proinflammatory Mediators Through the Suppression of JNK and P38 Activation in LPS-Stimulated Raw 264.7 Macrophages [PDF]
, 2020 Inflammation has been implicated as a pathophysiological feature underlying many chronic diseases. In the present study, we investigated the anti-inflammatory effect of new formulation of herb medicine, DG1102, composed by five different herbal ...
Hee Jung Yoon +9 more
core
Advanced Science, EarlyView.Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun +12 more
wiley +1 more source
New Alkaloids and Anti-inflammatory Constituents from the Leaves of
Natural Product Communications, 2017 Using various chromatographic methods, two new alkaloids, antidesoic acids A ( 1 ) and B ( 2 ) along with fourteen known compounds ( 3 - 16 ) were isolated from the leaves of Antidesma ghaesembilla Gaertn.
Phan Van Kiem +10 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui +12 more
wiley +1 more source
Advanced Science, EarlyView.When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li +11 more
wiley +1 more source
Advanced Science, EarlyView.An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen +10 more
wiley +1 more source