Results 111 to 120 of about 1,041,724 (230)

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

LPS-induced apoptosis is partially mediated by hydrogen sulphide in RAW 264.7 murine macrophages

, 2019
Lipopolysaccharide (LPS) induces apoptosis in murine macrophages through the autocrine secretion of tumor necrosis factor (TNF)-α and nitric oxide (NO).
Ramasamy, Tamizhselvi, Kuttulebbai Naina Mohamed Salam, Sirajudeen, George, Leema, Manickam, Venkatraman   +3 more
core   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

D-allose suppresses colitis associated carcinogenesis by reversing ER stress in macrophages and inhibiting cancer cell proliferation

Frontiers in Immunology
IntroductionInflammatory bowel diseases (IBD), especially ulcerative colitis, are associated with a high risk of carcinogenesis. D-allose, a D-glucose epimer, exhibits antioxidant and antitumor activities.
Xiaodong Li, Keizo Hiraishi, Kensuke Kumamoto, Shin-ichi Nakakita, Tetsuo Yamashita, Kazuyo Kamitori, Kiyomi Ohmichi, Ryou Ishikawa, Lin Hai Kurahara   +8 more
doaj   +1 more source

pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging

Advanced NanoBiomed Research, EarlyView.
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang, Liwei Liu, Jiayuan Zhu, Xinghao Hu, Changkui Fu, Yao Wang, Lining Arnold Ju, Thomas P. Davis, Andriansjah Rukmana, Shaohua Ma, Zheng Zhang, Ruirui Qiao   +11 more
wiley   +1 more source

Metabolism of Herpes Simplex Virus 1 Infected Raw 264.7 Macrophages [PDF]

, 2016
Macrophages are immune cells that phagocytize pathogens and act as antigen presenting cells. Macrophages are critical in regulating the adaptive immune response and play a key role in neutralizing infection.
Jenkins, Mary K.
core   +1 more source

CD44-mediated cyclooxygenase-2 expression and thromboxane A2 production in RAW 264.7 macrophages.

, 2001
OBJECTIVE AND DESIGN CD44 is the major cell surface receptor for hyaluronan (HA) on macrophages. Stimulation of macrophages via the HA-CD44 pathway leads to the enhanced expression of inflammatory gene products, including cytokines, chemokines, and ...
Wahl P, Sun LK, Bilic G, Wüthrich RP
core   +1 more source

Lipoarabinomannan from Mycobacterium smegmatis Stimulates an Inflammatory Response in RAW 264.7 Murine Macrophages

, 2019
Macrophages are a key leukocyte in defense against Mycobacterium tuberculosis infection. The precise mechanism by which M. tuberculosis evades host macrophage defenses remains unknown, so understanding how macrophages interact with cell wall components ...
Zaman, Aysha
core   +1 more source

The Expression of Aryl Hydrocarbon Receptor in RAW 264.7 Macrophages in the Presence of SOCS1 Peptide and SOCS3 Peptide Mimetic and Cells Infected with HSV-1 [PDF]

, 2016
Macrophages play a crucial role for our immune system and protect our body from infection. Suppressor of cytokine signaling (SOCS) proteins negatively regulate cytokine receptor and TLRs.
Alwethaynani, Maher Salem
core   +1 more source

So Shiho Tang Reduces Inflammation in Lipopolysaccharide-Induced RAW 264.7 Macrophages and Dextran Sodium Sulfate-Induced Colitis Mice

Biomolecules
So Shiho Tang (SSHT) is a traditional herbal medicine commonly used in Asian countries. This study evaluated the anti-inflammatory effect of SSHT and the associated mechanism using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and murine ...
Mei Tong He, Geonha Park, Do Hwi Park, Minsik Choi, Sejin Ku, Seung Hyeon Go, Yun Gyo Lee, Seok Jun Song, Chang-Wook Ahn, Young Pyo Jang, Ki Sung Kang   +10 more
doaj   +1 more source