Results 101 to 110 of about 17,435 (223)

Evaluation of organ-specific relative biological effectiveness of proton therapy using radiation-induced pneumonitis as an endpoint

Clinical and Translational Radiation Oncology
Background and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy’s ...
Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J. Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang   +9 more
doaj   +1 more source

Why RBE must be a variable and not a constant in proton therapy [PDF]

, 2016
Purpose: This paper considers why the proton therapy relative biological effect (RBE) should be variable rather than constant. Methods: The reasons for a variable proton RBE are enumerated, with qualitative and quantitative arguments.

core   +1 more source

Determining RBE for development of lung fibrosis induced by fractionated irradiation with carbon ions utilizing fibrosis index and high-LET BED model

Clinical and Translational Radiation Oncology, 2019
Background and purposes: Carbon ion radiotherapy (CIRT) with raster scanning technology is a promising treatment for lung cancer and thoracic malignancies.
Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Bing Yang, Stephan Brons, Liji Cao, Ying Dai, Christian Schwager, Ming Chen, Oliver Jaekel, Longhua Chen, Juergen Debus, Amir Abdollahi   +12 more
doaj   +1 more source

Clinical radiobiology of proton therapy: modeling of RBE [PDF]

, 2017
Purpose: To better estimate relative biological effectiveness (RBE) in therapeutic proton beams by using a modeled approach, in order to improve their clinical safety and effectiveness.
B. Jones
core   +1 more source

Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? [PDF]

, 2018
PURPOSE To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ...
Jäkel, Oliver, Karger, Christian P, Oliver Jäkel, Clarissa Gillmann, Lomax, Antony J, Weber, Damien Charles, Antony J. Lomax, Gillmann, Clarissa, Damien C. Weber, Christian P. Karger, Gillmann C, Weber DC, Lomax, Antony J. (author), Karger, Christian P. (author), Jäkel, Oliver (author), Lomax AJ, Gillmann, Clarissa (author), Jäkel O, Weber, Damien C. (author), Karger CP   +19 more
core   +1 more source

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

Annals of Gastroenterological Surgery, Volume 10, Issue 6, Page 1788-1797, November 2026.
ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC).
Kenichiro Araki, Norio Kubo, Yuhei Miyasaka, Hayato Ikota, Ryo Muranushi, Mariko Tsukagoshi, Takamichi Igarashi, Masahiko Okamoto, Tatsuya Ohno, Ken Shirabe   +9 more
wiley   +1 more source

RBE physically associates with the TPL protein.

(A) Diagram of native RBE protein and RBE with point mutations in the EAR motif (mRBE). Native and altered amino acid sequences are shown. (B) Yeast two-hybrid assays between RBE or mRBE with TOPLESS (TPL).—symbol indicates only the AD domain.
Ruirui Huang (10360400), Vivian F. Irish (18107196)   +1 more
core   +1 more source

Development of smart packaging from rabbit skin gelatine incorporated with red beet (Beta vulgaris L.) extract: effects on physical and mechanical properties

World Rabbit Science
Rabbit skin is a promising source of gelatine due to its high collagen content, faster production and cost-efficiency compared to bovine gelatine, and halal status compared to porcine gelatine.
Qisthi Fadlilah Rahmi, Wendry Setiadi Putranto, Jajang Gumilar   +2 more
doaj   +1 more source

Spot size reduction and minibeam creation in a proton PBS nozzle using multipole permanent magnets

Medical Physics, Volume 53, Issue 11, November 2026.
Abstract Background Smaller spot sizes in pencil beam scanning (PBS) nozzles are generally desired to allow more conformal treatments and to spare normal tissue and organs at risk. The production of small diameter proton beams, especially proton minibeams, is challenging because long drift spaces in standard PBS nozzles exacerbate effects of MCS and ...
Grant A. McAuley
wiley   +1 more source

Relative Biological Effectiveness (RBE) of Monoenergetic Protons: Comparison of Empirical and Biophysical Models

Applied Sciences
A constant proton relative biological effectiveness (RBE) of 1.1 for tumor control is currently used in proton therapy treatment planning. However, in vitro, in vivo and clinical experiences indicate that proton RBE varies with kinetic energy and ...
Dimitris Dalalas, Alexis Papadopoulos, Ioanna Kyriakou, Robert D. Stewart, Pantelis Karaiskos, Dimitris Emfietzoglou   +5 more
doaj   +1 more source