Results 91 to 100 of about 13,471 (223)

Modelling dose and dose‐averaged linear energy transfer to predict high‐grade temporal lobe necrosis following skull‐base proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background In skull‐base proton therapy (PT), severe toxicity outcomes such as temporal lobe necrosis (TLN) may be associated with inadequate management of the actual radiobiological effectiveness (RBE) of proton beams. Combining dose‐averaged linear energy transfer (LETd) and dose may be crucial in treatment plan optimization and evaluation ...
Giulia Fontana, Elisa Fiorina, Sara Lillo, Lucia Pia Ciccone, Giulia Riva, Alessandro Vai, Mario Ciocca, Alberto Iannalfi, Silvia Molinelli, Ester Orlandi   +9 more
wiley   +1 more source

Rbe of Monoenergetic Fast Neutrons: Cytogenetic Effects in Maize [PDF]

, 1963
>The relative biological effectiveness (RBE) of neutrons of 5 energies and x radiation at 3 exposure levels were compared in maize seeds. The maize material used in these experiments had the advantsge for RBE studies of yielding a basically first order ...
Rossi, H. H., Smith, H. H., Bateman, J. L., Quastler, H.   +3 more
core   +1 more source

Feasibility of convection‐enhanced delivery of unlabeled 225Ac for glioblastoma: Transport, dosimetry, and clonogenic survival modeling

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Glioblastoma (GB) is an aggressive primary brain tumor with local recurrence rates exceeding 90% and a five‐year survival rate of approximately 5%. Standard treatments such as surgical resection, external beam radiotherapy (EBRT), and chemotherapy often leave residual tumor cells that are resistant to therapy.
Maram El Sabri, Leyla Moghaddasi, Puthenparampil Wilson, Frank Saran, Eva Bezak   +4 more
wiley   +1 more source

Data-driven RBE parameterization for helium ion beams [PDF]

, 2016
Helium ion beams are expected to be available again in the near future for clinical use. A suitable formalism to obtain relative biological effectiveness (RBE) values for treatment planning (TP) studies is needed.
Pedroni, P, Mairani, A, Ciocca, M, Galm, R, Böhlen, T T, Ferrari, A, Magro, G, Tessonnier, T, Parodi, K, Dokic, I, Haberer, T, Jäkel, O, Valle, S M   +12 more
core   +1 more source

Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness

Physics and Imaging in Radiation Oncology
Background and purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose.
Armin Lühr, Dirk Wagenaar, Daniëlle B.P. Eekers, Lars Glimelius, Steven J.M. Habraken, Semi Harrabi, Miranda C.A. Kramer, Ranald I. Mackay, Ana Vaniqui, Alexandru Dasu, Damien C. Weber   +10 more
doaj   +1 more source

Radiobiology studies of gold nanoparticle‐enhanced radiosensitization in proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
N. Fuster‐Martínez, D. H. Saucedo‐Cuberes, M. C. Jiménez‐Ramos, D. Esperante, J. M. Espino, J. Fuster, J. F. Belén‐Aguilar, L. González‐López, P. Huertas, S. Jimeno, I. Mingarro, D. Pascual, D. Suárez‐García, M. J. García‐Murria   +13 more
wiley   +1 more source

炭素線のRBE [PDF]

, 2003
Eric J. Hallの教科書によると生物効果比(RBE)は以下のように定義されている。 \nある放射線(r)を250kVＸ線と比較した時のRBEは、250kVＸ線と放射線(r)とが同じ生物効果を生じるのに必要な線量をD250,Dr,とすると、その比D250/ Drによって表される。 \n　HIMACで求めた最初のRBEは重粒子線治療の先駆けとして安藤らがマウス皮膚反応で求めた290MeV/u炭素線6cmSOBPの2.8という値である。 重粒子共同利用研究は ...
野島, 久美恵, 598769, 598768, 野島 久美恵   +3 more
core  

An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Nanodosimetry relates the cumulative or statistical moments of Ionization Detail (ID) with biological endpoints of relevance to cancer radiotherapy using charged particles. This association suggests to develop an additional physics‐detailed layer of modeling that may complement biological modeling and treatment planning.
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti, Naoki D‐Kondo, Oliver Jäkel, Bruce Faddegon, Niklas Wahl   +6 more
wiley   +1 more source

Hepatoprotective effects of Radix Bupleuri extract on aflatoxin B1-induced liver injury in ducks

Ecotoxicology and Environmental Safety
Aflatoxin B1 (AFB1) is recognized as the most toxic mycotoxin, widely present in nature and known to specifically target the liver, leading to severe consequences to animal and human health.
Tianyi Feng, Siyu Li, Pengpeng Wang, Di Zhu, Zhixiang Xu, Lidan Wang, Aoyun Li, Md. F. Kulyar, Yaoqin Shen   +8 more
doaj   +1 more source

Fractionated carbon ion irradiations of the rat spinal cord: comparison of the relative biological effectiveness with predictions of the local effect model

Radiation Oncology, 2020
Background To determine the relative biological effectiveness (RBE) and α/β-values after fractionated carbon ion irradiations of the rat spinal cord with varying linear energy transfer (LET) to benchmark RBE-model calculations.
Maria Saager, Christin Glowa, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus, Christian P. Karger   +7 more
doaj   +1 more source