Results 61 to 70 of about 13,471 (223)
Toward a theory of Bayesian experimentation in early‐stage ventures
Strategic Entrepreneurship Journal, EarlyView.Abstract Research Summary The entrepreneurship literature has established the benefits of experimentation but has paid comparatively little attention to its costs. We develop a Bayesian model to illustrate the entrepreneurial choice between direct and experimental entry.
Andrea Contigiani +2 more
wiley +1 more source
An updated variable RBE model for proton therapy [PDF]
Objective. While a constant relative biological effectiveness (RBE) of 1.1 forms the basis for clinical proton therapy, variable RBE models are increasingly being used in plan evaluation.
Lyngholm, Erlend +8 more
core +1 more source
Integrating microdosimetric in vitro RBE models for particle therapy into TOPAS MC using the MicrOdosimetry-based modeling for RBE Assessment (MONAS) tool [PDF]
, 2023 We present MONAS (MicrOdosimetry-based modelliNg for relative biological effectiveness (RBE) ASsessment) toolkit. MONAS is a TOPAS Monte Carlo extension, that combines simulations of microdosimetric distributions with radiobiological microdosimetry-based
Cartechini, Giorgio +4 more
core +1 more source
Molecules, 2021 Resveratrol butyrate esters (RBE) are derivatives of resveratrol (RSV) and butyric acid and exhibit biological activity similar to that of RSV but with higher bioavailability.
Ming-Kuei Shih +7 more
doaj +1 more source
Cancer Science, EarlyView.Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun +15 more
wiley +1 more source
Physics and Imaging in Radiation OncologyBackground and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg +8 more
doaj +1 more source
Cancer Science, EarlyView.The transporter‐associated BNCT strategy using BBCIP with or without BPA according to tumor transporter characteristics. BPA showed greater efficacy in LAT1‐dominant F98 glioma, whereas BBCIP was more effective in SMVT‐high CRL1666 tumors, suggesting the potential utility of transporter‐based boron carrier selection in BNCT.
Kenichiro Eza +15 more
wiley +1 more source
RBE physically associates with the TPL protein. [PDF]
(A) Diagram of native RBE protein and RBE with point mutations in the EAR motif (mRBE). Native and altered amino acid sequences are shown. (B) Yeast two-hybrid assays between RBE or mRBE with TOPLESS (TPL).—symbol indicates only the AD domain.
Ruirui Huang (10360400) +1 more
core +1 more source
Clinical radiobiology of proton therapy: modeling of RBE [PDF]
, 2017 Purpose: To better estimate relative biological effectiveness (RBE) in therapeutic proton beams by using a modeled approach, in order to improve their clinical safety and effectiveness.
Jones, Bleddyn, Jones, B, B. Jones
core +2 more sources
Oxidative stability of blesbok, springbok and fallow deer droëwors with added rooibos extract
South African Journal of Science, 2015 The addition of rooibos extract (RBE) (0%, 0.25%, 0.50%, 1.0% RBE) to improve the oxidative stability of blesbok, springbok and fallow deer droëwors (dried sausage) was studied. RBE treatments had no effects (p>0.05) on the lipid and protein oxidation of
Maxine Jones +2 more
doaj +1 more source