Results 1 to 10 of about 19,408 (157)

The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway [PDF]

Experimental and Molecular Medicine
Retinol-binding protein 4 (RBP4), the sole specific carrier for retinol (vitamin A) in circulation, is highly expressed in liver and adipose tissues. Previous studies have demonstrated that RBP4 plays a role in cold-mediated adipose tissue browning and ...
Jong Yoen Park, Eun Sun Ha, Jimin Lee, Pierre-Jacques Brun, Yeri Kim, Sung Soo Chung, Daehee Hwang, Seung-Ah Lee, Kyong Soo Park   +8 more
doaj   +4 more sources

The Prognostic Role of IL-6 and RBP4 in Colorectal Cancer [PDF]

Biomedicines
Background/Objectives: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Inflammation and metabolic dysregulation, particularly those related to obesity, have emerged as critical contributors to CRC progression ...
Małgorzata Żulicka, Daria Piątkowska, Dariusz Grzanka, Klaudia Bonowicz, Dominika Jerka, Maciej Gagat, Paulina Antosik   +6 more
doaj   +4 more sources

Optimised expression and purification of RBP4 and preparation of anti‐RBP4 monoclonal antibody

FEBS Open Bio, 2022
The expression level of retinol‐binding protein 4 (RBP4) protein is closely related to liver damage and plays an important role in the diagnosis and prognosis of cancer.
Hui Li, Xiao He, Sha Wen, Lichao Yang, Qiuli Chen, Yasi Li, Shiping Huang, Xuejing Huang, Fengjie Wan, Min He   +9 more
doaj   +2 more sources

Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through Multi-Omics and Mendelian Randomization Analysis. [PDF]

MedComm (2020)
We performed UPLC‐MS/MS lipidomics and DIA proteomics on plasma from healthy controls, active TB patients, and cured patients, and used Mendelian randomization to prioritize diagnostic and cure biomarkers. Multi‐omics random‐forest models based on these biomarkers showed excellent performance for diagnosis and cure monitoring.
Zhu C, Chen J, Li Y, Zhang Q, Lu Q, Zhang N, Fan H, Khakwani MMAK, Zhang L, Li JC.   +9 more
europepmc   +2 more sources

Association of baseline and longitudinal plasma retinol-binding protein 4 with all-cause mortality in maintenance hemodialysis patients [PDF]

Frontiers in Endocrinology
IntroductionElevated levels of retinol-binding protein 4 (RBP4) have been linked to conditions including cardiovascular disease, type 2 diabetes, obesity, and insulin resistance.
Thung-Lip Lee, Thung-Lip Lee, Chao-Ping Wang, Chao-Ping Wang, Chin-Feng Hsuan, Chin-Feng Hsuan, Chin-Feng Hsuan, Chia-Chang Hsu, Chia-Chang Hsu, Chia-Chang Hsu, Yung-Chuan Lu, Wei-Hua Tang, Wei-Hua Tang, Ching-Ting Wei, Ching-Ting Wei, Ya-Ai Cheng, Fu-Mei Chung, Yau-Jiunn Lee, I-Ting Tsai, I-Ting Tsai   +19 more
doaj   +2 more sources

Inhaled Halogen-Induced Oxidative Renal Damage and Dysfunction: A Lung Heart Kidney Axis. [PDF]

Compr Physiol
Mechanisms of lung‐heart‐kidney interaction in inducing organ injury after chemical inhalation. Acute exposure to halogen gases causes extensive lung injury and acute cardiac damage leading to fatalities. Formation of highly reactive halogenated molecules in the pulmonary bed and their circulation resulting in oxidative stress and inflammation was ...
Juncos JXM, Zaky A, Nasser W, Johns AJ, Zafar I, Jadhav GR, Foote JB, Ahmad A, Agarwal A, Ahmad S.   +9 more
europepmc   +2 more sources

Retinol-binding protein 4 in skeletal and cardiac muscle: molecular mechanisms, clinical implications, and future perspectives [PDF]

Frontiers in Cell and Developmental Biology
Retinol-binding protein 4 (RBP4) has emerged as a critical adipokine involved in the pathophysiology of metabolic and cardiovascular diseases. Beyond its classical role in retinol transport, RBP4 influences insulin resistance, inflammation, lipid ...
Kangzhen Zhang, Lijuan Wang, Wei Gao, Rong Guo   +3 more
doaj   +2 more sources

The Predictive Value of the Combination of Serum RBP4, ALP, IL-1β for Postoperative Recurrence of Intrahepatic Bile Duct Stones. [PDF]

Ther Clin Risk Manag
Tang W, Kang X, Zhou C, Chen C.
europepmc   +3 more sources

The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4 [PDF]

Chinese Medicine
Background Alcohol-related liver disease (ALD) is an important cause of the increase in liver disease-related morbidity and mortality worldwide. Its core pathological features are oxidative stress imbalance and lipid metabolism disorders.
Ru Xiao, Jiamin Fang, Qinpo Huang, Guolin He, Xia Ou, Yang De, Shuhua Gui, Yun Zhang, Maoci Wang, Yiyuan Zhong, Dawa Zeren, Yongling Long, Changhui Liu, Tianqin Xiong   +13 more
doaj   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source