RBP4 promotes denervation‐induced muscle atrophy through STRA6‐dependent pathway
Journal of Cachexia, Sarcopenia and MuscleBackgrounds Fat infiltration of skeletal muscle has been recognized as a common feature of many degenerative muscle disorders. Retinol binding protein 4 (RBP4) is an adipokine that has been demonstrated to be correlated with the presence and severity of ...
Kang‐Zhen Zhang +8 more
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The Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation
AntioxidantsObjectives: This study investigates the role of retinol binding protein 4 (RBP4) in an articular context. RBP4, a vitamin A transporter, is linked to various metabolic diseases.
Andrés Pazos-Pérez +10 more
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Biological Functions of RBP4 and Its Relevance for Human Diseases [PDF]
Frontiers in Physiology, 2021 Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff +3 more
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Clinical, genetic and biochemical signatures of RBP4-related ocular malformations
Journal of Medical Genetics, 2023 Background The retinoic acid (RA) pathway plays a crucial role in both eye morphogenesis and the visual cycle. Individuals with monoallelic and biallelic pathogenic variants in retinol-binding protein 4 (RBP4), encoding a serum retinol-specific transporter, display variable ocular phenotypes.
Plaisancié, Julie +12 more
openaire +6 more sources
Adipokine RBP4 drives ovarian cancer cell migration [PDF]
Journal of Ovarian Research, 2018 Background Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients and animals. Previously, we
Yanyan Wang, Yilin Wang, Zhenyu Zhang
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RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans[S] [PDF]
Journal of Lipid Research, 2009 We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate ...
Ying Wu +6 more
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Interleukin-1β downregulates RBP4 secretion in human adipocytes. [PDF]
PLoS ONE, 2013 AIMS/HYPOTHESIS: The excessive accumulation of adipose tissue in the obese state is linked to an altered secretion profile of adipocytes, chronic low-grade inflammation and metabolic complications.
Primoz Kotnik +3 more
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Diabetes, metabolic syndrome and obesity : targets and therapy, 2020 Pediatric obesity continues to remain a serious health concern which has significantly increased the morbidity risk in adulthood. Recent studies have analyzed the impact of the two adipokines, RBP4 (retinol binding protein 4) and STRA6 (stimulated by retinoic acid 6) in pediatric obese subjects with contradictory results.An observational study was ...
Boaghi,Anastasia +6 more
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Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization [PDF]
Journal of Neuroinflammation, 2023 Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophages (Mφs) play a key role.
Tianyi Shen +11 more
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Shift work is associated with an increased risk of type 2 diabetes and elevated RBP4 level: cross sectional analysis from the OHSPIW cohort study [PDF]
BMC Public Health, 2023 Background Shift work, with its growing prevalence globally, disrupts the body's inherent circadian rhythm. This disruption may escalate the risk of chronic diseasesxacerbate chronic disease risk by dysregulating physiological, behavioral, and ...
Li Wang +8 more
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