Results 21 to 30 of about 107,730 (50)

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction

Journal of Neuroinflammation, 2011
Background Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is capable of activating the small GTPase RhoA, which in turn contributes to endothelial barrier dysfunction.
Deng Xiaolu, Zhang Ciliu, He Fang, Peng Jing, Yin Fei   +4 more
doaj   +1 more source

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1

Journal of Neuroinflammation, 2009
Background Polymorphisms in the MHC class 1-like gene known as HFE have been proposed as genetic modifiers of neurodegenerative diseases that include neuroinflammation as part of the disease process.
Simmons Zachary, Randazzo William T, Lee Sang Y, Mitchell Ryan M, Connor James R   +4 more
doaj   +1 more source

Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance

Molecular Brain, 2011
Opiate drugs are the most effective analgesics available but their clinical use is restricted by severe side effects. Some of these undesired actions appear after repeated administration and are related to adaptive changes directed at counteracting the ...
Nagi Karim, Piñeyro Graciela
doaj   +1 more source

Role of platelets in neuroinflammation: a wide-angle perspective

Journal of Neuroinflammation, 2010
Objectives This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide.
Etemadifar Masoud, Maghzi Amir H, Zivadinov Robert, Ahn Yeon S, Jy Wenche, Horstman Lawrence L, Steven Alexander J, Minagar Alireza   +7 more
doaj   +1 more source

Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus

Frontiers in Neurology, 2020
Ripple oscillations (80–200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200–600 Hz) rates serve as a biomarker of epileptogenic brain.
Shennan A. Weiss, Inkyung Song, Mei Leng, Tomás Pastore, Diego Slezak, Zachary Waldman, Iren Orosz, Richard Gorniak, Mustafa Donmez, Ashwini Sharan, Chengyuan Wu, Itzhak Fried, Michael R. Sperling, Anatol Bragin, Jerome Engel, Jerome Engel, Jerome Engel, Jerome Engel, Yuval Nir, Richard Staba   +19 more
doaj   +1 more source

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

Journal of Neuroinflammation, 2009
Background A causal role of the complement system in Alzheimer's disease pathogenesis has been postulated based on the identification of different activated components up to the membrane attack complex at amyloid plaques in brain.
Wiederhold Karl-Heinz, Danner Simone, Reichwald Julia, Staufenbiel Matthias   +3 more
doaj   +1 more source

Coordinated trafficking of synaptic vesicle and active zone proteins prior to synapse formation

Neural Development, 2011
Background The proteins required for synaptic transmission are rapidly assembled at nascent synapses, but the mechanisms through which these proteins are delivered to developing presynaptic terminals are not understood. Prior to synapse formation, active
Sabo Shasta L, Bury Luke AD
doaj   +1 more source

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

Journal of Neuroinflammation, 2013
Background The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the bark of Magnolia officinalis, and ...
Chuang Dennis Y, Chan Ming-Huan, Zong Yijia, Sheng Wenwen, He Yan, Jiang Jing Hua, Simonyi Agnes, Gu Zezong, Fritsche Kevin L, Cui Jiankun, Lee James C, Folk William R, Lubahn Dennis B, Sun Albert Y, Sun Grace Y   +14 more
doaj   +1 more source

Assessment of Intracranial Collateral Circulation Using Novel TCCS Grading System in Patients With Symptomatic Carotid Occlusion

Frontiers in Neurology, 2020
Objectives: To establish a novel transcranial color-coded sonography (TCCS) grading system for collateral circulation in cases of symptomatic chronic total carotid occlusion (TCO), and to correlate this new grading system with cerebrovascular reserve ...
Foad Abd-Allah, Haytham Rizk, Mohammad Ahmed Farrag, Mohamed Hafez Shaaban, Ahmed Nasreldein   +4 more
doaj   +1 more source

A new approach to estimation of the number of central synapse(s) included in the H-reflex

BMC Neurology, 2005
Background Among the main clinical applications of the H-reflex are the evaluation of the S1 nerve root conductivity such as radiculopathy and measurement of the excitability of the spinal motoneurons in neurological conditions.
Sadeghi Shahram, Ashraf Alireza, Ghavanini Mohammadreza, Emad Mohammadreza   +3 more
doaj   +1 more source