Results 91 to 100 of about 45,973 (207)

Rituximab-Containing Treatment Regimens May Imply a Long-Term Risk for Difficult-To-Treat Chronic Hepatitis E [PDF]

open access: yes, 2020
Hepatitis E virus (HEV) infection is an emerging disease in industrialized countries which is usually characterized by a self-limited course. However, there is an increased risk of HEV persistence in immunocompromised risk populations, comprising ...
Biedermann, Paula   +7 more
core   +1 more source

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen   +10 more
wiley   +1 more source

Crystallisation of Zika NS5 RdRp v1

open access: yes
The main aim of this work was to identify small molecules that bind Zika NS5 RdRp (catalytic RNA-dependent RNA polymerase domain) through X-ray fragment-based screening. The Zika NS5 RDRP domain was cloned, expressed, purified, and crystallised. Suitable crystals for fragment screening were produced and optimised allowing an extensive fragment ...
Anu V. Chandran   +2 more
openaire   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu   +8 more
wiley   +1 more source

Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]

open access: yes, 2008
The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.)   +3 more
core  

Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.

open access: yesPLoS ONE, 2021
To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed.
Clément Madru   +6 more
doaj   +1 more source

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang   +8 more
wiley   +1 more source

Tomato marchitez virus, a new plant picorna-like virus from tomato related to tomato torrado virus [PDF]

open access: yes
A new virus was isolated from a tomato plant from the state of Sinaloa in Mexico. This plant showed symptoms locally known as `marchitez disease¿: severe leaf necrosis, beginning at the base of the leaflets, and necrotic rings on the fruits.
Dullemans, A.M.   +4 more
core   +2 more sources

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

open access: yes, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna   +3 more
core   +1 more source

Coronavirus Detection in Bats Captured on the Deforestation Arc of Mato Grosso, Brazil

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Coronaviruses (CoV) are RNA viruses associated with enteric and respiratory diseases and known for their emergence potential in humans and other mammals. CoVs originate from zoonotic transmission, in which bats are natural reservoirs. Previous studies suggest that CoV diversity is positively correlated with bat diversity, whereas anthropogenic
Matheus Augusto Calvano Cosentino   +5 more
wiley   +1 more source

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