Results 151 to 160 of about 28,840 (175)

Lipidomics reveals the pro-viral roles of ceramides during fish nodavirus infection. [PDF]

J Virol
Zhang Y, Liu L, Lin L, Zhao Y, Xi K, Guo X, Qin Q, Huang X, Huang Y.   +8 more
europepmc   +1 more source

Genetic Diversity of Norovirus and Sapovirus Outbreaks in Long-Term Care Facilities in Quebec, Canada, 2011-2016. [PDF]

Viruses
Larocque É, L'Homme Y, Charest H, Martineau C.   +3 more
europepmc   +1 more source

Diverse virome and potential pathogens in five tick species from metropolis surroundings of Beijing and Tianjin, China. [PDF]

NPJ Biofilms Microbiomes
Gao WY, Xia X, Wang TH, Liu YT, Wang J, Li YY, Xia LY, Jia N, Jiang JF, Sun Y, Cui XM, Ye RZ, Zhao L, Cao WC.   +13 more
europepmc   +1 more source

Giant grouper nervous necrosis virus subgenomic RNA3 is transcribed by a premature termination mechanism via intragenomic RNA-RNA pairing. [PDF]

Virol J
Cheng CA, Lai CS, Liao FE, Yeh SL, Chiang MH, Li CH, Fang KY, Liao YC, Hsu HC, Bajpai V, Chi CK, Chen CW, Liu HW, Chang CC, Chang CY.   +14 more
europepmc   +1 more source

Comparative Analysis of Codon Usage Patterns and Host Adaptation in <i>Merbecoviruses</i>. [PDF]

Viruses
Yan G, Li Y, Zhou H, Franzo G, Zheng M, Liu H, Chen X, Dai J, He WT.   +8 more
europepmc   +1 more source

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HCV RdRp, sofosbuvir and beyond

2021
The therapeutic targeting of the nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) of the Hepatitis C Virus (HCV) with nucleotide analogs led to a deep understanding of this enzymes structure, function and substrate specificity. Unlike previously studied DNA polymerases including the reverse transcriptase of Human Immunodeficiency ...
Joy Y, Feng, Adrian S, Ray
openaire   +2 more sources

Cinnamic acid inhibits Zika virus by inhibiting RdRp activity

Antiviral Research, 2021
In recent years, Zika virus (ZIKV), which causes severe diseases such as congenital microcephaly and Guillain-Barré syndrome, bringing serious harm to humans, has spread throughout the world. However, there are currently no effective drugs against the virus, and the need to develop anti-ZIKV drugs is thus urgent.
Yuting Chen, Zhaoxin Li, Pan Pan, Zizhao Lao, Jiangtao Xu, Zonghui Li, Shaofeng Zhan, Xiaohong Liu, Yina Wu, Wenbiao Wang, Geng Li   +10 more
openaire   +2 more sources

Fluorometric RdRp assay with self-priming RNA

Virus Genes, 2015
There is an outmost need for the identification of specific antiviral compounds. Current antivirals lack specificity, making them susceptible to off-target effects, and highlighting importance of development of assays to discover antivirals targeting viral specific proteins.
Fatih, Kocabas, Raife D, Turan, Galip S, Aslan   +2 more
openaire   +2 more sources

Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery

Critical Reviews in Microbiology, 2017
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss.
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat   +3 more
openaire   +2 more sources