Results 161 to 170 of about 29,350 (193)
RdRp inhibitors and COVID-19: Is molnupiravir a good option?
Biomedicine and Pharmacotherapy, 2022 Rapid changes in the viral genome allow viruses to evade threats posed by the host immune response or antiviral drugs, and can lead to viral persistence in the host cells. RNA-dependent RNA polymerase (RdRp) is an essential enzyme in RNA viruses, which is involved in RNA synthesis through the formation of phosphodiester bonds.
Seyed Mohammadreza Hashemian +2 more
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HCV RdRp, sofosbuvir and beyond
2021The therapeutic targeting of the nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) of the Hepatitis C Virus (HCV) with nucleotide analogs led to a deep understanding of this enzymes structure, function and substrate specificity. Unlike previously studied DNA polymerases including the reverse transcriptase of Human Immunodeficiency ...
Joy Y, Feng, Adrian S, Ray
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Fluorometric RdRp assay with self-priming RNA
Virus Genes, 2015There is an outmost need for the identification of specific antiviral compounds. Current antivirals lack specificity, making them susceptible to off-target effects, and highlighting importance of development of assays to discover antivirals targeting viral specific proteins.
Fatih, Kocabas +2 more
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Cinnamic acid inhibits Zika virus by inhibiting RdRp activity
Antiviral Research, 2021In recent years, Zika virus (ZIKV), which causes severe diseases such as congenital microcephaly and Guillain-Barré syndrome, bringing serious harm to humans, has spread throughout the world. However, there are currently no effective drugs against the virus, and the need to develop anti-ZIKV drugs is thus urgent.
Yuting Chen +10 more
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Genomic characterization of a nebovirus strain with a novel RdRp genotype in yaks
Archives of Virology, 2021Neboviruses (NeVs) are important causative agents of calf diarrhea that belong to the family Caliciviridae. In this study, we investigated the genomic characteristics of a NeV strain from yaks that has a novel RdRp genotype. The complete genome of this strain (YAK/NRG-A9/19/CH) is 7454 nt in length and shares 68.3%-79.7% nt sequence identity with those
Siyi Li +4 more
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Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery
Critical Reviews in Microbiology, 2017Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss.
Abdennour Amroun +3 more
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Copper mediated RDRP of thioacrylates and their combination with acrylates and acrylamides
Polymer Chemistry, 2019Ethyl thioacrylate was polymerised via Cu-RDRP and subjected to amidation to obtain the first “all-acrylic” copolymer.
Suzan Aksakal +3 more
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[Characterization of RdRp gene of rabies virus in China].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2009Characterization of RdRp gene (L) of rabies virus aG and CTN181 strain in China.Overlapped fragments were amplified and assembled. Then characterization and phylogenetic analyses as well as prediction of functional regions were performed using biologic softwares.L gene of CTN181 and aG strains were composed with 6387nt and 6384nt respectively and there
Jia-Liang, Du +5 more
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High genetic diversity in RdRp gene of Brazilian porcine sapovirus strains
Veterinary Microbiology, 2008Sapovirus is one genus within Caliciviridae family that causes diarrhea in humans and animals. Sapovirus (SaV) has been classified into seven genogroups (GI to GVII). The GIII, GVI, and GVII, which prototype is Cowden, JJ681, and K7/JP strains, respectively, infect pigs.
Aline F, Barry +2 more
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Deeper Insight Into the RDRP Polymerization of Vinylidene Fluoride
2017Two strategies of RDRP of vinylidene fluoride (VDF) are presented. First, in contrast to the MADIX copolymerization of VDF with other comonomers (TFP, PMVE, and MAF), 1 that of VDF has been very rarely reported 2-3The synthesis of PVDF usingMADIX solution polymerization was thus investigated in details More efficient protocols of solution ...
Guerre, Marc +2 more
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