Results 151 to 160 of about 29,952 (187)
Exploring RdRp–remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV [PDF]
SAR and QSAR in Environmental Research, 2020 A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has resulted in an increasing number of patients globally, and has become a highly lethal pathogenic member of the coronavirus family affecting humans. 2019-nCoV has established itself as one of the most threatening pandemics that human beings have faced, and therefore analysis and ...
Ravindra Rawal +2 more
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RdRp inhibitors and COVID-19: Is molnupiravir a good option?
Biomedicine and Pharmacotherapy, 2022 Rapid changes in the viral genome allow viruses to evade threats posed by the host immune response or antiviral drugs, and can lead to viral persistence in the host cells. RNA-dependent RNA polymerase (RdRp) is an essential enzyme in RNA viruses, which is involved in RNA synthesis through the formation of phosphodiester bonds.
Michael R Hamblin +2 more
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HCV RdRp, sofosbuvir and beyond
2021The therapeutic targeting of the nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) of the Hepatitis C Virus (HCV) with nucleotide analogs led to a deep understanding of this enzymes structure, function and substrate specificity. Unlike previously studied DNA polymerases including the reverse transcriptase of Human Immunodeficiency ...
Joy Y, Feng, Adrian S, Ray
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Fluorometric RdRp assay with self-priming RNA
Virus Genes, 2015There is an outmost need for the identification of specific antiviral compounds. Current antivirals lack specificity, making them susceptible to off-target effects, and highlighting importance of development of assays to discover antivirals targeting viral specific proteins.
Fatih, Kocabas +2 more
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Genomic characterization of a nebovirus strain with a novel RdRp genotype in yaks
Archives of Virology, 2021Neboviruses (NeVs) are important causative agents of calf diarrhea that belong to the family Caliciviridae. In this study, we investigated the genomic characteristics of a NeV strain from yaks that has a novel RdRp genotype. The complete genome of this strain (YAK/NRG-A9/19/CH) is 7454 nt in length and shares 68.3%-79.7% nt sequence identity with those
Siyi Li +4 more
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Cinnamic acid inhibits Zika virus by inhibiting RdRp activity
Antiviral Research, 2021In recent years, Zika virus (ZIKV), which causes severe diseases such as congenital microcephaly and Guillain-Barré syndrome, bringing serious harm to humans, has spread throughout the world. However, there are currently no effective drugs against the virus, and the need to develop anti-ZIKV drugs is thus urgent.
Yuting Chen +10 more
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Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery
Critical Reviews in Microbiology, 2017Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss.
Abdennour Amroun +3 more
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Copper mediated RDRP of thioacrylates and their combination with acrylates and acrylamides
Polymer Chemistry, 2019Ethyl thioacrylate was polymerised via Cu-RDRP and subjected to amidation to obtain the first “all-acrylic” copolymer.
Suzan Aksakal +3 more
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