Results 51 to 60 of about 53,016 (292)

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain

Chemical Physics Letters, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain.
Eleni Pitsillou, Julia Liang, Helen Yu Meng Huang, Andrew Hung, Tom C. Karagiannis   +4 more
openaire   +2 more sources

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

Viruses, 2023
Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale, Robin J. Larson, Erin Jackson-Ward, Aditi Singh, Frances L. Koback, Lilly D. Engineer   +5 more
doaj   +1 more source

Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp) Mechanism. [PDF]

J Chem Theory Comput
Roca M, Maghsoud Y, Cisneros GA, Świderek K, Moliner V.   +4 more
europepmc   +2 more sources

ICTV Virus Taxonomy Profile: Chrysoviridae [PDF]

, 2018
The Chrysoviridae is a family of small, isometric, non-enveloped viruses (40 nm in diameter) with segmented dsRNA genomes (typically four segments). The genome segments are individually encapsidated and together comprise 11.5–12.8 kbp.
Bradley I. Hillman, Dae-Hyun Kim, Daohong Jiang, Ghabrial, Hiromitsu Moriyama, José R. Castón, Robert H. A. Coutts, Said A. Ghabrial   +7 more
core   +2 more sources

A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus

Microchimica Acta, 2021
A voltammetric genosensor has been developed for the early diagnosis of COVID-19 by determination of RNA-dependent RNA polymerase (RdRP) sequence as a specific target of novel coronavirus.
L. Farzin, S. Sadjadi, Azarmidokht Sheini, Elham Mohagheghpour   +3 more
semanticscholar   +1 more source

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study [PDF]

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one of the targeted approach.
J. Ahmad, S. Ikram, Fawad Ahmad, I. Rehman, M. Mushtaq   +4 more
semanticscholar   +4 more sources

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data [PDF]

Briefings in Bioinformatics, 2022
Abstract With advances in library construction protocols and next-generation sequencing technologies, viral metagenomic sequencing has become the major source for novel virus discovery. Conducting taxonomic classification for metagenomic data is an important means to characterize the viral composition in the underlying samples.
Tang, Xubo, Shang, Jiayu, Sun, Yanni
openaire   +2 more sources

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity [PDF]

Polymer Chemistry, 2018
The optimisation of all components within Cu(0)-wire mediated polymerisation of styrene is illustrated yielding well-defined polystyrene with enhanced initiator efficiency and dispersity at higher molecular weights.
Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton   +3 more
openaire   +3 more sources