Results 51 to 60 of about 2,150 (202)
RNA interference and Register Machines (extended abstract) [PDF]
EPTCS 100, 2012, pp. 107-112, 2012 RNA interference (RNAi) is a mechanism whereby small RNAs (siRNAs) directly control gene expression without assistance from proteins. This mechanism consists of interactions between RNAs and small RNAs both of which may be single or double stranded. The target of the mechanism is mRNA to be degraded or aberrated, while the initiator is double stranded ...
arxiv +1 more source
Ultra-low volume oxygen tolerant photoinduced Cu-RDRP [PDF]
Polymer Chemistry, 2019 We introduce the first oxygen tolerant ultra-low volume (as low as 5 μL) photoinduced Cu-RDRP of a range of hydrophobic, hydrophilic and semi-fluorinated monomers.
Evelina Liarou +8 more
openaire +3 more sources
MicroRNA‐205‐5p: A potential therapeutic target for influenza A
Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5917-5928, December 2022., 2022 Abstract We are committed to finding host targets for influenza A therapeutics. The nucleoprotein (NP) plays an important role in influenza A virus replication and is an indispensable part of viral transcription and replication. Exploring endogenous substances that can modulate NP is critical for finding host targets.
Yanyan Bao +9 more
wiley +1 more source
FEBS Open Bio, 2014 Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind +2 more
doaj +1 more source
In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 [PDF]
, 2020 Virtual screening of phytochemicals was performed through molecular docking, simulation, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, total 154 phytochemicals with analogous structure from limonoids and triterpenoids ...
arxiv +1 more source
Photo-induced copper-RDRP in continuous flow without external deoxygenation [PDF]
Polymer Chemistry, 2019 Photo-induced Cu-RDRP of acrylates in a continuous flow reactor without the need for deoxygenation or externally added reagents.
Arkadios Marathianos +6 more
openaire +3 more sources
Biophysical Chemistry, 2021 Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. Since developing antiviral drugs is a time-consuming process, the most effective approach is to evaluate the approved and under investigation drugs using in silico methods. Among the different targets within the virus structure, as a vital component in the life
Poustforoosh, A. +5 more
openaire +2 more sources
Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching [PDF]
Journal of Virology, 2019 Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1).
Ariga Tahmasian Sevarany +7 more
openaire +3 more sources
PLoS ONE, 2021 Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have exhibited the potential effect of small molecules.
Shruti Koulgi +4 more
doaj +1 more source
Molecular Plant Pathology, Volume 24, Issue 1, Page 71-79, January 2023., 2023 This study demonstrates that a foxtail mosaic virus vector induces robust gene silencing in sorghum through targeting of two marker genes and a subgroup of receptor‐like cytoplasmic kinases with roles in bacterial defence. Abstract Sorghum is vulnerable to many biotic and abiotic stresses, which cause considerable yield losses globally.
Melissa Bredow +5 more
wiley +1 more source