Results 51 to 60 of about 45,973 (207)
PLoS ONE, 2021 Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have exhibited the potential effect of small molecules.
Shruti Koulgi +4 more
doaj +1 more source
Advanced Science, 2023 Photoinduced reversible deactivation radical polymerization (photo‐RDRP) or photoinduced controlled/living radical polymerization has emerged as a versatile and powerful technique for preparing functional and advanced polymer materials under mild ...
Zilong Wu, Cyrille Boyer
doaj +1 more source
Analysis of RdRp Gene in SARS CoV-2 Variants
International Journal of Research and Review, 2023 SARS CoV-2 was discovered in Wuhan, China, in December 2019 and has since mutated into new variants. One of the genes that mutated in SARS CoV-2 is RNA-dependent RNA polymerase (RdRp), a gene playing roles in viral replication and transcription. This study aimed to determine the variation of the RdRp gene in the SARS CoV-2 variant.
SM Rezvi +2 more
openaire +1 more source
Identification and sequence determination of a novel double-stranded RNA mycovirus from the entopathogenic fungus Beauveria bassina [PDF]
, 2015 The final publication is available at Springer via https://doi.org/10.1007/s00705-014-2332-8.An isolate of the entomopathogenic fungus Beauveria bassiana was found to contain five double-stranded (ds) RNA elements ranging from 1.5 to more than 3 kbp. The
Coutts, Robert H.A. +2 more
core +1 more source
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
Acta Pharmaceutica Sinica B, 2021 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health. The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals, whereas nucleoside analogs inhibitor is hindered by the ...
Quanjie Li +16 more
doaj +1 more source
Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure [PDF]
PeerJ, 2020 The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate.
Gyanendra Bahadur Chand +2 more
doaj +2 more sources
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, EarlyView.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
core
Identification, Molecular Characterization, and Biology of a Novel Quadrivirus Infecting the Phytopathogenic Fungus Leptosphaeria biglobosa. [PDF]
, 2018 Here we report the molecular characterisation of a novel dsRNA virus isolated from the filamentous, plant pathogenic fungus Leptosphaeria biglobosa and known to cause significant alterations to fungal pigmentation and growth and to result in ...
Coutts, Robert +3 more
core +2 more sources
Frontiers in Microbiology, 2019 The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj +1 more source