Results 101 to 110 of about 1,607,122 (265)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Understanding the catalytic performance and stability of titania-containing silica catalysts in methyl oleate epoxidation for sustainable biorefinery processes

Journal of King Saud University: Engineering Sciences
Biomass is a renewable and eco-friendly alternative to fossil fuels and can contribute substantially to achieve an efficient industrial symbiosis. Specifically, vegetable oils conversion to biofuels is an attractive alternative to fossil fuels.
Rafik Rajjak Shaikh, Warinya Sukkaew, Supareak Praserthdam, Piyasan Praserthdam   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Electrocatalytic overall water splitting based on (ZnNiCoFeY)xOy high-entropy oxide supported on MoS2

South African Journal of Chemical Engineering
Hydrogen energy is a sustainable and clean source that can meet global energy demands without adverse environmental impacts. High-entropy oxides (HEOs), multielement (5 or more) oxides with an equiatomic or near-equatomic elemental composition, offer a ...
Sumayya C. Pathan, Jasmin S. Shaikh, Navajsharif S. Shaikh, Victor Márquez, Meena Rittiruam, Tinnakorn Saelee, Patcharaporn Khajondetchairit, Sawanta S. Mali, Jyoti V. Patil, Chang Kook Hong, Piyasan Praserthdam, Supareak Praserthdam   +11 more
doaj   +1 more source

Stabilization of Cereibacter sphaeroides Photosynthetic Reaction Center by the Introduction of Disulfide Bonds. [PDF]

Membranes (Basel), 2023
Selikhanov G, Atamas A, Yukhimchuk D, Fufina T, Vasilieva L, Gabdulkhakov A.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MODELS FOR ANTENNA AND REACTION CENTER CHLOROPHYLLS* [PDF]

Annals of the New York Academy of Sciences, 1975
Norris, J. R., Scheer, Hugo, Katz, J. J.
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Generic Interpretable Reaction Condition Predictions with Open Reaction Condition Datasets and Unsupervised Learning of Reaction Center. [PDF]

Research (Wash D C), 2023
Wang X, Hsieh CY, Yin X, Wang J, Li Y, Deng Y, Jiang D, Wu Z, Du H, Chen H, Li Y, Liu H, Wang Y, Luo P, Hou T, Yao X.   +15 more
europepmc   +1 more source