Results 111 to 120 of about 4,838,205 (202)

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, Volume 13, Issue 59, 23 October 2026.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Invasive Species Definition Clarification and Guidance White Paper

, 2006
Paper discussing a "a non-regulatory policy interpretation of the term invasive species" through a positional defintion of what and what does not constittue an invasive species along with examples of impacts caused by invasive species.
Definitions Subcommittee of the Invasive Species Adivsory Committee
core  

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, Volume 13, Issue 59, 23 October 2026.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, Volume 13, Issue 60, 28 October 2026.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Klenerman, D, Shchepinov, MS, Gandhi, S, Angelova, PR, Horrocks, MH, Abramov, AY   +5 more
core  

K+ Channels in Membrane Potential Dynamics and Migration of Neutrophil Granulocytes

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
Neutrophil membrane potential dynamics regulate directed migration. Kir2.1 regulates neutrophil membrane potential and indirectly LTB4 secretion. Together with KCa3.1 and KV1.3, it is required for efficient chemotaxis. KCa3.1 and KV1.3 influence neutrophil migration without altering membrane potential, potentially through reduced LTB4 release (KCa3.1 ...
Tahir Ulu, Henrik Siemer, Alexa Heuer, Sandra Schimmelpfennig, Peter Dieterich, Jesús Borrego, György Panyi, Albrecht Schwab   +7 more
wiley   +1 more source

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

Physiological Postnatal Neurogenesis, Development, and Maturation in the Regenerable Retina

Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.
Retinal structural remodeling from hatchlings to preadults in axolotls involves neurogenesis, cell redistribution, increased expression of photopsins and connexins, and enhanced inhibitory regulation. The peripheral retina of young animals possesses more columnar undifferentiated cells, resembling the columnar DCX‐positive progenitor cells in the ...
Vivian Y. Pang, Wenhui Zhong, Zhuo Yang, Samuel Wu, Ji‐Jie Pang   +4 more
wiley   +1 more source

Endogenous Protein Tagging in Postmitotic Neurons via Lentiviral and Adeno‐associated Virus Delivery

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract This protocol describes a method for endogenous protein tagging in postmitotic primary neurons using homology‐independent targeted integration (HITI), a CRISPR/Cas9‐based approach that exploits non‐homologous end joining (NHEJ). Unlike homology‐directed repair (HDR), HITI does not require cell division, making it uniquely suited for ...
Lorena Benedetti, Hyun Ah Yi, Lihua Wang, Jennifer Lippincott‐Schwartz   +3 more
wiley   +1 more source

Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms

Ecology and Evolution, Volume 16, Issue 10, October 2026.
1. Positive selection on PER2 phosphorylation regulators in atypical circadian mammals. 2. Dolphin CSNK1E enhances PER2 phosphorylation at the stabilizing S662 site and extends PER2 half‐life. 3. Dolphin CSNK1E increases locomotor activity and reduces sleep in zebrafish.
Yujie Chong, Qingqing Liu, Haojia Jiang, Linxue Tan, Huan Chen, Wenhua Ren, Shixia Xu, Guang Yang, Daiqing Yin   +8 more
wiley   +1 more source