Results 121 to 130 of about 4,838,205 (202)

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Interactome data

Interactome ...
Yue Xiao (17765673)
core   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

P023 | SETD2 loss in chronic myeloid leukemia promotes metabolic reprogramming and genomic instability leading to therapeutic resistance and disease progression

Haematologica
Chronic myeloid leukemia (CML) is driven by the Ph chromosome, but additional genetic abnormalities (AGAs) such as ASXL1 mutations and other cytogenetic alterations contribute to poor prognosis and reduced treatment response. SETD2 plays a critical role
Manuela Mancini
doaj  

Network Biology: Current Status, Applications, Challenges, and Future Prospects

MedComm, Volume 7, Issue 10, October 2026.
Network biology integrates molecular interaction, intracellular regulatory, single‐cell and multicellular, microbial and host–microbiome, disease, and interorgan networks across biological scales. Perturbation models, multiomics, spatial profiling, computational inference, mechanistic modeling, and AI enable dynamic network reconstruction and causal ...
Xinmeng Li, Laizhong Zhang, Yawen Ding, Kai Li, Shiyuan Chang, Linsen Pei, Zhengwei Li, Zhenzhen Chen   +7 more
wiley   +1 more source

A High‐Throughput SPR‐Based Array for Quantitative Profiling of Glycosaminoglycan–Protein Interactions

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Glycosaminoglycans (GAGs) are linear, negatively charged, polysaccharides that mediate a wide variety of biologically critical interactions with proteins, underpinning growth factor signaling, extracellular matrix assembly, and numerous disease processes.
Holly L. Birchenough, Jonathan F. Popplewell, H. Davies‐Strickleton, Douglas Dyer, Anthony J. Day, Thomas A. Jowitt   +5 more
wiley   +1 more source

Proximity Proteomics Maps Candidate Cellular Uptake Pathways for Cell‐Derived Nanovesicles

Small Methods, Volume 10, Issue 19, 7 October 2026.
TurboID‐based dual‐sided proteomics compares mechanically generated cell‐derived nanovesicles with naturally secreted small extracellular vesicles. Vesicle proteomes define candidate interaction signatures, while recipient‐cell proximity labelling identifies exposure‐associated proteins.
Eisuke Kanao, Ryosuke Mizuta, Saki Tarao, Yukika Hara, Yuka Li, Kazunari Akiyoshi, Yasushi Ishihama, Koshi Imami, Yoshihiro Sasaki   +8 more
wiley   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

A proteomic analysis of the PHF-forming tau fragment (tau297-391) following uptake into differentiated human neuronal SHSY5Y cells. [PDF]

Biosci Rep
Copsey A, Oakley SS, Maina MB, Parker R, Marshall KE, Harrington CR, Storey JMD, Wischik CM, Serpell LC.   +8 more
europepmc   +1 more source