Results 61 to 70 of about 156,055 (260)

Potential Role of Sulfur-Containing Antioxidant Systems in Highly Oxidative Environments

Molecules, 2014
All forms of life maintain a reducing environment (homeostasis) within their cells. Perturbations in the normal redox state can lead to an oxidative environment which has deleterious effects, especially in health.
Emmanuel Mukwevho, Zané Ferreira, Ademola Ayeleso   +2 more
doaj   +1 more source

Chemical evolution of turbulent protoplanetary disks and the Solar nebula

, 2011
This is the second paper in a series where we study the influence of transport processes on the chemical evolution of protoplanetary disks. Our analysis is based on a flared alpha-model of the DM Tau system, coupled to a large gas-grain chemical network.
Aikawa, Aikawa, Aikawa, Aikawa, Aikawa, Andrews, Bauer, Bergin, Bergin, Bethell, Biver, Bockelée-Morvan, Boss, Bradley, Brownlee, Calvet, Cant, Cazaux, Chapillon, Crabtree, D'Alessio, d'Hendecourt, D. Semenov, D. Wiebe, Dickens, Duschl, Dutrey, Dutrey, Dutrey, Finocchi, Fogel, Fukagawa, Gail, Garrod, Glassgold, Glassgold, Glassgold, Glassgold, Gorti, Gorti, Greenberg, Greenberg, Harada, Hasegawa, Heinzeller, Henning, Hersant, Hirose, Hughes, Juhász, Jørgensen, Kalenskii, Kamp, Katz, Kim, Lahuis, Lee, Lee, Lee, Leger, Lynden-Bell, Mazzitelli, Meijerink, Najita, Najita, Pagani, Pascucci, Perez-Becker, Pierce, Pontoppidan, Pontoppidan, Pontoppidan, Prinn, Qi, Qi, Sakai, Salyk, Salyk, Sarrasin, Savin, Schräpler, Semenov, Semenov, Shakura, Shalabiea, Simon, Terada, Turner, Turner, Vasyunin, Vasyunin, Vasyunin, Wakelam, Wakelam, Walsh, Willacy, Willacy, Wolf, Wooden, Wooden, Woods, Woods, Zasowski, Öberg   +103 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis

Redox Biology, 2018
Products of ultraviolet (UV) irradiation such as reactive oxygen species (ROS) and nitric oxide (NO) stimulate melanin synthesis. Reactive sulfur species (RSS) have been shown to have strong ROS and NO scavenging effects. However, the instability and low
Mayumi Ikeda, Yu Ishima, Ryo Kinoshita, Victor T.G. Chuang, Nanami Tasaka, Nana Matsuo, Hiroshi Watanabe, Taro Shimizu, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama   +10 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action

Redox Biology, 2023
Cardiotoxicity is a frequent and often lethal complication of doxorubicin (DOX)-based chemotherapy. Here, we report that hydropersulfides (RSSH) are the most effective reactive sulfur species in conferring protection against DOX-induced toxicity in H9c2 ...
Blaze M. Pharoah, Chengximeng Zhang, Vinayak S. Khodade, Gizem Keceli, Christopher McGinity, Nazareno Paolocci, John P. Toscano   +6 more
doaj   +1 more source

Organosulfate Formation in Biogenic Secondary Organic Aerosol [PDF]

, 2008
Organosulfates of isoprene, α-pinene, and β-pinene have recently been identified in both laboratory-generated and ambient secondary organic aerosol (SOA).
Chan, Arthur W. H., Claeys, Magda, Edney, Edward O., Flagan, Richard C., Gómez-González, Yadlan, Jaoui, Mohammed, Kleindienst, Tadeusz E., Lewandowski, Michael, Maenhaut, Willy, Offenberg, John H., Seinfeld, John H., Shahgholi, Mona, Surratt, Jason D., Vermeylen, Reinhilde   +13 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Ozone Oxidizes Glutathione to a Sulfonic Acid [PDF]

, 2009
Biosurfaces are universally covered with fluid microfilms containing reduced glutathione (GSH) and other antioxidants whose putative roles include the detoxification of ambient ozone (O_3).
Colussi, A. J., Enami, Shinichi, Hoffmann, M. R.   +2 more
core   +1 more source