Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Metacognición y comprensión lectora: conocimiento y uso de estrategias [PDF]
, 2012 Las investigaciones en relación a la metacognición, y más concretamente, sobre el conocimiento metacognitivo de la tarea de lectura, las correspondientes estrategias y las habilidades que requieren, han puesto de manifiesto que las dificultades que los ...
Arias-Gundín, Olga +2 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Reading strategies of primary school pupils in the Czech Republic [PDF]
Pedagogická Orientace, 2010 This article focuses on reading with comprehension – an activity of the readerwhich is seen as an interaction between the author and the recipient. In order tounderstand a text better, a reader may employ various techniques and strategies.
Veronika Najvarová
doaj
Developing reading comprehension for children with Autism Spectrum Disorder through concrete representations : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Educational Psychology at Massey University, Albany, New Zealand [PDF]
, 2016 The ability to comprehend written text is an essential skill for all students, leading to their increased engagement at school, and the development of communication and cognitive skills.
Serci, Amanda
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
On the Relationship between Metacognitive Reading Strategies, Reading Self-Efficacy, and L2 Reading Comprehension [PDF]
Journal of English Language Teaching and Learning, 2018 The present study was conducted to investigate the relationship between metacognitive reading strategies, reading self-efficacy, and reading comprehension of Iranian EFL learners. The participants were 119 Iranian B.A and M.A students majoring in English
Abbas Ali Zarei
doaj
THE EFFECTIVENESS OF COLLABORATIVE STRATEGIC READING (CSR) TO TEACH CONTENT AREA READING COMPREHENSION VIEWED FROM STUDENTS’ INTELLIGENCE [PDF]
, 2012 This research aims at revealing: (1) whether or not Collaborative Strategic Reading (CSR) strategy is more effective than lecturing strategy in teaching content area reading comprehension; (2) whether the students who have high intelligence have ...
, Ngadiso +2 more
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source