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Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion. [PDF]
J Gen Virol, 2017 Henderson DM +5 more
europepmc +1 more source
Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions. [PDF]
J Clin Microbiol, 2018 Davenport KA +4 more
europepmc +1 more source
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Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis
Neurological Sciences, 2022Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases.
Yashan Wang +7 more
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Movement Disorders, 2022
AbstractBackgroundAggregation of α‐synuclein (oligomeric α‐syn) has been considered as the pathological hallmark of Parkinson's disease (PD) and multiple system atrophy (MSA). Studies showed oligomeric α‐syn/total α‐syn ratio was increased in the saliva of patients with PD, suggesting that seeding activity of salivary oligomeric α‐syn may be a novel ...
Li Zhu, Jianwen Deng
exaly +3 more sources
AbstractBackgroundAggregation of α‐synuclein (oligomeric α‐syn) has been considered as the pathological hallmark of Parkinson's disease (PD) and multiple system atrophy (MSA). Studies showed oligomeric α‐syn/total α‐syn ratio was increased in the saliva of patients with PD, suggesting that seeding activity of salivary oligomeric α‐syn may be a novel ...
Li Zhu, Jianwen Deng
exaly +3 more sources
Real-Time Quaking-Induced Conversion for Diagnosis of Prion Disease
2017Sporadic human prion diseases are defined on the basis of clinical features, with periodic sharp discharge (PSD) on electroencephalograms (EEG), a positive 14-3-3 protein assay of CSF samples, and abnormal signals on cerebral cortex on diffusion-weighted (DWI) MR images.
Katsuya, Satoh +2 more
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Methods in Molecular Biology, 2018 A characteristic feature of transmissible spongiform encephalopathies (TSE) is the progressive accumulation of protein aggregates in the brain in a self-propagation manner. Based on this mechanism, in vitro protein amplification systems (such as real-time quaking-induced conversion (RT-QuIC)) for the detection of misfolded prion protein scrapie (PrPres)
Matthias Schmitz +2 more
exaly +5 more sources
Prion diseases, a group of fatal neurodegenerative disorders, present significant diagnostic challenges due to their subtle clinical manifestations, which often mimic those of other treatable neurological conditions. This diagnostic ambiguity underscores the necessity for reliable and specific diagnostic tools.
Tuane Cristine R G, Vieira +1 more
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Tuane Cristine R G, Vieira +1 more
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