Results 121 to 130 of about 10,380 (154)

Detection and partial discrimination of atypical and classical bovine spongiform encephalopathies in cattle and primates using real-time quaking-induced conversion assay.

, 2017
The transmission of classical bovine spongiform encephalopathy (C-BSE) through contaminated meat product consumption is responsible for variant Creutzfeldt-Jakob disease (vCJD) in humans.
Etienne Levavasseur (94459), Privat, Nicolas, Baron, Thierry, Nicolas Privat, Audrey Culeux (3775615), Seilhean, Danielle, Grznarova, Katarina, Audrey Culeux, Danielle Seilhean, Thierry Baron, Benoit Flan (3775609), Stéphane Haïk (3775606), Véronique Sazdovitch, Steve Simoneau (34280), Emmanuel Comoy, Steve Simoneau, Véronique Sazdovitch (94465), Levavasseur, Etienne, Sazdovitch, Véronique, Katarina Grznarova (3775603), Etienne Levavasseur, Anne-Gaëlle Biacabe, Katarina Grznarova, Thierry Baron (66292), Simoneau, Steve, Nicolas Privat (94463), Haïk, Stéphane, Emmanuel Comoy (577496), Stéphane Haïk, Danielle Seilhean (375896), Anne-Gaëlle Biacabe (3775612), Comoy, Emmanuel, Benoit Flan, Culeux, Audrey, Biacabe, Anne-Gaëlle, Flan, Benoit   +35 more
core   +1 more source

Seeding activity of skin misfolded tau as a biomarker for tauopathies

Molecular Neurodegeneration
Background Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in the brain, leading to prion-like aggregation and propagation.
Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou   +11 more
doaj   +1 more source

Use of bovine recombinant prion protein and real-time quaking-induced conversion to detect cattle transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-Type bovine spongiform encephalopathy.

, 2017
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc).
Justin J. Greenlee (159291), Soyoun Hwang, Justin J Greenlee, Eric M Nicholson, Soyoun Hwang (775330), Eric M. Nicholson (159301)   +5 more
core   +1 more source

Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces

mSphere
Prion diseases are untreatable fatal transmissible neurodegenerative diseases that affect a wide range of mammals, including humans, and are caused by PrPSc, the infectious self-templating conformation of the host-encoded protein, PrPC.
Sara M. Simmons, Vivianne L. Payne, Jay G. Hrdlicka, Jack Taylor, Peter A. Larsen, Tiffany M. Wolf, Marc D. Schwabenlander, Qi Yuan, Jason C. Bartz   +8 more
doaj   +1 more source

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson's Disease. [PDF]

Front Aging Neurosci, 2022
Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP.   +7 more
europepmc   +1 more source

Chronic wasting disease detection in the lymph nodes of free-ranging cervids by real time quaking-induced conversion

, 2014
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of deer, elk and moose, is the only prion disease affecting free-ranging animals.
Galeota, Judith, Gray, Shawn, Carver, Scott, Bunting, Elizabeth, Haley, Nicholas J., Davenport, Kristen A., Dubovos, Tracy, Hoon-Hanks, Laura, LeVan, Ivy, Trindle, Bruce, Henderson, Davin M., Hoover, Edward A., Shelton, Paul   +12 more
core  

Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination

Microbiology Spectrum
Mammalian prion diseases are fatal neurodegenerative disorders caused by the conformational conversion of the host-encoded prion protein (PrP) into a pathogenic, misfolded isoform, known as PrPSc.
A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin   +8 more
doaj   +1 more source

Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

BMC Neurology
Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging.
Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh   +3 more
doaj   +1 more source

Real-Time Quaking-Induced Conversion Detection of PrP^Sc in Fecal Samples From Chronic Wasting Disease Infected White-Tailed Deer Using Bank Vole Substrate. [PDF]

Front Vet Sci, 2021
Hwang S, Greenlee JJ, Nicholson EM.
europepmc   +1 more source

A Real Time Quaking Induced Conversion (RT-QuIC) Assay for Detection of Misfolded Insulin Protein

Abstract Protein misfolding plays a critical role in aging and disease, yet the involvement of specific proteins in metabolic dysfunction is still poorly understood. Here, we report studies on the development of a Real-time Quaking-Induced Conversion (RT-QuIC) assay to detect misfolded insulin, a peptide hormone required for blood ...
Jessica M. Alderiso, Rafael Hernandez LaTorre, Trisha M. Cox, Matthew G. DiGiovanni, Keileigh Fulbright, Brenda F. Canine   +5 more
openaire   +1 more source