Results 111 to 120 of about 4,479 (143)

Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces

mSphere
Prion diseases are untreatable fatal transmissible neurodegenerative diseases that affect a wide range of mammals, including humans, and are caused by PrPSc, the infectious self-templating conformation of the host-encoded protein, PrPC.
Sara M. Simmons, Vivianne L. Payne, Jay G. Hrdlicka, Jack Taylor, Peter A. Larsen, Tiffany M. Wolf, Marc D. Schwabenlander, Qi Yuan, Jason C. Bartz   +8 more
doaj   +1 more source

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson's Disease. [PDF]

Front Aging Neurosci, 2022
Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP.   +7 more
europepmc   +1 more source

Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129 [PDF]

, 2017
Brandner, S, Campbell, T, Collinge, J, Golestani, F, Jager, HR, Jaunmuktane, Z, Joiner, S, Mead, S, Mok, T, Morgan, C, Rudge, P, Wadsworth, JDF, Wakerley, B   +12 more
core   +1 more source

Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination

Microbiology Spectrum
Mammalian prion diseases are fatal neurodegenerative disorders caused by the conformational conversion of the host-encoded prion protein (PrP) into a pathogenic, misfolded isoform, known as PrPSc.
A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin   +8 more
doaj   +1 more source

Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

BMC Neurology
Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging.
Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh   +3 more
doaj   +1 more source

Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan. [PDF]

J Vet Med Sci, 2021
Suzuki A, Sawada K, Erdenebat T, Yamasaki T, Tobiume M, Suga K, Horiuchi M.   +6 more
europepmc   +1 more source

Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (\u3ci\u3eCervus elaphus nelsoni\u3c/i\u3e) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study [PDF]

, 2017
Prion diseases are transmissible spongiform encephalopathies (TSEs) characterized by fatal, progressive neurologic diseases with prolonged incubation periods and an accumulation of infectious misfolded prion proteins.
Dutta, Somak, Halbur, Patrick, Kanthasamy, Anumantha G., Kondru, Naveen, Lehmkuhl, Aaron, Main, Rodger, Manne, Sireesha, Nichols, Tracy, Thomsen, Bruce   +8 more
core   +1 more source

Real-Time Quaking-Induced Conversion Detection of PrP^Sc in Fecal Samples From Chronic Wasting Disease Infected White-Tailed Deer Using Bank Vole Substrate. [PDF]

Front Vet Sci, 2021
Hwang S, Greenlee JJ, Nicholson EM.
europepmc   +1 more source

Detection by real-time quaking-induced conversion (RT-QuIC), ELISA, and IHC of chronic wasting disease prion in lymph nodes from Pennsylvania white-tailed deer with specific PRNP genotypes. [PDF]

J Vet Diagn Invest, 2021
Tewari D, Steward D, Fasnacht M, Livengood J.   +3 more
europepmc   +1 more source

α-Synuclein Real-Time Quaking-Induced Conversion Assay as a Biomarker for Parkinson's Disease: Clinical Implications and Perspectives. [PDF]

J Clin Neurol
Yu JK, Lee YK, Yea DA, Kim YE.
europepmc   +1 more source