Results 111 to 120 of about 10,380 (154)

Diagnosis of human prion disease using real-time quaking-induced conversion testing of olfactory mucosa and cerebrospinal fluid samples

, 2017
Importance: Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguishing treatable from untreatable rapidly progressive dementias and for future therapeutic trials.
Imperiale, Daniele, Cattaruzza, Tatiana, SACCHETTO, Luca, FABRIZI, Gian Maria, Tiple, Dorina, CAPALDI, Stefano, Caughey, Byron, Poleggi, Anna, FIORINI, Michele, Ladogana, Anna, Orrù, Christina, Tonoli, Giovanni, Triva, Giorgio, Cagnin, Annachiara, ZANUSSO, Gianluigi, Castriciano, Santina, MONACO, Salvatore, Marchioni, Daniele, Pocchiari, Maurizio, Colaizzo, Elisa, Hughson, Andrew G, FERRARI, Sergio, TESTI, Silvia, Groveman, Bradley R, BONGIANNI, Matilde, Vaianella, Luana   +25 more
core   +3 more sources

Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay

Acta Neuropathologica Communications
Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing
Remarh Bsoul, Oskar H. McWilliam, Gunhild Waldemar, Steen G. Hasselbalch, Anja H. Simonsen, Christian von Buchwald, Magne Bech, Clara H. Pinborg, Christian K. Pedersen, Sara O. Baungaard, José Lombardía, Patrick Ejlerskov, Matilde Bongianni, Erika Bronzato, Gianluigi Zanusso, Kristian S. Frederiksen, Eva L. Lund, Aušrinė Areškevičiūtė   +17 more
doaj   +1 more source

Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein

YAKUGAKU ZASSHI, 2019
Pathological α-synuclein (αSyn) has been shown to retain the ability to propagate as prions in humans and animals. However, the molecular basis underlying the prion-like properties of αSyn remains poorly understood. We examined whether brain tissues from cases of dementia with Lewy bodies (DLB), which contain serine 129 (Ser129)-phosphorylated ...
openaire   +3 more sources

Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time-Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell Screening.

, 2017
Prion propagation is mediated by the structural alteration of normal prion protein (PrPC) to generate pathogenic prion protein (PrPSc). To date, compounds for the inhibition of prion propagation have mainly been screened using PrPSc-infected cells.
Yeong Seon Lee, Su Yeon Kim, Myung Koo Lee, Sol Moe Lee, Seong Soo A An, Jae Wook Hyeon, Jeongmin Lee   +6 more
core   +1 more source

Prion Seeding Activity in Plant Tissues Detected by RT-QuIC

Pathogens
Prion diseases such as scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) affect domesticated and wild herbivorous mammals. Animals afflicted with CWD, the transmissible spongiform encephalopathy of cervids (deer, elk, and
Kate Burgener, Stuart Siegfried Lichtenberg, Daniel P. Walsh, Heather N. Inzalaco, Aaron Lomax, Joel A. Pedersen   +5 more
doaj   +1 more source

Frequency conversion based on three-wave parametric solitons [PDF]

, 2010
Parametric three-wave mixing in quadratic nonlinear crystals provides a versatile means of achieving widely tunable frequency conversion of laser light, thus permitting a substantial extension of the wavelength coverage of laser sources across broad ...
Degasperis, Antonio, A. DE GASPERIS, de Angelis, Costantino, Wabnitz, Stefan, DE ANGELIS C, Lombardo, Sara, S. LOMBARDO, CONFORTI M, DE GASPERIS, Antonio, Baronio, Fabio, Matteo Conforti, BARONIO F, Stefan Wabnitz, Sara Lombardo, Costantino De, Conforti, Matteo, Fabio Baronio, Antonio Degasperis   +17 more
core   +1 more source

Real-time quaking-induced conversion assays for prions: Applying a sensitive but imperfect test in clinical practice. [PDF]

Eur J Neurol, 2023
Jones SM, Lazar EB, Porter AL, Prusinski CC, Brier MR, Bucelli RC, Day GS.   +6 more
europepmc   +1 more source

Conformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion

, 2014
The phenomenon of prion strains with distinct biological characteristics has been hypothesized to be involved in the structural diversity of abnormal prion protein (PrPSc).
Satoh, Katsuya, Nishida, Noriyuki, Ishibashi, Daisuke, Atarashi, Ryuichiro, Nakagaki, Takehiro, Sano, Kazunori   +5 more
core   +1 more source

Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies

Acta Neuropathologica Communications
We have evaluated the diagnostic potential of the seeding amplification assay (SAA) in detecting α-synuclein seeding activity in postmortem brain and cerebrospinal fluid (CSF) samples from patients with primary and co-pathology α-synucleinopathies ...
Soňa Baranová, Radoslav Matěj, Jakub Soukup, Petr Dušek, Karel Holada   +4 more
doaj   +1 more source

Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay.

, 2014
Real-time quaking-induced conversion (RT-QuIC), a highly specific and sensitive assay able to detect low levels of the disease-inducing isoform of the prion protein (PrP(d)) in brain tissue biopsies and cerebral spinal fluid, has great potential to ...
Michael Coulthart (505621), Michael Carpenter (505622), Kristen M Avery, Angela Sloan, Keding Cheng (380909), Angela Sloan (380916), Keding Cheng, J David Knox, Michael Coulthart, Michael Carpenter, J. David Knox (414396), Kristen M. Avery (505620)   +11 more
core   +1 more source