Results 111 to 120 of about 20,909,028 (154)

Prion Seeding Activity in Plant Tissues Detected by RT-QuIC

Pathogens
Prion diseases such as scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) affect domesticated and wild herbivorous mammals. Animals afflicted with CWD, the transmissible spongiform encephalopathy of cervids (deer, elk, and
Kate Burgener, Stuart Siegfried Lichtenberg, Daniel P. Walsh, Heather N. Inzalaco, Aaron Lomax, Joel A. Pedersen   +5 more
doaj   +1 more source

Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies

Acta Neuropathologica Communications
We have evaluated the diagnostic potential of the seeding amplification assay (SAA) in detecting α-synuclein seeding activity in postmortem brain and cerebrospinal fluid (CSF) samples from patients with primary and co-pathology α-synucleinopathies ...
Soňa Baranová, Radoslav Matěj, Jakub Soukup, Petr Dušek, Karel Holada   +4 more
doaj   +1 more source

Prevalence of Lewy body pathology and phenotypic associations in patients with mild cognitive impairment: Evidence from the Interceptor study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Clinical effects and prevalence of Lewy body (LB) pathology in patients with mild cognitive impairment (MCI) remain poorly understood. METHODS We assessed LB pathology in 339 patients with MCI from the Italian multicenter Interceptor cohort ...
Simone Baiardi, Serena Caldera, Sabina Capellari, Franco Magliocchetti, Angela Mammana, Corrado Zenesini, Stefano Cappa, Naike Caraglia, Maria Cotelli, Camillo Marra, Francesca Miraglia, Daniela Perani, Alberto Redolfi, Patrizia Spadin, Fabrizio Tagliavini, Nicola Vanacore, Fabrizio Vecchio, Paolo Maria Rossini, Piero Parchi   +18 more
doaj   +1 more source

Prion Disorders Update: An Indian Perspective

Annals of Movement Disorders
Prion disorders are rare neurodegenerative disorders resulting from proteinaceous infectious particles and are universally fatal. It can be sporadic, genetic, or acquired.
Taallapalli Ashok Vardhan Reddy, Sindhu Toomukuntla, Anshuman Pradhan, Niraj Kumar   +3 more
doaj   +1 more source

Towards an HLA Run-time Infrastructure with Hard Real-time Capabilities [PDF]

, 2010
Our work takes place in the context of the HLA standard and its application in real-time systems context. The HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Siron, Pierre, Chaudron, Jean-Baptiste   +2 more
core  

Seeding activity of skin misfolded tau as a biomarker for tauopathies

Molecular Neurodegeneration
Background Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in the brain, leading to prion-like aggregation and propagation.
Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou   +11 more
doaj   +1 more source

HLA high performance and real-time simulation studies with CERTI [PDF]

, 2011
Our work takes place in the context of the HLA standard and its application in real-time systems context. Indeed, current HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Noulard, Eric, Chaudron, Jean-Baptiste, Siron, Pierre   +3 more
core  

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson's Disease. [PDF]

Front Aging Neurosci, 2022
Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP.   +7 more
europepmc   +1 more source

Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces

mSphere
Prion diseases are untreatable fatal transmissible neurodegenerative diseases that affect a wide range of mammals, including humans, and are caused by PrPSc, the infectious self-templating conformation of the host-encoded protein, PrPC.
Sara M. Simmons, Vivianne L. Payne, Jay G. Hrdlicka, Jack Taylor, Peter A. Larsen, Tiffany M. Wolf, Marc D. Schwabenlander, Qi Yuan, Jason C. Bartz   +8 more
doaj   +1 more source

Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

BMC Neurology
Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging.
Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh   +3 more
doaj   +1 more source