Results 101 to 110 of about 2,160 (134)

Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

BMC Neurology
Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging.
Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh   +3 more
doaj   +1 more source

Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination

Microbiology Spectrum
Mammalian prion diseases are fatal neurodegenerative disorders caused by the conformational conversion of the host-encoded prion protein (PrP) into a pathogenic, misfolded isoform, known as PrPSc.
A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin   +8 more
doaj   +1 more source

A Real Time Quaking Induced Conversion (RT-QuIC) Assay for Detection of Misfolded Insulin Protein

Abstract Protein misfolding plays a critical role in aging and disease, yet the involvement of specific proteins in metabolic dysfunction is still poorly understood. Here, we report studies on the development of a Real-time Quaking-Induced Conversion (RT-QuIC) assay to detect misfolded insulin, a peptide hormone required for blood ...
Jessica M. Alderiso, Rafael Hernandez LaTorre, Trisha M. Cox, Matthew G. DiGiovanni, Keileigh Fulbright, Brenda F. Canine   +5 more
openaire   +1 more source

Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies. [PDF]

Neurology, 2021
Rossi M, Baiardi S, Teunissen CE, Quadalti C, van de Beek M, Mammana A, Stanzani-Maserati M, Van der Flier WM, Sambati L, Zenesini C, Caughey B, Capellari S, Lemstra AW, Parchi P.   +13 more
europepmc   +1 more source

Real-Time Quaking-Induced Conversion Detection of PrP^Sc in Fecal Samples From Chronic Wasting Disease Infected White-Tailed Deer Using Bank Vole Substrate. [PDF]

Front Vet Sci, 2021
Hwang S, Greenlee JJ, Nicholson EM.
europepmc   +1 more source

Detection by real-time quaking-induced conversion (RT-QuIC), ELISA, and IHC of chronic wasting disease prion in lymph nodes from Pennsylvania white-tailed deer with specific PRNP genotypes. [PDF]

J Vet Diagn Invest, 2021
Tewari D, Steward D, Fasnacht M, Livengood J.   +3 more
europepmc   +1 more source

Real-Time Quaking-Induced Conversion Assay Applied to the Italian Chronic Wasting Disease Monitoring Plan: Comparison of Classical and Innovative Diagnostic Methods. [PDF]

Pathogens
Mazza M, Favole A, Campia V, Iulini B, Nonno R, Ligios C, Pintus D, Peletto S, Casalone C, Corona C, Bozzetta E, Acutis PL.   +11 more
europepmc   +1 more source

Comparison of the detection of the chronic wasting disease prion by real-time quaking-induced conversion (rtQuIC) and silica nanoparticle-rtQuIC (nano-rtQuIC) assays in retropharyngeal lymph nodes of white-tailed deer, mule deer, and Rocky Mountain elk. [PDF]

J Vet Diagn Invest
Ralston BA, Jennings J, Allen SE.
europepmc   +1 more source

Prion Positivity Detected by Real-Time Quaking-Induced Conversion (RT-QuIC) in the Cadaver of an Elderly Woman Subjected to Forensic Autopsy. [PDF]

Cureus
Nakagaki T, Hayashi T, Kaneko M, Akagi A, Furusato B, Iwasaki Y, Satoh K, Ikematsu K, Nishida N.   +8 more
europepmc   +1 more source

Inter-laboratory comparison of real-time quaking-induced conversion (RT-QuIC) for the detection of chronic wasting disease prions in white-tailed deer retropharyngeal lymph nodes. [PDF]

J Vet Diagn Invest
Darish JR, Kaganer AW, Hanley BJ, Schuler KL, Schwabenlander MD, Wolf TM, Ahmed MS, Rowden GR, Larsen PA, Kobashigawa E, Tewari D, Lichtenberg S, Pedersen JA, Zhang S, Sreevatsan S.   +14 more
europepmc   +1 more source