Results 91 to 100 of about 2,160 (134)

Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay

Acta Neuropathologica Communications
Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing
Remarh Bsoul, Oskar H. McWilliam, Gunhild Waldemar, Steen G. Hasselbalch, Anja H. Simonsen, Christian von Buchwald, Magne Bech, Clara H. Pinborg, Christian K. Pedersen, Sara O. Baungaard, José Lombardía, Patrick Ejlerskov, Matilde Bongianni, Erika Bronzato, Gianluigi Zanusso, Kristian S. Frederiksen, Eva L. Lund, Aušrinė Areškevičiūtė   +17 more
doaj   +1 more source

Gerstmann-Sträussler- Scheinker Disease: A Case Report

Journal of the Korean Society of Radiology, 2023
Gerstmann-Sträussler-Scheinker (GSS) disease is a rare hereditary prion disease which is clinically characterized by a progressive cerebellar ataxia followed by cognitive impairment.
Minji Shin, Donghyun Kim, Young Jin Heo, Jin Wook Baek, Suyoung Yun, Hae Woong Jeong   +5 more
doaj   +1 more source

Prion Seeding Activity in Plant Tissues Detected by RT-QuIC

Pathogens
Prion diseases such as scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) affect domesticated and wild herbivorous mammals. Animals afflicted with CWD, the transmissible spongiform encephalopathy of cervids (deer, elk, and
Kate Burgener, Stuart Siegfried Lichtenberg, Daniel P. Walsh, Heather N. Inzalaco, Aaron Lomax, Joel A. Pedersen   +5 more
doaj   +1 more source

Real-time quaking-induced conversion assays for prions: Applying a sensitive but imperfect test in clinical practice. [PDF]

Eur J Neurol, 2023
Jones SM, Lazar EB, Porter AL, Prusinski CC, Brier MR, Bucelli RC, Day GS.   +6 more
europepmc   +1 more source

Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies

Acta Neuropathologica Communications
We have evaluated the diagnostic potential of the seeding amplification assay (SAA) in detecting α-synuclein seeding activity in postmortem brain and cerebrospinal fluid (CSF) samples from patients with primary and co-pathology α-synucleinopathies ...
Soňa Baranová, Radoslav Matěj, Jakub Soukup, Petr Dušek, Karel Holada   +4 more
doaj   +1 more source

Prevalence of Lewy body pathology and phenotypic associations in patients with mild cognitive impairment: Evidence from the Interceptor study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Clinical effects and prevalence of Lewy body (LB) pathology in patients with mild cognitive impairment (MCI) remain poorly understood. METHODS We assessed LB pathology in 339 patients with MCI from the Italian multicenter Interceptor cohort ...
Simone Baiardi, Serena Caldera, Sabina Capellari, Franco Magliocchetti, Angela Mammana, Corrado Zenesini, Stefano Cappa, Naike Caraglia, Maria Cotelli, Camillo Marra, Francesca Miraglia, Daniela Perani, Alberto Redolfi, Patrizia Spadin, Fabrizio Tagliavini, Nicola Vanacore, Fabrizio Vecchio, Paolo Maria Rossini, Piero Parchi   +18 more
doaj   +1 more source

Seeding activity of skin misfolded tau as a biomarker for tauopathies

Molecular Neurodegeneration
Background Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in the brain, leading to prion-like aggregation and propagation.
Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou   +11 more
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson's Disease. [PDF]

Front Aging Neurosci, 2022
Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP.   +7 more
europepmc   +1 more source

Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces

mSphere
Prion diseases are untreatable fatal transmissible neurodegenerative diseases that affect a wide range of mammals, including humans, and are caused by PrPSc, the infectious self-templating conformation of the host-encoded protein, PrPC.
Sara M. Simmons, Vivianne L. Payne, Jay G. Hrdlicka, Jack Taylor, Peter A. Larsen, Tiffany M. Wolf, Marc D. Schwabenlander, Qi Yuan, Jason C. Bartz   +8 more
doaj   +1 more source