Results 81 to 90 of about 2,160 (134)

Enhanced prion detection in biological samples by magnetic particle extraction and real-time quaking-induced conversion

Journal of General Virology, 2016
Prions have been demonstrated in body fluids and excreta using bioassay, but at levels too low for detection by conventional direct-detection assays. More rapid and sensitive detection of prions in these clinically accessible specimens would be valuable for diagnosis and investigations of transmission, environmental impact, and interventions.
Nathaniel D, Denkers, Davin M, Henderson, Candace K, Mathiason, Edward A, Hoover   +3 more
openaire   +2 more sources

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion

Journal of General Virology, 2016
Real-time quaking-induced conversion (RT-QuIC) is a rapid, specific and highly sensitive prion seeding activity detection assay that uses recombinant prion protein (rPrPSen) to detect subinfectious levels of the abnormal isoforms of the prion protein (PrPSc). Although RT-QuIC has been successfully used to detect PrPSc in various tissues from humans and
Rohana P, Dassanayake, Christina D, Orrú, Andrew G, Hughson, Byron, Caughey, Telmo, Graça, Dongyue, Zhuang, Sally A, Madsen-Bouterse, Donald P, Knowles, David A, Schneider   +8 more
openaire   +2 more sources

Creutzfeldt-Jakob Disease – A Series of Four Clinical Cases

Acta Medica Bulgarica
Creutzfeldt-Jakob Disease (CJD) is a rare, progressive, and fatal degenerative brain disorder caused by prion proteins. The diagnosis of the disease is based on established criteria and biomarkers – cerebrospinal fluid analysis, real-time quaking induced
Karameshev A., Yoshinov B., Dimova P., Tanova R., Penkov M., Kochmalarski B., Mihaylova K., Stoilova D., Shotekov P.   +8 more
doaj   +1 more source

Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia

Biomédica: revista del Instituto Nacional de Salud
Creutzfeldt-Jakob disease is a rare neurodegenerative disease caused by prions. We present the case of a woman in the seventh decade of life with rapidly progressive dementia and myoclonus.
Jairo Lizarazo, Aixa Xiomara Vargas, Rafael Olarte, David Andrés Lizarazo   +3 more
doaj   +1 more source

Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Cerebral Cortical Encephalitis: A Comparative Study With Antibody‐Negative and Non‐MOG Antibody‐Positive Cortical Encephalitis in Chinese Adults

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
MOG antibody‐associated cortical encephalitis (MOG‐CCE) presents a distinct clinical phenotype characterized by seizure‐dominant onset, unilateral cortical lesions, and favorable immunotherapy response, highlighting the diagnostic and prognostic value of antibody profiling in autoimmune cortical encephalitis.
Qing Yin, Binhong Han, Kai Su, Weiqi Dai, Jing Wu, Li Yang, Yuwei Dai, Dan Wang   +7 more
wiley   +1 more source

Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis

Annals of Neurology, Volume 99, Issue 6, Page 1466-1467, June 2026.
Kate Durbano, Marie Belley, Delphine Leclercq, Louis Cousyn   +3 more
wiley   +1 more source

Opportunities for the U.S. Geological Survey's National Seismic Hazard Model to Improve Seismic Risk Assessment of Critical Infrastructure

Earthquake Spectra, Volume 42, Issue 2, May 2026.
As fragility and risk modeling techniques and computational capabilities evolve, complemented by moving toward more routine and systematic seismic risk assessment of all buildings and critical infrastructure, the authors pose a few critical questions to investigate how the U.S. Geological Survey (USGS) National Seismic Hazard Models (NSHMs) can be used
Kishor S. Jaiswal, N. Simon Kwong
wiley   +1 more source

Moose indifferent to canopy loss from forest disturbance by bark beetles

The Journal of Wildlife Management, Volume 90, Issue 4, May 2026.
Moose showed strikingly similar patterns of habitat selection before and after widespread forest disturbance following an infestation of bark beetles. Our findings indicate that beetle‐kill does not appreciably alter habitat quality for moose and highlight the importance of riparian areas in sustaining moose as they contend with changing forests ...
Alexander B. May, Rebecca L. Levine, Lee Knox, Corey Class, Matthew J. Kauffman, Kevin L. Monteith   +5 more
wiley   +1 more source

Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site

Prion
Chronic wasting disease (CWD) is a contagious prion disorder affecting cervids such as deer, elk, caribou, and moose, causing progressive and severe neurological degeneration followed by eventual death.
Madeline K. Grunklee, Stuart S. Lichtenberg, Nicole A. Lurndahl, Marc D. Schwabenlander, Diana L. Karwan, E. Anu Li, Jason C. Bartz, Qi Yuan, Peter A. Larsen, Tiffany M. Wolf   +9 more
doaj   +1 more source