Results 81 to 90 of about 20,909,028 (154)

Cerebrospinal fluid α‐synuclein and Aβ42 link with default mode and salience networks connectivity in dementia with Lewy bodies

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include α‐synuclein, amyloid‐beta 42 (Aβ42), and tau protein aggregation. While cerebrospinal fluid (CSF) biomarkers provide in vivo insight into these pathologies,
Vincent Gabriel, Elena Chabran, Marion Sourty, Benjamin Cretin, Nathalie Philippi, Candice Muller, Pierre Anthony, Catherine Demuynck, Paulo Loureiro de Sousa, Anne Botzung, Léa Sanna, Olivier Bousiges, Frédéric Blanc   +12 more
wiley   +1 more source

A Real-time Service Oriented Infrastructure [PDF]

, 2010
The advancements in distributed computing have driven the emergence of service-based infrastructures that allow for on-demand provision of ICT assets. Taking into consideration the complexity of distributed environments, significant challenges exist in ...
Michael Boniface, Voith, T, Soren Berger, Cucinotta, T, Tommaso Cucinott, Dimosthenis Kyriazis, Voith, Thomas, Eduardo Oliveros, Oberle, K, Andreas Menychtas, Karsten Oberle, Kyriazis, D, Kyriazis, Dimosthenis, Menychtas, Andreas, Oliveros, Eduardo, Thomas Voith, Oberle, Karsten, Menychtas, A, Tommaso Cucinotta, Berger, Sören, George Kousiouris, Oliveros, E, Kousiouris, George, Berger, S, Boniface, Mike, Kousiouris, G, Cucinotta, Tommaso   +26 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Detection of Chronic Wasting Disease in the Lymph Nodes of Free-Ranging Cervids by Real-Time Quaking-Induced Conversion [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of deer, elk, and moose, is the only prion disease affecting free-ranging animals. Since the disease was first identified in northern Colorado and southern Wyoming in 1967, new epidemic foci of the disease have been identified in 20 additional states, as well as
Nicholas J, Haley, Scott, Carver, Laura L, Hoon-Hanks, Davin M, Henderson, Kristen A, Davenport, Elizabeth, Bunting, Shawn, Gray, Bruce, Trindle, Judith, Galeota, Ivy, LeVan, Tracy, Dubovos, Paul, Shelton, Edward A, Hoover   +12 more
openaire   +2 more sources

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Sensitive and specific detection of sporadic Creutzfeldt–Jakob disease brain prion protein using real-time quaking-induced conversion

, 2012
Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time ...
Nigel E. J. Appleford, Byron Caughey, Gary Mallinson, James W. Ironside, Alison J. E. Green, Richard S. Knight, Jason M. Wilham, Robert G. Will, Mark W. Head, Christina D. Orrú, Alexander H. Peden, Lynne I. McGuire   +11 more
core   +1 more source

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

Translational Neurodegeneration, 2023
α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies ...
Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr   +9 more
doaj   +1 more source

Creating Flood Disasters: Environmental Memory and Adaptation in Aotearoa New Zealand

Kōtuitui: New Zealand Journal of Social Sciences Online, Volume 21, Issue 2, June 2026.
This article explores three questions. First, why does New Zealand have widespread flooding hazards? Second, why are these persistent, with little seemingly learned from the memory of earlier events? And third, beyond reiterating conventional solutions, what examples of alternatives or adaptations are being developed in different places?
Eric Pawson
wiley   +1 more source

Aerial and Space‐Borne Seismology on Venus: Viability and Design Implications for Future Missions

Earth and Space Science, Volume 13, Issue 6, June 2026.
Abstract Venus' evolution remains a mystery because of the lack of in situ geophysical data to constrain its interior structure. Recently‐selected planetary missions VERITAS (NASA), DAVINCI+ (NASA), and EnVision (ESA) will investigate the planet's interior, surface, and atmospheric chemistry.
Quentin Brissaud, Chenxi Kong, Marouchka Froment, John Wilding, Anna J. P. Gülcher, Jennifer M. Jackson, Iris van Zelst, Raphaël F. Garci, Celine Marie Solberg, Sven Peter Näsholm   +9 more
wiley   +1 more source

Determination of prion proteins in the diagnosis of Creutzfeldt-Jakob disease using RT-QuIC: A case report from northeastern Colombia

Biomédica: revista del Instituto Nacional de Salud
Creutzfeldt-Jakob disease is a rare neurodegenerative disease caused by prions. We present the case of a woman in the seventh decade of life with rapidly progressive dementia and myoclonus.
Jairo Lizarazo, Aixa Xiomara Vargas, Rafael Olarte, David Andrés Lizarazo   +3 more
doaj   +1 more source