Results 81 to 90 of about 4,479 (143)

Scalable assay to identify inhibitors of prion‐like propagation of protein misfolding as potential therapeutics for neurodegeneration

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Protein misfolding is linked to many neurodegenerative diseases. In some cases, misfolding can propagate through a prion‐like mechanism whereby natively folded molecules are converted into more copies of the misfolded isoform. Prion‐like propagation of misfolding is an attractive therapeutic target, but difficulties with assaying conversion ...
Abhishek Narayan, Krishna Neupane, Michael T. Woodside   +2 more
wiley   +1 more source

quicR: An R library for streamlined data handling of real-time quaking induced conversion assays

SoftwareX
Real-time quaking induced conversion (RT-QuIC) has become a valuable diagnostic tool for protein misfolding disorders such as Creutzfeldt–Jakob disease and Parkinson’s disease.
Gage R. Rowden, Peter A. Larsen
doaj   +1 more source

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

Translational Neurodegeneration, 2023
α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies ...
Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr   +9 more
doaj   +1 more source

Thermally Activated Static Friction Can Explain Earthquake Interactions

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 4, April 2026.
Abstract Unlike meteorological hazards, tectonic earthquakes remain hardly predictable, reinforcing their deadly character. This relates to an out‐of‐equilibrium, intermittent dynamic associated with a strong time asymmetry, with few and non‐systematic foreshocks sometimes preceding large earthquakes, while aftershocks are ubiquitous and have been ...
J. Weiss, D. Marsan, P. Thiraux
wiley   +1 more source

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. [PDF]

PLoS Pathogens, 2010
A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required prolonged bioassays in animals.
Jason M Wilham, Christina D Orrú, Richard A Bessen, Ryuichiro Atarashi, Kazunori Sano, Brent Race, Kimberly D Meade-White, Lara M Taubner, Andrew Timmes, Byron Caughey   +9 more
doaj   +1 more source

Prolonged Hypocenter Migration in a Lower‐Crustal Earthquake Swarm in Japan: Positive Feedback Between Heat Influx and Fluid Production

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 4, April 2026.
Abstract The Yamaguchi earthquake swarm in western Japan occurred at unusually deep depths (25–40 km), well below the seismogenic zone, and exhibited prolonged zigzag hypocenter migrations over at least ∼180 days. Seismicity initiated in the southwestern part of the swarm area, followed by systematic migration eastward, northeastward, and northwestward.
Junichi Nakajima, Kazuki Miyazaki, Nobuaki Suenaga, Shintaro Azuma, Shoichi Yoshioka   +4 more
wiley   +1 more source

Investigating the Detectability of Body Wave Phases From Tidal Ice Cracking Events on Titan With the Dragonfly Short‐Period Seismometer

Journal of Geophysical Research: Planets, Volume 131, Issue 4, April 2026.
Abstract Detecting seismic activity on Saturn's icy moon Titan during the Dragonfly mission could provide crucial information on its internal structure. The geological complexity of the moon's surface suggests significant cyclic tidal deformation, likely leading to the fracturing of the ice shell.
L. Delaroque, T. Kawamura, A. Lucas, S. Rodriguez, K. Onodera, H. Shiraishi, R. Yamada, S. Tanaka, M. P. Panning, R. D. Lorenz   +9 more
wiley   +1 more source

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods [PDF]

, 2018
The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases.
Arai Tetsuaki, Hasegawa Masato, Hisanaga Shin-ichi, Murayama Shigeo, Tarutani Airi, 新井 哲明   +5 more
core   +2 more sources

A Novel 3D Semi‐Automated Full Quantification Technique for Detection of Intraneural Phospho‐α‐Synuclein in Skin Biopsies

European Journal of Neurology, Volume 33, Issue 4, April 2026.
A novel semi‐automated 3D immunofluorescence technique enables full volumetric quantification of intraneural phospho‐α‐synuclein load in skin biopsies. It refines conventional visually based signal assessment through a more objective, computer‐assisted procedure and provides burden‐dependent test results important for differential diagnostics.
Sophia Lonczewski, Verian Bader, Louisa Ortmann, Louisa Basner, Markus Stücker, Ralf Gold, Raphael Scherbaum, Eun Hae Kwon, Konstanze F. Winklhofer, Lars Tönges   +9 more
wiley   +1 more source

Creutzfeldt-Jakob Disease – A Series of Four Clinical Cases

Acta Medica Bulgarica
Creutzfeldt-Jakob Disease (CJD) is a rare, progressive, and fatal degenerative brain disorder caused by prion proteins. The diagnosis of the disease is based on established criteria and biomarkers – cerebrospinal fluid analysis, real-time quaking induced
Karameshev A., Yoshinov B., Dimova P., Tanova R., Penkov M., Kochmalarski B., Mihaylova K., Stoilova D., Shotekov P.   +8 more
doaj   +1 more source