Results 61 to 70 of about 20,909,028 (154)

A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion [PDF]

Scientific Reports, 2016
AbstractAccidental transmission of prions during neurosurgery has been reported as a consequence of re-using contaminated surgical instruments. Several decontamination methods have been studied using the 263K-hamster prion; however, no studies have directly evaluated human prions.
Tsuyoshi Mori, Ryuichiro Atarashi, Kana Furukawa, Hanae Takatsuki, Katsuya Satoh, Kazunori Sano, Takehiro Nakagaki, Daisuke Ishibashi, Kazuko Ichimiya, Masahisa Hamada, Takehisa Nakayama, Noriyuki Nishida   +11 more
openaire   +2 more sources

Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay. [PDF]

J Vet Med Sci, 2019
Atypical bovine spongiform encephalopathy (BSE), first identified in 2004, poses a threat due to the potential to spread the disease to cattle and other animals, including humans. Here, we estimated prion titers in various tissues of cattle infected with atypical BSE using a real-time quaking-induced conversion assay that detects amyloid seeding ...
Sawada K, Suzuki A, Yamasaki T, Iwamaru Y, Matsuura Y, Miyazawa K, Masujin K, Atarashi R, Horiuchi M.   +8 more
europepmc   +4 more sources

An Overview of High‐Temperature Superconducting Cables in DC Systems: Unlocking Potential for High‐Voltage DC Networks

High Voltage, EarlyView.
ABSTRACT This paper provides an overview of high‐temperature superconducting (HTS) cables in DC systems, with a focus on their deployment in high‐voltage DC (HVDC) networks. The assessment of HTS cable properties—such as extremely low electrical resistance, high current‐carrying capacity and a compact geometry—and their comparison with those of ...
Mohammad Hossein Mousavi, Hassan Moradi, Kumars Rouzbehi   +2 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Functional memory of drought affects leaf chemical defenses and microbial interactions in aspen

New Phytologist, EarlyView.
Experimental design of the common garden study. Summary Drought is an important driver of tree mortality, but its long‐term impacts on trait expression remain poorly understood. Leaves are a key interface at which trees respond to abiotic stress, and foliar traits such as chemical defenses and microbial communities may play a role in determining post ...
Aubrey M. Hawks, Jaycie C. Fickle, Kelly L. Kerr, Dale L. Forrister, Allison M. Perkins, Efthymia Symeonidi, Madelyn Allen, Cannon Fehrenbach, Hsiao‐Nung Chen, Richard L. Lindroth, William R. L. Anderegg, Talia L. Karasov   +11 more
wiley   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, Volume 13, Issue 49, 3 September 2026.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion

Journal of General Virology, 2015
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving the templated conversion of the normal cellular prion protein (PrP(C)) to a pathogenic misfolded conformation. Templated conversion has been modelled in several in vitro assays, including serial protein misfolding amplification, amyloid ...
Davin M, Henderson, Kristen A, Davenport, Nicholas J, Haley, Nathaniel D, Denkers, Candace K, Mathiason, Edward A, Hoover   +5 more
openaire   +2 more sources

Detection and Discrimination of Classical and Atypical L-Type Bovine Spongiform Encephalopathy by Real-Time Quaking-Induced Conversion [PDF]

Journal of Clinical Microbiology, 2015
ABSTRACTStatutory surveillance of bovine spongiform encephalopathy (BSE) indicates that cattle are susceptible to both classical BSE (C-BSE) and atypical forms of BSE. Atypical forms of BSE appear to be sporadic and thus may never be eradicated. A major challenge for prion surveillance is the lack of sufficiently practical and sensitive tests for ...
Orrú C. D., Favole A., Corona C., Mazza M., Manca M., Groveman B. R., Hughson A. G., Acutis P. L., Caramelli M., ZANUSSO, Gianluigi, Casalone C., Caughey B.   +11 more
openaire   +3 more sources

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Circular RNAs (circRNAs) are stable, stage‐ and tissue‐specific regulators of gene expression warranting their study in abnormal fetal lung development in congenital diaphragmatic hernia (CDH). We present a CDH‐specific circRNA biosignature in the nitrofen rat model (E15/E21) using orthogonal validation with human comparison and discovered conserved ...
Marietta Jank, Arzu Ozturk Aptekmann, Rina Tanaka, Muntahi Mourin, Nolan De Leon, Matthew Kraljevic, Daywin Patel, Wai Hei Tse, Claire McCallum, Richard Wagner, Shana Kahnamoui, Yuichiro Miyake, Athanasios Zovoilis, Takashi Doi, Michael Boettcher, Richard LeDuc, Richard Keijzer   +16 more
wiley   +1 more source

Lumped time-delay compensation scheme for coding synchronization in the nonlinear spectral quantization-based all-optical analog-to-digital conversion [PDF]

, 2013
In this paper, we propose a novel lumped time-delay compensation scheme for the all-optical analog-to-digital conversion based on soliton self-frequency shift and optical interconnection techniques.
Y, Chongxiu, Yu, Chongxiu, Li, Sha, Khang, Zhe, Yuan, Jinhui, Farrell, Gerald, Wang, Tao, Sang, Xinzhu, Kang, Zhe, Wu, Qiang   +9 more
core   +1 more source