Results 61 to 70 of about 2,160 (134)

The HCG11/QKI5 Axis Regulates Endothelial Angiogenic Adaptation During Chronic Cerebral Hypoperfusion

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Chronic cerebral hypoperfusion induces endothelial hypoxic stress. During the early adaptive phase, the HCG11/QKI5 axis acts upstream of HIF‐1α/VEGF signaling to promote compensatory angiogenesis. With prolonged hypoperfusion, this regulatory pathway declines, leading to impaired vascular adaptation.
Xueqiao Jiao, Rui Li, Lulan Li, Xiao Wu, Lu Wang, Fuxia Yang, Fangfang Zhang, Jia Liu, Xunming Ji, Xiuhai Guo   +9 more
wiley   +1 more source

Creutzfeldt-Jakob disease: recent developments [version 1; referees: 2 approved]

F1000Research, 2017
Creutzfeldt-Jakob disease (CJD) is a rare prion disorder that has been the subject of both professional and public interest following the identification of variant CJD as a zoonotic disorder.
Graeme Mackenzie, Robert Will
doaj   +1 more source

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

Translational Neurodegeneration, 2022
Background In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies.
Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente, Michele Fiorini, Erika Bronzato, Stefano Tamburin, Laura Bertolasi, Lorenzo Brozzetti, Maria Paola Cecchini, Gianluigi Gigli, Salvatore Monaco, Paolo Manganotti, Gianluigi Zanusso   +25 more
doaj   +1 more source

Cerebrospinal fluid α‐synuclein and Aβ42 link with default mode and salience networks connectivity in dementia with Lewy bodies

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are neurocognitive disorders characterized by distinct but often overlapping pathological processes. These include α‐synuclein, amyloid‐beta 42 (Aβ42), and tau protein aggregation. While cerebrospinal fluid (CSF) biomarkers provide in vivo insight into these pathologies,
Vincent Gabriel, Elena Chabran, Marion Sourty, Benjamin Cretin, Nathalie Philippi, Candice Muller, Pierre Anthony, Catherine Demuynck, Paulo Loureiro de Sousa, Anne Botzung, Léa Sanna, Olivier Bousiges, Frédéric Blanc   +12 more
wiley   +1 more source

Detection and Discrimination of Classical and Atypical L-Type Bovine Spongiform Encephalopathy by Real-Time Quaking-Induced Conversion [PDF]

Journal of Clinical Microbiology, 2015
ABSTRACTStatutory surveillance of bovine spongiform encephalopathy (BSE) indicates that cattle are susceptible to both classical BSE (C-BSE) and atypical forms of BSE. Atypical forms of BSE appear to be sporadic and thus may never be eradicated. A major challenge for prion surveillance is the lack of sufficiently practical and sensitive tests for ...
Orrú C. D., Favole A., Corona C., Mazza M., Manca M., Groveman B. R., Hughson A. G., Acutis P. L., Caramelli M., ZANUSSO, Gianluigi, Casalone C., Caughey B.   +11 more
openaire   +3 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion. [PDF]

PLoS ONE, 2016
Chronic wasting disease (CWD) is a fatal prion disease of wild and captive cervids in North America. Prions are infectious agents composed of a misfolded version of a host-encoded protein, termed PrPSc.
Yo Ching Cheng, Samia Hannaoui, Theodore R John, Sandor Dudas, Stefanie Czub, Sabine Gilch   +5 more
doaj   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Creating Flood Disasters: Environmental Memory and Adaptation in Aotearoa New Zealand

Kōtuitui: New Zealand Journal of Social Sciences Online, Volume 21, Issue 2, June 2026.
This article explores three questions. First, why does New Zealand have widespread flooding hazards? Second, why are these persistent, with little seemingly learned from the memory of earlier events? And third, beyond reiterating conventional solutions, what examples of alternatives or adaptations are being developed in different places?
Eric Pawson
wiley   +1 more source

Diagnostic value of cerebrospinal fluid tau and real⁃time quaking⁃induced conversion in sporadic Creutzfeldt⁃Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To explore the diagnostic value of cerebrospinal fluid (CSF) biomarkers, total tau protein (t‑tau), phosphorylated tau protein 181 (p‑tau181) and real‑time quaking‑induced conversion (RT ‑QuIC) in sporadic Creutzfeldt‑Jakob disease (sCJD ...
WANG Xiao‑yan, CUI Mei, CHEN Shu‑fen, HUANG Yu‑yuan, ZHAO Zhong, YU Jin‑tai   +5 more
doaj   +1 more source