Results 41 to 50 of about 4,479 (143)

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression [PDF]

, 2018
OBJECTIVES: A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies.
Collinge, J, Heslegrave, AJ, Jackson, GS, Luk, C, Mead, SH, Thompson, AGB, Zetterberg, H   +6 more
core   +1 more source

Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates. [PDF]

Prion, 2020
Suzuki A, Sawada K, Yamasaki T, Denkers ND, Mathiason CK, Hoover EA, Horiuchi M.   +6 more
europepmc   +2 more sources

Early and Pre-Clinical Detection of Prion Seeding Activity in Cerebrospinal Fluid of Goats using Real-Time Quaking-Induced Conversion Assay. [PDF]

Sci Rep, 2019
Favole A, Mazza M, Vallino Costassa E, D'Angelo A, Lombardi G, Marconi P, Crociara P, Berrone E, Gallo M, Palmitessa C, Orrù CD, Caughey B, Acutis PL, Caramelli M, Casalone C, Corona C.   +15 more
europepmc   +3 more sources

Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems [PDF]

, 2014
Dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) can be divided into two subgroups that exhibit distinct clinical and neuropathological features, with the majority represented by a non-plaque-type of dCJD (np-dCJD) and the minority by a ...
Atsushi Kobayashi, Shirou Mohri, Tetsuyuki Kitamoto, Yuichi Matsuura   +3 more
core   +1 more source

Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrPSc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC [PDF]

, 2012
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrPSc) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrPSc propagation involves conversion from its
AH Peden, Alessandra Pani, Andrew G. Hughson, B Caughey, B Caughey, B Chesebro, B Chesebro, B Ghetti, Brent Race, BW Caughey, Byron Caughey, C Korth, C Soto, CD Orru, CD Orru, CD Orru, CE Mays, Christina D. Orrù, CI Lasmezas, DA Kocisko, Declan King, EJ Field, F Wang, G Legname, G Sajnani, Gerald S. Baron, GP Saborio, GS Baron, H Diringer, H Diringer, J Castilla, J Castilla, J Safar, J Safar, Jason Bartz, Jason M. Wilham, JC Manson, JI Kim, JI Kim, JM Wilham, JR Silveira, K-M Pan, KA Nishina, KA Nishina, KM Green, LI McGuire, MA Barria, ME Bruce, MH Tattum, MP McKinley, N Makarava, P Piccardo, P Piccardo, P Saa, P Tixador, PE Bendheim, R Atarashi, R Rubenstein, RA Bessen, RA Bessen, RM Barron, RM Barron, Rona Barron, Sarah Vascellari, SB Prusiner, SB Prusiner, SJ DeArmond, SP Mahal, T Kitamoto, V Smirnovas, Y Murayama   +70 more
core   +3 more sources

Prion disease: experimental models and reality [PDF]

, 2017
The understanding of the pathogenesis and mechanisms of diseases requires a multidisciplinary approach, involving clinical observation, correlation to pathological processes, and modelling of disease mechanisms.
Brandner, S, Jaunmuktane, Z
core   +1 more source

Imaging and CSF analyses effectively distinguish CJD from its mimics [PDF]

, 2017
OBJECTIVE: To review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis. METHODS: Review the
Collinge, J, Green, A, Hyare, H, Mead, S, Rudge, P   +4 more
core   +1 more source

An autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion assay. [PDF]

Prion, 2017
Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Mimuro M, Kimura A, Satoh K, Kitamoto T, Yoshida M, Inuzuka T.   +9 more
europepmc   +2 more sources

CJD mimics and chameleons [PDF]

, 2017
Rapidly progressive dementia mimicking Creutzfeldt-Jakob disease (CJD) is a relatively rare presentation but a rewarding one to become familiar with, as the potential diagnoses range from the universally fatal to the completely reversible.
Mead, S, Rudge, P
core   +1 more source

Early preclinical detection of prions in the skin of prion-infected animals

Nature Communications, 2019
There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the ...
Zerui Wang, Matteo Manca, Aaron Foutz, Manuel V. Camacho, Gregory J. Raymond, Brent Race, Christina D. Orru, Jue Yuan, Pingping Shen, Baiya Li, Yue Lang, Johnny Dang, Alise Adornato, Katie Williams, Nicholas R. Maurer, Pierluigi Gambetti, Bin Xu, Witold Surewicz, Robert B. Petersen, Xiaoping Dong, Brian S. Appleby, Byron Caughey, Li Cui, Qingzhong Kong, Wen-Quan Zou   +24 more
doaj   +1 more source