Results 41 to 50 of about 10,380 (154)

Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt‐Jakob disease

Clinical Case Reports, 2021
Sporadic Creutzfeldt‐Jakob disease should be considered in any case of rapid neuropsychiatric decline. While neuropathological examination of a brain biopsy specimen remains the only definitive diagnostic method and real‐time quaking‐induced conversion ...
Elina T Ziukelis, Vasu Keshav Sharma, James J Gome   +2 more
doaj   +1 more source

An autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion assay. [PDF]

Prion, 2017
Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Mimuro M, Kimura A, Satoh K, Kitamoto T, Yoshida M, Inuzuka T.   +9 more
europepmc   +2 more sources

Toward an Early Real-Time Quaking-Induced Conversion-Based Diagnostic Biomarker for Lewy Body-Related Synucleinopathies. [PDF]

Mov Disord Clin Pract, 2020
[no abstract available]
Magrinelli F, Tinazzi M, Bhatia KP.
europepmc   +6 more sources

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

Annals of Clinical and Translational Neurology, 2020
Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis of sporadic Creutzfeldt–Jakob disease.
Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source

Disagreement between postmortem immunohistochemistry (IHC) and real-time quaking-induced conversion (RT-QuIC) results.

, 2022
Disagreement between postmortem immunohistochemistry (IHC) and real-time quaking-induced conversion (RT-QuIC) results.
Stuart S. Lichtenberg (14129070), Daniel P. Walsh (13985259), Kate R. Burgener (14129067), Joel A. Pedersen (171748), Aaron Lomax (14129073), Daniel J. Storm (5017322)   +5 more
core   +1 more source

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Molecular Neurodegeneration, 2021
Background Detection of the pathological and disease-associated alpha-synuclein (αSynD) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD).
Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven Alexander Gunzler, Giorgio Giaccone, Roberto Eleopra, Shu Guang Chen, Fabio Moda   +18 more
doaj   +1 more source

mCWD seeding activity in the spinal cord of Ndst1^f/ftga20^+/+SynCre- and SynCre+ mice using real-time quaking-induced conversion.

, 2023
mCWD seeding activity in the spinal cord of Ndst1f/ftga20+/+SynCre- and SynCre+ mice using real-time quaking-induced conversion.
Jeffrey J. Iliff (11808058), Adela Malik (17041664), Christopher Barback (6989393), Daniel R. Sandoval (10037976), Christina J. Sigurdson (180096), Christina D. Orrù (5651755), K. Peter R. Nilsson (8037491), Olivia R. Thomas (17041667), David R. Vera (1273554), Allison Kraus (602160), Ryotaro Ogawa (15018621), Byron Caughey (236055), Patricia Aguilar-Calvo (532439), Katrin Soldau (174488), Mckenzie B. Riley (17041670), Chrissa A. Dwyer (9197724), Jaidev Bapat (8282310), Heidi G. Standke (12981384), Jeffrey D. Esko (216312), Donald P. Pizzo (15004748)   +19 more
core   +1 more source

Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC

BMC Research Notes, 2018
Objective Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that ...
Soyoun Hwang, Trudy Tatum, Semakaleng Lebepe-Mazur, Eric M. Nicholson   +3 more
doaj   +1 more source

Atypical Case of VV1 Creutzfeldt–Jakob Disease Subtype: Case Report

Frontiers in Neurology, 2022
Creutzfeldt–Jakob disease (CJD) is a rare form of rapidly progressive, neurodegenerative disease that results from the misfolding and accumulation of an aberrant, disease-associated prion protein (PrPD).
Adrianna E. Carrasco, Brian S. Appleby, Ignazio Cali, Hamid R. Okhravi   +3 more
doaj   +1 more source

Real-time Quaking-induced Conversion Assay for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in a Living Patient. [PDF]

Infect Dis (Auckl), 2019
Creutzfeldt-Jakob disease (CJD) is the most common prion disease in humans with an incidence of one case per million inhabitants worldwide. The sporadic form of CJD (sCJD) is spontaneous and accounts for 85% of cases. Its symptoms include rapidly progressive dementia, ataxic gait, personality changes, myoclonus, coma, and eventually death.
Reddy VD, Hamed A, Settipalle N, Jande S, Rahman S, Szabella ME, Boghossian J.   +6 more
europepmc   +4 more sources