Results 21 to 30 of about 4,479 (143)

Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion. [PDF]

Biomed Res Int, 2017
Prions composed of pathogenic scrapie prion protein (PrPSc) are infectious pathogens that cause progressive neurological conditions known as prion diseases or transmissible spongiform encephalopathies.
Kang HE, Mo Y, Abd Rahim R, Lee HM, Ryou C.   +4 more
europepmc   +4 more sources

Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt–jakob disease:An international study [PDF]

Annals of Neurology, 2016
Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt\u2013Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to ...
Atarashi , Ryuichiro, Cheng , Keding, Collins, Steven, Cramm , Maria, Cras , Patrick, de Vil , Bart, Equestre, Michele, Fairfoul , Graham, Green, Alison, Grznarova , Katarina, Haik, Stéphane, Knox , David, McGuire, Lynne I., Parchi, Piero, Pocchiari, Maurizio, Poggiolini , Ilaria, Poleggi, Anna, Sarros , Shannon, Satoh, Katsuya, Schmitz, Matthias, Shi , Song, Suardi, Silvia, Tagliavini, Fabrizio, Zerr, Inga   +23 more
core   +5 more sources

Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion [PDF]

BMC Research Notes
Objective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson, Justin J. Greenlee, Soyoun Hwang   +2 more
doaj   +2 more sources

Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases [PDF]

Scientific Reports, 2021
The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to ...
Tze How Mok, Akin Nihat, Connie Luk, Danielle Sequeira, Mark Batchelor, Simon Mead, John Collinge, Graham S. Jackson   +7 more
doaj   +2 more sources

Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network. [PDF]

Eur J Neurol, 2022
McKenzie N, Piconi G, Culeux A, Hammarin AL, Stergiou C, Tzartos S, Versleijen AAM, van de Geer J, Cras P, Cardone F, Ladogana A, Mannana A, Rossi M, Bongianni M, Perra D, Regelsberger G, Klotz S, Hornemann S, Aguzzi A, Schmitz M, Andrews M, Burns K, Haïk S, Ruiz-García R, Verner-Carlsson J, Tzartos J, Verbeek MM, De Vil B, Poleggi A, Parchi P, Zanusso G, Gelpi E, Frontzek K, Reimann R, Hermann P, Zerr I, Pal S, Green A.   +37 more
europepmc   +2 more sources

Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies. [PDF]

Neurology, 2021
Rossi M, Baiardi S, Teunissen CE, Quadalti C, van de Beek M, Mammana A, Stanzani-Maserati M, Van der Flier WM, Sambati L, Zenesini C, Caughey B, Capellari S, Lemstra AW, Parchi P.   +13 more
europepmc   +2 more sources

Toward an Early Real-Time Quaking-Induced Conversion-Based Diagnostic Biomarker for Lewy Body-Related Synucleinopathies. [PDF]

Mov Disord Clin Pract, 2020
Magrinelli F, Tinazzi M, Bhatia KP.
europepmc   +3 more sources

Application value of real ⁃ time quaking ⁃ induced conversion technology in clinical diagnosis of Creutzfeldt⁃Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Creutzfeldt⁃Jakob disease (CJD) is a group of clinically rare neurodegenerative diseases caused by misfolding of prion proteins, and is the most common type of human prion diseases.
Dian HE
doaj   +1 more source

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients. [PDF]

Brain Commun, 2020
Scialò C, Tran TH, Salzano G, Novi G, Caponnetto C, Chiò A, Calvo A, Canosa A, Moda F, Caroppo P, Silani V, Ticozzi N, Ratti A, Borroni B, Benussi L, Ghidoni R, Furlanis G, Manganotti P, Senigagliesi B, Parisse P, Brasselet R, Buratti E, Legname G.   +22 more
europepmc   +2 more sources

α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. [PDF]

Mov Disord, 2020
Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A, Kanthasamy AG.   +6 more
europepmc   +2 more sources