quicR: An R library for streamlined data handling of real-time quaking induced conversion assays
SoftwareXReal-time quaking induced conversion (RT-QuIC) has become a valuable diagnostic tool for protein misfolding disorders such as Creutzfeldt–Jakob disease and Parkinson’s disease.
Gage R. Rowden, Peter A. Larsen
doaj +2 more sources
Application of real-time quaking-induced conversion in Creutzfeldt-Jakob disease surveillance. [PDF]
J Neurol, 2023 Abstract Background Evaluation of the application of CSF real-time quaking-induced conversion in Creutzfeldt–Jakob disease surveillance to investigate test accuracy, influencing factors, and associations with disease incidence.
Hermann P +10 more
europepmc +5 more sources
Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion [PDF]
BMC Research NotesObjective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson +2 more
doaj +2 more sources
Concordance of cerebrospinal fluid real‐time quaking‐induced conversion across the European Creutzfeldt–Jakob Disease Surveillance Network [PDF]
European Journal of Neurology, 2022 Anna Poleggi +2 more
exaly +2 more sources
Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan. [PDF]
J Vet Med Sci, 2021 There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions.
Suzuki A +6 more
europepmc +5 more sources
Real-time quaking-induced conversion [PDF]
Prion, 2011 We recently developed a new in vitro amplification technology, designated "real-time quaking-induced conversion (RT-QUIC)", for detection of the abnormal form of prion protein (PrPSc) in easily accessible specimens such as cerebrospinal fluid (CSF).
Ryuichiro, Atarashi +3 more
openaire +2 more sources
α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism. [PDF]
Ann Neurol, 2019 A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real‐time quaking‐induced conversion (RT‐QuIC) assay to detect α‐synuclein (α‐syn) aggregates in cerebrospinal fluid (CSF) of 118 patients with parkinsonism of uncertain clinical etiology and 52
van Rumund A +5 more
europepmc +6 more sources
Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates [PDF]
Prion, 2020 Sarah Cooper +2 more
exaly +2 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Creutzfeldt⁃Jakob disease (CJD) is a group of clinically rare neurodegenerative diseases caused by misfolding of prion proteins, and is the most common type of human prion diseases.
Dian HE
doaj +1 more source
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion [PDF]
Acta NeuropathologicaMoses Leavens +2 more
exaly +2 more sources