Results 31 to 40 of about 4,479 (143)

Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt‐Jakob disease

Clinical Case Reports, 2021
Sporadic Creutzfeldt‐Jakob disease should be considered in any case of rapid neuropsychiatric decline. While neuropathological examination of a brain biopsy specimen remains the only definitive diagnostic method and real‐time quaking‐induced conversion ...
Elina T Ziukelis, Vasu Keshav Sharma, James J Gome   +2 more
doaj   +1 more source

α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism. [PDF]

Ann Neurol, 2019
van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM.   +5 more
europepmc   +2 more sources

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

Annals of Clinical and Translational Neurology, 2020
Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis of sporadic Creutzfeldt–Jakob disease.
Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Molecular Neurodegeneration, 2021
Background Detection of the pathological and disease-associated alpha-synuclein (αSynD) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD).
Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven Alexander Gunzler, Giorgio Giaccone, Roberto Eleopra, Shu Guang Chen, Fabio Moda   +18 more
doaj   +1 more source

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion. [PDF]

Acta Neuropathol
Mielke JK, Klingeborn M, Schultz EP, Markham EL, Reese ED, Alam P, Mackenzie IR, Ly CV, Caughey B, Cashman NR, Leavens MJ.   +10 more
europepmc   +2 more sources

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification [PDF]

, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Bougard, Daisy, Bruyère-Ostells, Lilian, Bélondrade, Maxime, Fournier-Wirth, Chantal, Green, Alison J E, Knight, Richard S, Lehmann, Sylvain, Mayran, Charly, Will, Robert G   +8 more
core   +3 more sources

Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC

BMC Research Notes, 2018
Objective Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that ...
Soyoun Hwang, Trudy Tatum, Semakaleng Lebepe-Mazur, Eric M. Nicholson   +3 more
doaj   +1 more source

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains [PDF]

, 2015
Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced Conversion (RT-QuIC) would facilitate prion disease diagnosis, surveillance ...
Caughey, Byron, Gambetti, Pierluigi, Ghetti, Bernardino, Groveman, Bradley R., Hughson, Andrew G., Nonno, Romolo, Orrú, Christina D., Raymond, Lynne D., Zou, Wenquan   +8 more
core   +2 more sources

Atypical Case of VV1 Creutzfeldt–Jakob Disease Subtype: Case Report

Frontiers in Neurology, 2022
Creutzfeldt–Jakob disease (CJD) is a rare form of rapidly progressive, neurodegenerative disease that results from the misfolding and accumulation of an aberrant, disease-associated prion protein (PrPD).
Adrianna E. Carrasco, Brian S. Appleby, Ignazio Cali, Hamid R. Okhravi   +3 more
doaj   +1 more source

In vitro amplification of H-type atypical bovine spongiform encephalopathy by protein misfolding cyclic amplification [PDF]

, 2016
The in vitro amplification of prions by serial protein misfolding cyclic amplification has been shown to detect PrPSc to levels at least as sensitive as rodent bioassay but in a fraction of the time.
Ben C. Maddison, Jeffrey M, Keith Bishop, Kevin C. Gough, Matthew J. O‘Connor, Robert G. Workman   +5 more
core   +2 more sources