Results 11 to 20 of about 20,909,028 (154)

Real-Time Quaking-Induced Conversion Detection of Bovine Spongiform Encephalopathy Prions in a Subclinical Steer [PDF]

Frontiers in Veterinary Science, 2018
Bovine spongiform encephalopathy (BSE) belongs to a group of fatal prion diseases that result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that accumulates in the brain.
Soyoun Hwang, M. Heather West Greenlee, Anne Balkema-Buschmann, Martin H. Groschup, Eric M. Nicholson, Justin J. Greenlee   +5 more
doaj   +6 more sources

Improved Real-Time Quaking Induced Conversion for Early Diagnostics of Creutzfeldt-Jakob Disease in Denmark. [PDF]

Int J Mol Sci, 2023
Cerebrospinal fluid-based real-time quaking-induced conversion (CSF RT-QuIC) is currently the most prominent method for early detection of sporadic Creutzfeldt–Jakob disease (sCJD), the most common prion disease.
Bsoul R, Lund EL, Burns K, Andrews M, McKenzie N, Green A, Areškevičiūtė A.   +6 more
europepmc   +9 more sources

α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism. [PDF]

Ann Neurol, 2019
A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real‐time quaking‐induced conversion (RT‐QuIC) assay to detect α‐synuclein (α‐syn) aggregates ...
van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM.   +5 more
europepmc   +10 more sources

PAD-Beads enrichment enhances detection of PrPSc using real-time quaking-induced conversion [PDF]

BMC Research Notes, 2019
Objective Scrapie is a transmissible spongiform encephalopathy (TSE) that naturally occurs in sheep and goats. This fatal neurodegenerative disease results from misfolding of the normal cellular prion protein (PrPC) to a pathogenic prion protein form ...
Soyoun Hwang, Rohana P. Dassanayake, Eric M. Nicholson   +2 more
doaj   +5 more sources

Application of real-time quaking-induced conversion in Creutzfeldt-Jakob disease surveillance. [PDF]

J Neurol, 2023
Background Evaluation of the application of CSF real-time quaking-induced conversion in Creutzfeldt–Jakob disease surveillance to investigate test accuracy, influencing factors, and associations with disease incidence.
Hermann P, Schmitz M, Cramm M, Goebel S, Bunck T, Schütte-Schmidt J, Schulz-Schaeffer W, Stadelmann C, Matschke J, Glatzel M, Zerr I.   +10 more
europepmc   +6 more sources

Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network. [PDF]

Eur J Neurol, 2022
Background and purpose: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) has a high degree of sensitivity and specificity for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) and this has led to its being included in ...
McKenzie N, Piconi G, Culeux A, Hammarin AL, Stergiou C, Tzartos S, Versleijen AAM, van de Geer J, Cras P, Cardone F, Ladogana A, Mannana A, Rossi M, Bongianni M, Perra D, Regelsberger G, Klotz S, Hornemann S, Aguzzi A, Schmitz M, Andrews M, Burns K, Haïk S, Ruiz-García R, Verner-Carlsson J, Tzartos J, Verbeek MM, De Vil B, Poleggi A, Parchi P, Zanusso G, Gelpi E, Frontzek K, Reimann R, Hermann P, Zerr I, Pal S, Green A.   +37 more
europepmc   +7 more sources

Prion Diagnosis: Application of Real-Time Quaking-Induced Conversion. [PDF]

Biomed Res Int, 2017
Prions composed of pathogenic scrapie prion protein (PrPSc) are infectious pathogens that cause progressive neurological conditions known as prion diseases or transmissible spongiform encephalopathies.
Kang HE, Mo Y, Abd Rahim R, Lee HM, Ryou C.   +4 more
europepmc   +5 more sources

Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan. [PDF]

J Vet Med Sci, 2021
There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-
Suzuki A, Sawada K, Erdenebat T, Yamasaki T, Tobiume M, Suga K, Horiuchi M.   +6 more
europepmc   +6 more sources

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients. [PDF]

Brain Commun, 2020
The pathological deposition of the transactive response DNA-binding protein of 43 kDa occurs in the majority (∼97%) of amyotrophic lateral sclerosis and in around 45% of frontotemporal lobar degeneration cases.
Scialò C, Tran TH, Salzano G, Novi G, Caponnetto C, Chiò A, Calvo A, Canosa A, Moda F, Caroppo P, Silani V, Ticozzi N, Ratti A, Borroni B, Benussi L, Ghidoni R, Furlanis G, Manganotti P, Senigagliesi B, Parisse P, Brasselet R, Buratti E, Legname G.   +22 more
europepmc   +5 more sources

α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. [PDF]

Mov Disord, 2020
AbstractBackgroundIdentification of a peripheral biomarker is a major roadblock in the diagnosis of PD. Immunohistological identification of p‐serine 129 α‐synuclein in the submandibular gland tissues of PD patients has been recently reported.ObjectiveWe report on a proof‐of‐principle study for using an ultra‐sensitive and specific, real‐time quaking ...
Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A, Kanthasamy AG.   +6 more
europepmc   +5 more sources