Results 231 to 240 of about 74,938 (266)
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Cerebral A1 adenosine receptors (A1AR) in liver cirrhosis

European Journal of Nuclear Medicine and Molecular Imaging, 2007
The cerebral mechanisms underlying hepatic encephalopathy (HE) are poorly understood. Adenosine, a neuromodulator that pre- and postsynaptically modulates neuronal excitability and release of classical neurotransmitters via A(1) adenosine receptors (A(1)AR), is likely to be involved.
Boy, Christian   +10 more
openaire   +3 more sources

Partners for adenosine A1 receptors.

Journal of molecular neuroscience : MN, 2005
G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological diseases. Using adenosine A1 receptors (A1Rs) as paradigm of GPCRs, this review focuses on how protein-protein interactions, from monomers to heteromers, can contribute to hormone/neurotransmitter/neuromodulator regulation.
Franco R   +9 more
openaire   +2 more sources

REM sleep deprivation up-regulates adenosine A1 receptors

Brain Research, 1987
Adenosine receptor binding was determined in the brains of rats deprived of rapid eye movement (REM) sleep for 48 and 96 h using [3H]L-phenylisopropyladenosine. Adenosine A1 receptors (Bmax) were significantly increased in the cortex and corpus striatum, and this increase was sleep-specific.
G, Yanik, M, Radulovacki
openaire   +2 more sources

Alterations of adenosine A1 receptors in morphine dependence

Brain Research, 1994
The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors ...
G B, Kaplan   +2 more
openaire   +2 more sources

Allosteric Modulators of the A1 Adenosine receptor

2008
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain such as neurophatic pain or cardiac disease.
BARALDI, Pier Giovanni   +2 more
openaire   +2 more sources

Affinity chromatography in purification of A1 adenosine receptors

Journal of Chromatography A, 1992
Purification of A1 adenosine receptor of rat brain membranes was performed using a newly developed affinity gel employing xanthine amine congener (XAC) as an immobilized ligand. The A1 adenosine receptor was solubilized with digitonin-cholate from brain membranes and then purified by a sequential use of affinity chromatography on XAC-agarose ...
openaire   +2 more sources

Adenosine A1 Receptors

2010
Jean-Michel Scherrmann   +199 more
openaire   +1 more source

The adenosine pathway in immuno-oncology

Nature Reviews Clinical Oncology, 2020
Bertrand Allard   +2 more
exaly  

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature, 2021
Christopher Draper-Joyce   +2 more
exaly  

Adenosine A1 receptors mediate preconditioning

Journal of Molecular and Cellular Cardiology, 1992
openaire   +1 more source

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