Results 21 to 30 of about 119,693 (290)

Photoaffinity labeling of A1-adenosine receptors. [PDF]

Journal of Biological Chemistry, 1985
The ligand-binding subunit of the A1-adenosine receptor has been identified by photoaffinity labeling. A photolabile derivative of R-N6-phenylisopropyladenosine, R-2-azido-N6-p-hydroxyphenylisopropyladenosine (R-AHPIA), has been synthesized as a covalent specific ligand for A1-adenosine receptors.
Klotz, Karl-Norbert, Cristalli, G., Grifantini, M., Vittori, S., Lohse, M. J.   +4 more
openaire   +3 more sources

Stimulation of endothelial adenosine Al receptors enhances adhesion of neutrophils in the intact guinea pig coronary system [PDF]

, 1994
Objective: The primary aim was to determine the action of pathophysiologically relevant adenosine concentrations (0.1-1 μM) on adhesion of neutrophils to coronary endothelium.
Becker, Bernhard F., Gerlach, E., Raschke, P., Zahler, Stefan   +3 more
core   +1 more source

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2018
It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz, Natalie Rotermund, Katarzyna Grzelka, Jan Benz, Christian Lohr, Daniela Hirnet   +5 more
doaj   +1 more source

Selective reduction of neurotransmitter release by cAMP-dependent pathways in mouse detrusor [PDF]

, 2022
Parasympathetic nerve-mediated contractions of detrusor smooth muscle are generated by ATP and acetylcholine (ACh) release from efferent nerve terminals. In humans, ACh is responsible for detrusor contractions in normal human bladders, whereas ATP has an
Chakrabarty, Basu, Drake, Marcus J, Fry, Christopher H, Kanai, Anthony J   +3 more
core   +3 more sources

Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs [PDF]

, 1989
The effects of endogenously released adenosine on the excitability of hippocampal neurons were studied using the novel and highly selective adenosine A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX).
Alzheimer, Christian, Sutor, Bernd, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor

Scientific Reports, 2018
Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A1 receptor (A1AR), structural binding modes of the receptor PAMs remain unknown.
Yinglong Miao, A. Bhattarai, A. T. Nguyen, A. Christopoulos, L. May   +4 more
semanticscholar   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review [PDF]

, 2014
Abbreviations: A2A, adenosine subtype A2A receptor; A1, adenosine subtype A1 receptor; ABC, avidin biotin complex; ABD rat, aortic barodenervated rat; α2 AR, alpha 2 adrenergic receptor; αMNE, alpha methyl norepinephrine; ATP, adenosine triphosphate ...
Abdel-Rahman, Abdel-Rahman, Akbar, Arslan, Barac, Barraco, Barraco, Barraco, Beukers, Bonham, Bousquet, Bousquet, Bousquet, Bousquet, Braga, Bruban, Bruban, Chan, Chan, Chen, Choe, Colombari, de Paula, Dubar, Dunwiddie, Edwards, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, Ernsberger, Ernsberger, Ernsberger, Ernsberger, Estato, Feldman, Fredholm, Freissmuth, Fresco, Guyenet, Guyenet, Haxhiu, Head, Head, Ibrahim, Iliff, Jastrzebski, Jockers, Kable, Kumagai, Lee, Medvedev, Nassar, Nassar, Nassar, Ongini, Paes-de-Carvalho, Poulsen, Reis, Schulte, Schulte, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Separovic, Separovic, Shen, Spyer, St Lambert, Sun, Szabo, Szabo, Takeda, Tan, Tao, Thomas, Thomas, Tingley, Tolentino-Silva, van Zwieten, Wang, Wang, Wyatt, Yamamoto, Yang, Zhang, Zhang, Zhang   +94 more
core   +2 more sources

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

Molecules, 2017
The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the ...
J. Stockwell, Elisabet Jakova, F. Cayabyab   +2 more
semanticscholar   +1 more source