Results 151 to 160 of about 1,239,345 (193)

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

Mishra S, Yadav MK, Dalal A, Ganguly M, Yadav R, Sawada K, Tiwari D, Roy N, Banerjee N, Fung JN, Marallag J, Cui CS, Li XX, Lee JD, Dsouza CA, Saha S, Sarma P, Rawat G, Zhu H, Khant HA, Clark RJ, Sano FK, Banerjee R, Woodruff TM, Nureki O, Gati C, Shukla AK.   +26 more
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Expression of the anaphylatoxin C5a receptor in non-myeloid cells

Molecular Immunology, 1999
C5, a 74 amino acid peptide cleaved from the complement protein C5, represents the most potent anaphylatoxin and possesses inflammatory as well as immunomodulatory activities. In the past, expression of the receptor for the anaphylatoxin C5a (C5aR) has been thought to be restricted to cells of myeloid origin.
O Götze, J Zwirner
exaly   +3 more sources

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

Annual Review of Immunology, 1994
The molecular cloning of the C5a receptor places this molecule in the superfamily of G-protein coupled receptors. This superfamily is characterized by the presence of signature motifs including seven hydrophobic domains which span the cell membrane and impart a predicted serpentine topology to the receptor proteins.
Norma P Gérard
exaly   +4 more sources

The chemotactic receptor for human C5a anaphylatoxin

Nature, 1991
Host defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic factor that directs the approach of phagocytic cells. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and ...
N P, Gerard, C, Gerard
openaire   +2 more sources

Distribution of Rat C5a Anaphylatoxin Receptor

Microbiology and Immunology, 2002
AbstractThe anaphylatoxin, complement 5a (C5a), plays a key role in mediating various inflammatory reactions following complement activation. Several investigators have reported that C5a receptor (C5aR) is expressed in non‐myeloid cells under certain conditions or in different cell lines.
Hiroyasu, Akatsu, Masayoshi, Abe, Takashi, Miwa, Hisashi, Tateyama, Seiji, Maeda, Noriko, Okada, Kiyohide, Kojima, Hidechika, Okada   +7 more
openaire   +2 more sources

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

Biochemistry, 2008
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich, Garland R, Marshall, Thomas J, Baranski   +2 more
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Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

Brain Research, 2001
Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes.
S, Nataf, S W, Levison, S R, Barnum
openaire   +2 more sources

Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor

Immunogenetics, 1999
A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence of 2.8%) and among patients with end ...
François Marceau, Magdalena Bachvarova, D R Bachvarov   +2 more
exaly   +3 more sources

Receptors for the Anaphylatoxin C5a (CD88) on Human Mesangial Cells

The Journal of Immunology, 1998
Abstract In these studies, we determined whether there are receptors for the anaphylatoxin C5a (C5aR, CD88) on human mesangial cells (HMC). To prepare Abs to C5aR, we first synthesized an immunogenic peptide spanning residues 8–32 of the molecule, and this peptide was used to immunize rabbits.
W A, Wilmer, P T, Kaumaya, J A, Ember, F G, Cosio   +3 more
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Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists

International Immunopharmacology, 2021
The complement system is an essential component of innate immunity. Its activation generates the effector cleavage proteins, anaphylatoxins C3a and C5a, that exert activity by interacting with three structurally related seven-transmembrane receptors. C3a activates C3aR, whilst C5a interacts with both C5aR1 and C5aR2 with equal potency.
Li, Xaria X., Clark, Richard J., Woodruff, Trent M.   +2 more
openaire   +4 more sources