Results 161 to 170 of about 1,239,345 (193)

Anaphylatoxin C5a modulation of an alpha-adrenergic receptor system in the rat hypothalamus

Journal of Neuroimmunology, 1985
C5a anaphylatoxin injected via implanted cannulae into the perifornical region of the hypothalamus stimulated eating in sated rats. C5a also attenuated carbamyl choline-induced drinking, and carbamyl choline inhibited C5a-induced eating, a mutual inhibition characteristic of the adrenergic-cholinergic interactions at this site.
Tony E Hugli, N Schupf
exaly   +3 more sources

Identification and synthesis of a receptor binding site of human anaphylatoxin C5a

Journal of Medicinal Chemistry, 1991
C5a is a 74 amino acid polypeptide that likely plays an important role in the pathogenesis of a number of inflammatory diseases. Therefore, the discovery of a C5a antagonist is of considerable therapeutic interest. A series of peptides designed to survey various regions of the molecule was synthesized by solid-phase peptide synthesis and evaluated for ...
M, Kawai, D A, Quincy, B, Lane, K W, Mollison, J R, Luly, G W, Carter   +5 more
openaire   +2 more sources

Expression of Receptors for Anaphylatoxins C3a and C5a on Rat Islet Preparations

Transplantation Proceedings, 2011
Complement activation has been implicated in the development of the instant blood-mediated inflammatory reaction (IBMIR). In particular, anaphylatoxins C3a and C5a elicit a broad range of proinflammatory effects, including chemotaxis of inflammatory cells and cytokine release.
K, Tokodai, M, Goto, A, Inagaki, T, Imura, W, Nakanishi, S, Satomi   +5 more
openaire   +2 more sources

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes

The Journal of Immunology, 1995
Abstract The C fragment C5a exerts its important physiologic and pathologic effects through interaction with a specific C5a receptor (C5aR) which is highly expressed on polymorphonuclear leukocytes and some other leukocytes. The presence of this receptor on epithelia and endothelia has recently been documented, raising the possibility
P, Gasque, P, Chan, M, Fontaine, A, Ischenko, M, Lamacz, O, Götze, B P, Morgan   +6 more
openaire   +2 more sources

Construction and expression of a novel recombinant anaphylatoxin, C5a-N19, as a probe for the human C5a receptor

Biochemistry, 1990
We have constructed a novel recombinant C5a anaphylatoxin (C5a-N19) containing a 19-residue amino-terminal extension peptide, using a plasmid vector which secretes the nascent polypeptide to the Escherichia coli periplasmic space. C5a-N19 was purified from cell lysates by immunoaffinity chromatography using a monoclonal antibody which recognizes a ...
N P, Gerard, C, Gerard
openaire   +2 more sources

Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages. [PDF]

Journal of Experimental Medicine, 1982
Human C5a anaphylatoxin is known to be a potent mediator of the acute inflammatory response. It serves to trigger a wide variety of neutrophil responses after binding to a specific cellular receptor. We have now demonstrated that this bioactive glycopolypeptide is also bound to a specific receptor found on murine resident peritoneal macrophages ...
Chenoweth, D E, Goddman, M G, Weigle, W O   +2 more
exaly   +3 more sources

A selection system to study C5a–C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5aAla27

Gene, 1997
Binding and effector domains of the human anaphylatoxin C5a have been determined by either site directed mutagenesis or synthetic peptide studies. However, the lack of specific selection methods, which allow direct investigation of C5a-C5a-receptor interaction made these studies laborious.
M, Hennecke, A, Kola, M, Baensch, A, Wrede, A, Klos, W, Bautsch, J, Köhl   +6 more
openaire   +2 more sources

Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis

Journal of Neuroimmunology, 1998
In this study, we investigated the expression of the C5aR in spinal cords of Lewis rats with experimental allergic encephalomyelitis (EAE). Using in situ hybridization (ISH) we analyzed the kinetics of C5aR at different time points of EAE (preclinical stage, clinical peak, remission phase).
S, Nataf, N, Davoust, S R, Barnum
openaire   +2 more sources

Cellular receptors to the anaphylatoxins C3a and C5a.

Biochemical Society symposium, 1987
A single component in the plasma membrane of human polymorphonuclear leukocytes (hPMN) has been identified as the binding site for C5a. Labelled human C5a can be cross-linked to a 48,000-Mr membrane component on the hPMN surface by using the bifunctional reagent ethylene glycol bis(succinimidyl succinate).
R, Huey, Y, Fukuoka, P D, Hoeprich, T E, Hugli   +3 more
openaire   +1 more source

Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques

Atherosclerosis, 2007
The anaphylatoxins C3a and C5a are potent chemotactic and pro-inflammatory peptides that are released during complement activation, and recent clinical work have suggested them a role in acute coronary events. Here we studied whether human coronary plaques express anaphylatoxin receptors C3aR and C5aR, i.e. whether they have the potential to respond to
Riina, Oksjoki, Petri, Laine, Satu, Helske, Pirjo, Vehmaan-Kreula, Mikko I, Mäyränpää, Philippe, Gasque, Petri T, Kovanen, Markku O, Pentikäinen   +7 more
openaire   +2 more sources