Results 171 to 180 of about 6,320 (210)

C5L2: a controversial receptor of complement anaphylatoxin, C5a

The FASEB Journal, 2012
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.   +4 more
openaire   +5 more sources

Expression of the anaphylatoxin C5a receptor in non-myeloid cells

Molecular Immunology, 1999
C5, a 74 amino acid peptide cleaved from the complement protein C5, represents the most potent anaphylatoxin and possesses inflammatory as well as immunomodulatory activities. In the past, expression of the receptor for the anaphylatoxin C5a (C5aR) has been thought to be restricted to cells of myeloid origin.
J, Zwirner, A, Fayyazi, O, Götze
exaly   +3 more sources

Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor

Immunogenetics, 1999
A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence of 2.8%) and among patients with end ...
François Marceau
exaly   +3 more sources

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

Brain Research, 2001
Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes.
S, Nataf, S W, Levison, S R, Barnum
openaire   +2 more sources

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

Annual Review of Immunology, 1994
The molecular cloning of the C5a receptor places this molecule in the superfamily of G-protein coupled receptors. This superfamily is characterized by the presence of signature motifs including seven hydrophobic domains which span the cell membrane and impart a predicted serpentine topology to the receptor proteins.
C, Gerard, N P, Gerard
exaly   +4 more sources

Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists

International Immunopharmacology, 2021
The complement system is an essential component of innate immunity. Its activation generates the effector cleavage proteins, anaphylatoxins C3a and C5a, that exert activity by interacting with three structurally related seven-transmembrane receptors. C3a activates C3aR, whilst C5a interacts with both C5aR1 and C5aR2 with equal potency.
Li, Xaria X., Clark, Richard J., Woodruff, Trent M.   +2 more
openaire   +3 more sources

Receptors for the Anaphylatoxin C5a (CD88) on Human Mesangial Cells

The Journal of Immunology, 1998
Abstract In these studies, we determined whether there are receptors for the anaphylatoxin C5a (C5aR, CD88) on human mesangial cells (HMC). To prepare Abs to C5aR, we first synthesized an immunogenic peptide spanning residues 8–32 of the molecule, and this peptide was used to immunize rabbits.
W A, Wilmer, P T, Kaumaya, J A, Ember, F G, Cosio   +3 more
openaire   +2 more sources

Identification and synthesis of a receptor binding site of human anaphylatoxin C5a

Journal of Medicinal Chemistry, 1991
C5a is a 74 amino acid polypeptide that likely plays an important role in the pathogenesis of a number of inflammatory diseases. Therefore, the discovery of a C5a antagonist is of considerable therapeutic interest. A series of peptides designed to survey various regions of the molecule was synthesized by solid-phase peptide synthesis and evaluated for ...
M, Kawai, D A, Quincy, B, Lane, K W, Mollison, J R, Luly, G W, Carter   +5 more
openaire   +2 more sources

Expression of Receptors for Anaphylatoxins C3a and C5a on Rat Islet Preparations

Transplantation Proceedings, 2011
Complement activation has been implicated in the development of the instant blood-mediated inflammatory reaction (IBMIR). In particular, anaphylatoxins C3a and C5a elicit a broad range of proinflammatory effects, including chemotaxis of inflammatory cells and cytokine release.
K, Tokodai, M, Goto, A, Inagaki, T, Imura, W, Nakanishi, S, Satomi   +5 more
openaire   +2 more sources

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes

The Journal of Immunology, 1995
Abstract The C fragment C5a exerts its important physiologic and pathologic effects through interaction with a specific C5a receptor (C5aR) which is highly expressed on polymorphonuclear leukocytes and some other leukocytes. The presence of this receptor on epithelia and endothelia has recently been documented, raising the possibility
P, Gasque, P, Chan, M, Fontaine, A, Ischenko, M, Lamacz, O, Götze, B P, Morgan   +6 more
openaire   +2 more sources