Results 231 to 240 of about 35,349,291 (244)

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Antihypertensive Drugs as Potential Repositioning Options for Melanoma: A Map of Pre-Clinical Evidence. [PDF]

Diseases
Mieres NG, Oliveira K, Marques NCB, Azorza NMC, Borba HHL, Pontarolo R, Sari MHM, Bonini JS, Reolon JB, Lazo REL, Ferreira LM.   +10 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Long-Term Betaine Supplementation Increases Creatinine Clearance and Upregulates MAS and AT2 Receptor Expression in Spontaneously Hypertensive Rat Kidneys.

Kidney Blood Press Res
Koper M, Jaworska K, Kopacz W, Samborowska E, Ufnal M.   +4 more
europepmc   +1 more source

Antibodies to Non-HLA Antigens and Their Role in Organ Transplant Rejection. [PDF]

Int J Immunogenet
Jaklová K, Vychytilová K, Glosová A, Slavcev A.   +3 more
europepmc   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Early in-hospital initiation of angiotensin-receptor-neprilysin inhibitor in post-acute myocardial infarction patients with impaired left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Cardiovasc Med
Nguyen Q, Tran TTQ, Liao CT, Hung CL, Chang HY, Chen CW, Lin YC, Huang CY, Hsu CY.   +8 more
europepmc   +1 more source

Newly Developed Mimetic Peptides for Angiotensin II Type 1 Receptor Attenuate Doxorubicin-Induced c-Jun N-Terminal Kinase Activation, a Marker of Pro-Apoptotic Stress Signaling. [PDF]

Biomedicines
Matsuo Y, Suematsu Y, Miura SI.
europepmc   +1 more source

Zilebesiran, a Small Interfering RNA Therapeutic Targeting Angiotensinogen: Mechanism, Clinical Evidence, Safety, and Implementation Considerations. [PDF]

Life (Basel)
Jawaria, Noor A, Zarlashat Y, Khan MEA, Loureiro EM, Dósa E.   +5 more
europepmc   +1 more source