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Angiotensin type-1 receptor blockers in heart failure
Progress in Cardiovascular Diseases, 2002Chronic heart failure is a common condition with a poor prognosis, usually associated with poor exercise tolerance and debilitating symptoms despite optimal modern therapy. Standard therapy includes diuretics, digoxin, angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers.
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Valsartan: a novel angiotensin Type 1 receptor antagonist
Expert Opinion on Pharmacotherapy, 2000Valsartan is a highly selective, orally available antagonist of the angiotensin Type 1 (AT1) receptor. It is indicated for treatment of mild to moderate essential hypertension. Experimental studies have confirmed the abolition or attenuation of angiotensin II (AII)-related effects, such as vasoconstriction, cell growth promotion and aldosterone release.
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Regulation of Vascular Type 1 Angiotensin Receptors by Cytokines
Hypertension, 1997AbstractAlthough various cytokines are known to be expressed in atherosclerotic lesions, it is not known how these cytokines affect receptors for the peptide hormone angiotensin II (Ang II). We therefore examined the effects of interleukin-1α (220 U/mL [10 ng/mL]), tumor necrosis factor-α (280 U/mL [100 ng/mL]), and interferon gamma (100 U/mL) on Ang ...
H, Sasamura +5 more
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[Angiotensin-2 type 1 receptors (AT1R) and cancers].
Nephrologie & therapeutique, 2013Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to ...
Dolley-Hitze, Thibault +8 more
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Biased Agonism of the Angiotensin II Type 1 Receptor
Mini-Reviews in Medicinal Chemistry, 2012G protein-coupled receptors (GPCRs) can be activated by multiple ligands and exhibit the capacity to couple to numerous intracellular signal transduction pathways. This property allows GPCRs to be modulated by biased agonists that selectively activate specific subsets of GPCR-regulated cellular signaling proteins.
C M, Godin, S S G, Ferguson
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[Angiotensin II type 1 and type 2 receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2009The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
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Endocytosis and signaling of angiotensin II type 1 receptor
2023A vasoactive octapeptide angiotensin II (Ang II) hormone is the key regulator of the renin-angiotensin system (RAS). It binds with the two different plasma membrane receptors like angiotensin II type 1 (AT1) and type 2 (AT2) and consequence various biological responses occur. Further, AT1 has two subtypes such as AT1A and AT1B.
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The Angiotensin II Type 1 Receptor Antagonists
Archives of Internal Medicine, 1995The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace All from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release.
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Angiotensin II type 1 receptor antagonists
Biochemical Pharmacology, 2000Patrick M.L Vanderheyden +2 more
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