Results 271 to 280 of about 181,641 (286)
Some of the next articles are maybe not open access.
The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems
Molecular Medicine Today, 1995Since its discovery, the functions of the renin-angiotensin system (RAS) have attracted a great deal of attention, and the roles it plays under normal conditions, and in disease, acquire a deepening significance with every year. In general, the RAS has been considered largely in terms of its roles in sodium and potassium homeostasis and the regulation ...
G P, Vinson, M M, Ho, J R, Puddefoot
openaire +2 more sources
Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy
Hypertension, 1996We compared the ability of angiotensin II (Ang II) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. Over 72 hours, Ang II (1 μmol/L) increased the ratio of protein to DNA by less than 10%, whereas endothelin-1 (100 nmol/L) produced a 28% increase.
G W, Booz, K M, Baker
openaire +2 more sources
Valsartan: a novel angiotensin Type 1 receptor antagonist
Expert Opinion on Pharmacotherapy, 2000Valsartan is a highly selective, orally available antagonist of the angiotensin Type 1 (AT1) receptor. It is indicated for treatment of mild to moderate essential hypertension. Experimental studies have confirmed the abolition or attenuation of angiotensin II (AII)-related effects, such as vasoconstriction, cell growth promotion and aldosterone release.
openaire +2 more sources
[Angiotensin-2 type 1 receptors (AT1R) and cancers].
Nephrologie & therapeutique, 2013Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to ...
Dolley-Hitze, Thibault +8 more
openaire +2 more sources
Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors
Current Pharmaceutical Design, 2013Renin-angiotensin system (RAS) plays a key role in pathogenesis of cardiovascular disease and in the responsiveness for various types of medications. A large number of genetic investigations have been carried out to examine the association between gene variants of RAS and predisposition to cardiovascular diseases, such as hypertension, coronary artery ...
Tomohiro, Katsuya, Ryuichi, Morishita
openaire +2 more sources
[Angiotensin II type 1 and type 2 receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2009The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
openaire +1 more source
The Angiotensin II Type 1 Receptor Antagonists
Archives of Internal Medicine, 1995The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace All from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release.
openaire +1 more source