Results 61 to 70 of about 181,641 (286)

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Jean Irving, Paul E Stevens, Irving, Jean, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +7 more
core   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy

The Scientific World Journal, 2008
Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
doaj   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Michelson, G., Hilgers, K.F., Oehmer, S., Harazny, J., Delles, C., Schmieder, R.E.   +5 more
core   +1 more source

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells [PDF]

, 2021
Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Saravi, Babak E., Li, Zhen, Wystrach, Laura, Lang, Gernot, Robert Geoffrey Richards, Albers, Christoph E., Mauro Alini, Albers, Christoph E, Häckel, Sonja, Zhen Li, Wystrach, Laura Wanda, Saravi, Babak, Babak Saravi, Pfannkuche, Judith, Lang, Corinna N., Schmal, Hagen, Norbert Südkamp, Sonja Häckel, Laura Wystrach, Judith Pfannkuche, Alini, Mauro, Gernot Lang, Südkamp, Norbert, Richards, Robert Geoffrey, Sibylle Grad, Christoph E. Albers, Lang, Corinna, Hagen Schmal, Grad, Sibylle, Corinna Lang, Pfannkuche, Judith-J.   +30 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Angiotensin II type 1 receptor antagonists and their combinations in the treatment of hypertension

South African Family Practice, 2012
No abstract available.
J.A. Ker
doaj   +1 more source

The Angiotensin II Type 1 Receptor-Associated Protein Attenuates Angiotensin II-Mediated Inhibition of the Renal Outer Medullary Potassium Channel in Collecting Duct Cells

Frontiers in Physiology, 2021
Adjustments in renal K+ excretion constitute a central mechanism for K+ homeostasis. The renal outer medullary potassium (ROMK) channel accounts for the major K+ secretory route in collecting ducts during basal conditions.
Juliano Zequini Polidoro, Nancy Amaral Rebouças, Adriana Castello Costa Girardi   +2 more
doaj   +1 more source

Expression of angiotensin II type 1 receptor in rat bladder smooth muscle cells in response to a streptzotocin induced diabetes mellitus model [PDF]

, 2012
Introduction: The aim of this study was to investigate angiotensin II type 1 (AT1) receptors in rat bladder smooth muscle cells and alterations of AT1 receptors by diabetes mellitus and diuretic states.
Tobu, Shohei, Matsuo, Manabu, Mori, Ken-ichi, Sakai, Hideki, Hatada, Teppei, Noguchi, Mitsuru   +5 more
core   +1 more source