Results 131 to 140 of about 174,002 (143)

Is the angiotensin ii type 2 receptor cerebroprotective?

Current Hypertension Reports, 2004
Most of the deleterious effects of angiotensin II (Ang II) on blood pressure (BP), cardiovascular remodeling, and atherosclerosis are mediated by Ang II type 1 (AT1)-receptor activation. This explains why Ang-II-decreasing or blocking drugs have been successful in decreasing global cardiovascular morbimortality in patients with cardiac complications ...
Fournier, A., Achard, J.M., Boutitie, Florent, Mazouz, H., Mansour, J., Oprisiu, R., Fernandez, L., Messerli, F.   +7 more
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Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

Clinical Science, 2014
The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin–angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists
Villela, Daniel, Leonhardt, Julia, Patel, Neal, Joseph, Jason, Kirsch, Sebastian, Hallberg, Anders, Unger, Thomas, Bader, Michael, Santos, Robson A, Sumners, Colin, Steckelings, Ulrike Muscha   +10 more
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Angiotensin type-2 receptors and cardiovascular function: are angiotensin type-2 receptors protective?

Current Opinion in Cardiology, 2005
The renin-angiotensin system is a coordinated hormonal cascade of critical importance to the regulation of blood pressure and cardiovascular function. The major effector peptide, angiotensin II, binds to two major receptors, angiotensin type-1 and angiotensin type-2. Most of the actions of angiotensin II are mediated by the angiotensin type-1 receptor,
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Heterogeneity of Angiotensin Type 2 (AT2) Receptors

1996
Evidence continues to accumulate that strengthens the proposal of heterogeneity within both the AT1 and the AT2 receptor subtypes. Pharmacologic, biochemical and immunological studies of AT2 receptors expressed in N1E-115 cells strengthen the hypothesis of AT2 receptor heterogeneity.
L P, Reagan, D K, Yee, P F, He, S J, Fluharty   +3 more
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Angiotensin type 2 receptor in hypertensive cardiovascular disease

Current Opinion in Nephrology & Hypertension, 2011
The renin angiotensin system plays a key role in the development of hypertension-induced cardiovascular remodeling and cardiovascular damage. Angiotensin II (Ang II) exerts its effects by acting on two distinct subtypes of receptor, the angiotensin type 1 receptor (AT1R) and the angiotensin type 2 receptor (AT2R).
SAVOIA, Carmine, M. D'Agostino, Francesco Lauri, VOLPE, Massimo   +3 more
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Functional Aspects of Angiotensin Type 2 Receptor

1996
Angiotensin II (AngII) exerts various actions in its diverse target tissues controlling vascular tone, hormone secretion, tissue growth, and neuronal activities. Extensive pharmacological evidence indicates that most of the known effects of AngII in adult tissues are mediated by the seven-transmembrane G-protein coupled Angll type 1 (AT1) receptor ...
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Vascular angiotensin II actions mediated by angiotensin II type 2 receptors

Current Hypertension Reports, 2004
Angiotensin II (Ang II) is the major effector peptide of the renin-angiotensin system and acts at two major receptors known as Ang II type 1 receptor (AT(1)R) and Ang II type 2 receptor (AT(2)R). Increasingly, there is evidence suggesting that the AT(2)R counter-regulates the excitatory effects of AT(1)R stimulation.
Ruth E, Hannan, Robert E, Widdop
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Angiotensin Type 2 Receptor (AT2R): A Challenging Twin

Science Signaling, 2003
Angiotensin II (AngII) regulates such physiological responses as salt and water balance, blood pressure, and vascular tone, and thus plays a critical role in the pathogenesis of diabetes, hypertension, myocardial infarction, congestive heart failure, and stroke.
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Stimulation of ANP by angiotensin-(1-9) via the angiotensin type 2 receptor

Life Sciences, 2013
Angiotensin-(1-9) [Ang-(1-9)] and Ang-(1-7) are cleaved by Ang converting enzyme 2 forming Ang I and Ang II, respectively, and the truncated Angs play a role in regulating atrial natriuretic peptide (ANP) secretion. Previously, we found that Ang-(1-7) stimulates ANP secretion via the Mas receptor.
Seung Ah, Cha, Byung Mun, Park, Shan, Gao, Suhn Hee, Kim   +3 more
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Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy

Hypertension, 1996
We compared the ability of angiotensin II (Ang II) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. Over 72 hours, Ang II (1 μmol/L) increased the ratio of protein to DNA by less than 10%, whereas endothelin-1 (100 nmol/L) produced a 28% increase.
G W, Booz, K M, Baker
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