Results 251 to 260 of about 270,851 (310)

Attenuation of arsenic trioxide‐induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging

VIEW, EarlyView.
Inhibiting the SUMOylation modification of TRPM4 can prevent the vascular endothelial damage caused by ATO. Inhibition of TRPM4 SUMOylation, either pharmacologically by GA or genetically by the K618R mutation, protects against ATO‐induced vascular endothelial damage.
Ting‐Ting Tong, Ya‐Dong Xue, Yu‐Yao Zhang, Chun‐Xiao Yu, Xin‐Yu Yao, Yu‐Xuan Han, Kai Zhang, Mei‐Mei Shen, Yu Zhao, Yun‐Feng Cui, Zi‐Yue Ma, Yu‐Yang Fu, Yong‐Zhen Wang, Jing Jin, Ke Tang, Yang Liu, Yang Li, Rong Huo, Tao Ban   +18 more
wiley   +1 more source

Association Between Insulin Therapy and In-Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume. [PDF]

J Diabetes
Luo X, Zhang L, Feng B, Ou X, Lin J, Zhuo D, Gao H, Liu L, Xu M, Liu J, Jia F, Fan G.   +11 more
europepmc   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Pediatric Heart Failure Pharmacotherapy: Transformative Insights for the Future. [PDF]

Rev Cardiovasc Med
Das BB.
europepmc   +1 more source

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews, Arron Lacey, Kate Bache, Emma J. Kidd   +3 more
wiley   +1 more source

B-type natriuretic peptide changes and left ventricular remodeling dynamics in heart failure with reduced ejection fraction. [PDF]

Front Cardiovasc Med
Romero E, Kushnir Y, Shahzad A, Patel DJ, Heejung B, Sirish P, Chiamvimonvat N, Liem DA, Cadeiras M.   +8 more
europepmc   +1 more source

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High‐Altitude Adaptive Genetic Variants in Sherpa Highlanders

Annals of Human Genetics, EarlyView.
ABSTRACT Background and Aims Sherpa highlanders exhibit remarkable tolerance to hypoxia, most likely due to genetic adaptations shaped by natural selection at high altitude. This study examined the roles of endothelial PAS domain protein 1 (EPAS1) and egl‐9 family hypoxia‐inducible factor 1 (EGLN1) in the genetic mechanisms underlying this adaptation ...
Yunden Droma, Fengming Yue, Masao Ota, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki Hanaoka   +5 more
wiley   +1 more source

Exploring the Interplay Between Hypertension and Osteoporosis: A Narrative Review. [PDF]

Cureus
Gutierrez Y, Shaju RA, Sepulveda A, Coban S.   +3 more
europepmc   +1 more source

Managing Skin Side Effects Associated With Oncology Treatments: Asian Perspective on Use of Dermocosmetics

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Skin adverse events (AEs) frequently accompany all types of anticancer treatments. This publication discusses how recent international guidance on best‐practices use of dermocosmetics can be adapted to the North Asia region (China, Hong Kong, Japan, Republic of Korea, and Taiwan).
Meng Pan, Jianguo Sun, Makoto Kawashima, You Chan Kim, Mison Chun, Chia‐Yu Chu, Yi‐Hsin Liang, Mee Chang, Delphine Kerob, Brigitte Dreno   +9 more
wiley   +1 more source

Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. [PDF]

Eur J Heart Fail
Porcari A, Milani P, Longhi S, Cappelli F, Vagnarelli F, Aimo A, Cipriani A, Gardini E, Marazia S, Monda E, Tini G, Musumeci B, Serenelli M, Cantone A, Lofiego C, Marini M, Vergaro G, Foti G, Musca F, Tomasoni D, Bonacchi G, Colio F, Sinigiani G, De Michieli L, Sturdà F, Pozzan M, Gentile P, Carigi S, Bartolotti M, Sena G, Ruotolo I, Sanna GD, Zanoletti M, Canepa M, Di Marco M, D'Elia E, Di Bella G, Driussi M, Imazio M, Perfetto F, Biagini E, Limongelli G, Metra M, Emdin M, Merlini G, Perlini S, Merlo M, Palladini G, Sinagra G.   +48 more
europepmc   +1 more source