Results 271 to 280 of about 270,851 (310)

Heterogeneity of Angiotensin Type 2 (AT2) Receptors

1996
Evidence continues to accumulate that strengthens the proposal of heterogeneity within both the AT1 and the AT2 receptor subtypes. Pharmacologic, biochemical and immunological studies of AT2 receptors expressed in N1E-115 cells strengthen the hypothesis of AT2 receptor heterogeneity.
L P, Reagan, D K, Yee, P F, He, S J, Fluharty   +3 more
openaire   +2 more sources

Angiotensin type 2 receptor in hypertensive cardiovascular disease

Current Opinion in Nephrology & Hypertension, 2011
The renin angiotensin system plays a key role in the development of hypertension-induced cardiovascular remodeling and cardiovascular damage. Angiotensin II (Ang II) exerts its effects by acting on two distinct subtypes of receptor, the angiotensin type 1 receptor (AT1R) and the angiotensin type 2 receptor (AT2R).
SAVOIA, Carmine, M. D'Agostino, Francesco Lauri, VOLPE, Massimo   +3 more
openaire   +3 more sources

Protecting glomerulus: role of angiotensin-II type 2 receptor

Clinical Science, 2022
Abstract Podocyte injury due to either drug, toxin, infection, or metabolic abnormality is a great concern as it increases the risk of developing focal segmental glomerulosclerosis (FSGS) and proteinuric kidney diseases. The direct podocyte injury due to doxorubicin is associated with an increase in proinflammatory cytokines and ...
Sanket Patel, Kalyani Kulkarni, Tahir Hussain   +2 more
openaire   +2 more sources

Is the angiotensin ii type 2 receptor cerebroprotective?

Current Hypertension Reports, 2004
Most of the deleterious effects of angiotensin II (Ang II) on blood pressure (BP), cardiovascular remodeling, and atherosclerosis are mediated by Ang II type 1 (AT1)-receptor activation. This explains why Ang-II-decreasing or blocking drugs have been successful in decreasing global cardiovascular morbimortality in patients with cardiac complications ...
Fournier, A., Achard, J.M., Boutitie, Florent, Mazouz, H., Mansour, J., Oprisiu, R., Fernandez, L., Messerli, F.   +7 more
openaire   +3 more sources

The angiotensin type 2 receptor and the kidney

Current Opinion in Nephrology and Hypertension, 2017
Angiotensin II is a main regulator of kidney function. Renal actions mediated by the angiotensin AT1 receptor have been well known for many years. In contrast, several details of angiotensin AT2 receptor actions in kidney physiology and pathophysiology were only described very recently.
Peluso, A.A.B., Santos, R.A.S., Unger, T., Steckelings, U.M.   +3 more
openaire   +4 more sources

Vascular angiotensin II actions mediated by angiotensin II type 2 receptors

Current Hypertension Reports, 2004
Angiotensin II (Ang II) is the major effector peptide of the renin-angiotensin system and acts at two major receptors known as Ang II type 1 receptor (AT(1)R) and Ang II type 2 receptor (AT(2)R). Increasingly, there is evidence suggesting that the AT(2)R counter-regulates the excitatory effects of AT(1)R stimulation.
Ruth E, Hannan, Robert E, Widdop
openaire   +2 more sources

Angiotensin 2 type 2 receptor activity and ischemic stroke severity

Neurology, 2005
Drugs that increase angiotensin 2 formation, including thiazides, calcium channel blockers, and angiotensin 2 type 1 (AT1) receptor blockers, may be more effective in stroke prevention than angiotensin 2 suppressive drugs such as angiotensin-converting enzyme inhibitors and beta-blockers.To assess whether angiotensin 2 formation increasing drugs reduce
B, Ovbiagele, C S, Kidwell, S, Starkman, S L, Selco, V, Rajajee, T, Razinia, J L, Saver   +6 more
openaire   +2 more sources

Angiotensin Type 2 Receptor (AT2R): A Challenging Twin

Science Signaling, 2003
Angiotensin II (AngII) regulates such physiological responses as salt and water balance, blood pressure, and vascular tone, and thus plays a critical role in the pathogenesis of diabetes, hypertension, myocardial infarction, congestive heart failure, and stroke.
openaire   +2 more sources

Functional Aspects of Angiotensin Type 2 Receptor

1996
Angiotensin II (AngII) exerts various actions in its diverse target tissues controlling vascular tone, hormone secretion, tissue growth, and neuronal activities. Extensive pharmacological evidence indicates that most of the known effects of AngII in adult tissues are mediated by the seven-transmembrane G-protein coupled Angll type 1 (AT1) receptor ...
openaire   +2 more sources

[Angiotensin-2 type 1 receptors (AT1R) and cancers].

Nephrologie & therapeutique, 2013
Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to ...
Dolley-Hitze, Thibault, Verhoest, Grégory, Jouan, Florence, Le Pogamp, Patrick, Arlot-Bonnemains, Yannick, Oger, Emmanuel, Belaud-Rotureau, Marc-Antoine, Rioux-Leclercq, Nathalie, Vigneau, Cécile   +8 more
openaire   +2 more sources