Results 131 to 140 of about 5,853 (186)

Activation of B2 bradykinin receptors by neurotensin

Cellular Signalling, 2003
Many previous reports suggested that relatively high concentrations of neurotensin were required to exert its effects on neurotransmitter secretion. The neurotensin binding sites, which recognize high concentrations of neurotensin, were characterized in rat pheochromocytoma (PC12) cells. When PC12 cells were treated with neurotensin, [3H]norepinephrine
Park, TJ, Kim, KT
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Intracellular and nuclear bradykinin B2 receptors

European Journal of Pharmacology, 2014
Bradykinin is a vasoactive peptide that participates in numerous inflammatory processes, vasodilation, and cell growth/survival; it mainly acts through two receptor subtypes, bradykinin B1 and bradykinin B2 receptors, which are G protein-coupled receptor (GPCR) family members.
Masaoki Takano, Shogo Matsuyama
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New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization

Trends in Pharmacological Sciences, 1990
Substantial progress has been made recently in the field of kinin pharmacology with the identification of sensitive bioassay organs and the discovery of bradykinin B2 receptor antagonists. Data obtained with such compounds in various laboratories support the hypothesis that kinins act on multiple (at least two) receptor types.
D, Regoli, N E, Rhaleb, S, Dion, G, Drapeau   +3 more
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Theoretical Study of the Human Bradykinin–Bradykinin B2 Receptor Complex

ChemBioChem, 2008
AbstractThe interaction of bradykinin (BK) with the bradykinin B2 receptor (B2R) was analyzed by using molecular modeling (MM) and molecular dynamics (MD) simulations. A homology model for B2R has been generated and the recently determined receptor‐bound solid‐state NMR spectroscopic structure of BK (Lopez et al., Angew. Chem.
Artur Giełdoń, Jakob J. Lopez, Clemens Glaubitz, Harald Schwalbe   +3 more
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Intramolecular signal transduction by the bradykinin B2 receptor

International Immunopharmacology, 2002
To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved tripeptide sequence Asp-Arg-Tyr ...
Sylvia, Mueller, Claus, Liebmann, Siegmund, Reissmann   +2 more
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Targeting the ‘Janus face' of the B2-bradykinin receptor

Expert Opinion on Therapeutic Targets, 2013
Kinins are main active mediators of the kallikrein-kinin system (KKS) via bradykinin type 1 inducible (B1R) and type 2 constitutive (B2R) receptors. B2R mediates most physiological bradykinin (BK) responses, including vasodilation, natriuresis, NO, prostaglandins release.The article summarizes knowledge on kinins, B2R signaling and biological functions;
Nelly, Blaes, Jean-Pierre, Girolami
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Localization of bradykinin B2 receptors in sheep uterus

Immunopharmacology, 1996
The localization and characterization of bradykinin B2 receptors in sheep uterus was carried out using a radiolabelled B2 receptor ligand, 3,4-hydroxyphenypropionyl-D-Arg0-[Hyp3,Thi5,D-++ +Tic7,D-Oic8] bradykinin (HPP-HOE140). Competition of the radioligand, [125I]HPP-HOE140, from membrane preparations of anoestrus sheep uterus by bradykinin agonists ...
C, Murone, R B, Perich, I, Schlawe, W, Müller-Esterl, F A, Mendelsohn, S Y, Chai   +5 more
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B2 bradykinin receptor immunoreactivity in rat brain

The Journal of Comparative Neurology, 2000
Bradykinin has long been known to exist in the central nervous system and has been hypothesized to mediate specific functions. Despite an increasing understanding of the functions of bradykinin, little is known about the cell types expressing the bradykinin receptor within the brain.
E Y, Chen, D F, Emerich, R T, Bartus, J H, Kordower   +3 more
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Structural characterization of lipopeptide agonists for the bradykinin B2 receptor

Biopolymers, 2001
The conformational features of Pam-Lys(0)-Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)-OH (PKD) and Pam-Gly(-1)-Lys(0)-Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)-OH (PGKD), the Pam-Lys and Pam-Gly-Lys analogues of bradykinin, have been determined by high-resolution NMR in a zwitterionic lipoid environment.
GIRAGOSSIAN C., NARDI E., SAVERY C., PELLEGRINI M., MEINI S., MAGGI C. A., PAPINI, ANNA MARIA, MIERKE D.   +7 more
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Nonpeptide Mimic of Bradykinin with Long-Acting Properties at the Bradykinin B2 Receptor

Molecular Pharmacology, 1997
Kinins, members of a family of peptides released from kininogens by the action of kallikreins, exhibit a variety of biological activities including vasodilation, increased vascular permeability, contraction of smooth muscle cells, and activation of sensory neurons.
I, Aramori, J, Zenkoh, N, Morikawa, M, Asano, C, Hatori, H, Sawai, H, Kayakiri, S, Satoh, T, Inoue, Y, Abe, Y, Sawada, T, Mizutani, N, Inamura, K, Nakahara, H, Kojo, T, Oku, Y, Notsu   +16 more
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