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Cloning of a B2 Bradykinin Receptor: Examination of the Bradykinin Binding Site by Site Directed Mutagenesis

1992
A cDNA encoding a bradykinin receptor has been isolated. In oocytes expressing the receptor, bradykinin-induced chloride current is blocked by [Thi5,8 dPhe7]BK and is unaffected by des-Arg9-BK suggesting that the cDNA encodes a classical B2 type receptor. The predicted protein sequence is homologous to other G protein-coupled receptors.
R, Freedman, K, Jarnagin
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Simulations on the activation of the bradykinin B2 receptor

Biochemical Society Transactions, 1996
S W, Doughty, C A, Reynolds
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Bradykinin B2 Receptor Antagonists for the Treatment of Pain

2004
Publisher Summary The bradykinin B2 receptor is a mature G-protein coupled receptor target that has long offered the prospect of therapeutic intervention in pain and inflammation, but this has been notoriously difficult to achieve. This chapter discusses the kinin B2 receptor as a therapeutic target, peptide bradykinin B2 receptor antagonists, and ...
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Multiple bradykinin B2 receptors

Trends in Pharmacological Sciences, 1989
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Search for autoantibodies to the human bradykinin B2 receptor

Immunopharmacology, 1997
P, Micke, A, Blaukat, W, Müller-Esterl
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Association of solubilized bradykinin B2 receptors with G-proteins

Biochemical Society Transactions, 1993
M, Yaqoob   +3 more
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Visualisation of bradykinin B2 receptors on human brain neurons

Immunopharmacology, 1996
D M, Raidoo   +5 more
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Bradykinin B2 receptor as a potential therapeutic target.

Drug news & perspectives, 2003
Kinins are peptide hormones that exert pathophysiological as well as pronounced beneficial physiological effects, mainly by stimulation of bradykinin (BK) B(2) receptors. Owing to the strong proinflammatory properties of kinins resulting from vasodilation, plasma extravasation, activation of mast cells, fibroblasts and macrophages, stimulation of ...
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