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1992
A cDNA encoding a bradykinin receptor has been isolated. In oocytes expressing the receptor, bradykinin-induced chloride current is blocked by [Thi5,8 dPhe7]BK and is unaffected by des-Arg9-BK suggesting that the cDNA encodes a classical B2 type receptor. The predicted protein sequence is homologous to other G protein-coupled receptors.
R, Freedman, K, Jarnagin
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A cDNA encoding a bradykinin receptor has been isolated. In oocytes expressing the receptor, bradykinin-induced chloride current is blocked by [Thi5,8 dPhe7]BK and is unaffected by des-Arg9-BK suggesting that the cDNA encodes a classical B2 type receptor. The predicted protein sequence is homologous to other G protein-coupled receptors.
R, Freedman, K, Jarnagin
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Simulations on the activation of the bradykinin B2 receptor
Biochemical Society Transactions, 1996S W, Doughty, C A, Reynolds
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Bradykinin B2 Receptor Antagonists for the Treatment of Pain
2004Publisher Summary The bradykinin B2 receptor is a mature G-protein coupled receptor target that has long offered the prospect of therapeutic intervention in pain and inflammation, but this has been notoriously difficult to achieve. This chapter discusses the kinin B2 receptor as a therapeutic target, peptide bradykinin B2 receptor antagonists, and ...
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Search for autoantibodies to the human bradykinin B2 receptor
Immunopharmacology, 1997P, Micke, A, Blaukat, W, Müller-Esterl
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Association of solubilized bradykinin B2 receptors with G-proteins
Biochemical Society Transactions, 1993M, Yaqoob +3 more
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Visualisation of bradykinin B2 receptors on human brain neurons
Immunopharmacology, 1996D M, Raidoo +5 more
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Bradykinin B2 receptor as a potential therapeutic target.
Drug news & perspectives, 2003Kinins are peptide hormones that exert pathophysiological as well as pronounced beneficial physiological effects, mainly by stimulation of bradykinin (BK) B(2) receptors. Owing to the strong proinflammatory properties of kinins resulting from vasodilation, plasma extravasation, activation of mast cells, fibroblasts and macrophages, stimulation of ...
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