Results 141 to 150 of about 17,282 (158)

Cannabinoid Receptor 1 (CB1)

2021
CB1 receptors mediate most central nervous system effects ascribed to the phytocannabinoid Δ-9-tetrahydrocannabinol (THC). CB1 receptors are guanine nucleotide-binding regulatory protein-coupled receptors that primarily activate Gi/o proteins, resulting in the inhibition of adenylyl cyclase.
Glenn R. Rech, Samer N. Narouze
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CB1 cannabinoid receptor-mediated aggressive behavior

Neuropharmacology, 2013
This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT).
Rodríguez-Arias, Marta, Navarrete, Francisco, Daza-Losada, Manuel, Navarro, Daniela, Aguilar, María A., Berbel, Pere, Miñarro, José, Manzanares, Jorge   +7 more
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CB1 Cannabinoid Receptor-Mediated Cell Migration

The Journal of Pharmacology and Experimental Therapeutics, 2000
Recent studies have suggested that cell migratory responses are often mediated by G(i) protein-coupled receptors. Because it is known that CB1 cannabinoid receptors are coupled to pertussis toxin-sensitive G proteins, we proposed that CB1 may mediate cell migration.
Z H, Song, M, Zhong
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Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons

The Journal of Pharmacology and Experimental Therapeutics, 2007
Migraine is a common and disabling neurological disorder that involves activation or the perception of activation of the trigeminovascular system. Cannabinoid (CB) receptors are present in brain and have been suggested to be antinociceptive. Here we determined the effect of cannabinoid receptor activation on neurons with trigeminovascular nociceptive ...
Akerman, Simon, Holland, Philip R, Goadsby, Peter J   +2 more
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Multiple mechanisms of CB1 cannabinoid receptors regulation

Brain Research, 2003
Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors. In HEK-293 cells, CB1 receptors internalization proceeded, in parallel, via clathrin-coated pits and caveolae.
Ora, Keren, Yosef, Sarne
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Cannabinoid CB1 receptors control conditioned drug seeking

Trends in Pharmacological Sciences, 2005
Recent developments have implicated cannabinoid CB1 receptors as a novel target for a new class of therapeutic agents used to treat drug addiction. CB1 receptors are expressed in the motivational circuitry of the brain and modulate drug seeking. Blockade of the CB1 receptor is particularly effective in reducing cue-induced reinstatement of drug seeking,
De Vries, Taco J, Schoffelmeer, Anton N M   +1 more
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Allosteric Modulation of the Cannabinoid CB1 Receptor

Molecular Pharmacology, 2005
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2 ...
Martin R, Price, Gemma L, Baillie, Adèle, Thomas, Lesley A, Stevenson, Morag, Easson, Richard, Goodwin, Adèle, McLean, Lorraine, McIntosh, Gillian, Goodwin, Glenn, Walker, Paul, Westwood, Julia, Marrs, Fiona, Thomson, Phillip, Cowley, Arthur, Christopoulos, Roger G, Pertwee, Ruth A, Ross   +16 more
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Pentacycle derivatives as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB-1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of pentacycle derivatives.
Suk Ho, Lee, Hee Jeong, Seo, Min Ju, Kim, Suk Youn, Kang, Sung-Han, Lee, Kwangwoo, Ahn, Minwoo, Lee, Ho-Kyun, Han, Jeongmin, Kim, Jinhwa, Lee   +9 more
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Substituted pyrimidines as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB1 receptors have been the avenue of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of substituted pyrimidines based ...
Min Ju, Kim, Jong Yup, Kim, Hee Jeong, Seo, Junwon, Lee, Sung-Han, Lee, Mi-Soon, Kim, Jahyo, Kang, Jeongmin, Kim, Jinhwa, Lee   +8 more
openaire   +2 more sources

CB1 cannabinoid receptor induction in experimental stroke

Annals of Neurology, 2000
Cannabinoids protect cortical neurons from ischemic injury by interacting with CB1 receptors. Because a variety of neuroprotective genes are induced in cerebral ischemia, we examined the effect of experimental stroke, produced by 20 minutes of middle cerebral artery occlusion in rats, on CB1 receptor expression.
K L, Jin, X O, Mao, P C, Goldsmith, D A, Greenberg   +3 more
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